Continuous infusion of beta-lactam antibiotics

Correlation of Antimicrobial Pharmacokinetic Parameters with Therapeutic Efficacy in an Animal Model

1988 • 714 citations

Observations on the Mechanism of Action of Penicillin.

1942 • 420 citations

Comparative Antibiotic Dose-Effect Relations at Several Dosing Intervals in Murine Pneumonitis and Thigh-Infection Models

1989 • 352 citations

Kinetics of antimicrobial activity

1986 • 320 citations

Postantibiotic Suppression of Bacterial Growth

1981 • 311 citations

Killing and regrowth of bacteria in vitro: a review.

1990 • 301 citations

In Vivo Postantibiotic Effect in a Thigh Infection in Neutropenic Mice

1988 • 273 citations

Continuous vs. Discontinuous Therapy with Penicillin

1953 • 232 citations

A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients

1979 • 210 citations

Effect of schedule of administration on the therapeutic efficacy of penicillin

1950 • 199 citations

Persistent Effect of Antibiotics on Staphylococcus aureus after Exposure for Limited Periods of Time

1977 • 197 citations

Postantibiotic Leukocyte Enhancement: Increased Susceptibility of Bacteria Pretreated with Antibiotics to Activity of Leukocytes

1981 • 187 citations

Evaluation of the bactericidal activity of beta-lactam antibiotics on slowly growing bacteria cultured in the chemostat

1986 • 177 citations

Postantibiotic effect of imipenem on Pseudomonas aeruginosa

1984 • 145 citations

Comparative dose-effect relations at several dosing intervals for beta-lactam, aminoglycoside and quinolone antibiotics against gram-negative bacilli in murine thigh-infection and pneumonitis models.

1990 • 135 citations

THE BACTERICIDAL ACTION OF PENICILLIN IN VIVO: THE PARTICIPATION OF THE HOST, AND THE SLOW RECOVERY OF THE SURVIVING ORGANISMS

1950 • 123 citations

THE SLOW RECOVERY OF BACTERIA FROM THE TOXIC EFFECTS OF PENICILLIN

1949 • 120 citations

THE EFFECTIVE CONCENTRATIONS OF PENICILLIN IN VITRO AND IN VIVO FOR STREPTOCOCCI, PNEUMOCOCCI, AND TREPONEMA PALLIDUM

1950 • 112 citations

Continuous-infusion ampicillin therapy of enterococcal endocarditis in rats

1987 • 108 citations

Antibacterial Activity of -Lactam Antibiotics in Experimental Meningitis Due to Streptococcus pneumoniae

1984 • 106 citations

Continuous versus intermittent administration of ceftazidime in experimental Klebsiella pneumoniae pneumonia in normal and leukopenic rats

1986 • 100 citations

Therapeutic Efficacy of Continuous Versus Intermittent Administration of Ceftazidime in an Experimental Klebsiella pneumoniae Pneumonia in Rats

1985 • 99 citations

Penetration of Antibiotics into Fibrin Loci in Vivo. III. Intermittent vs. Continuous Infusion and the Effect of Probenecid

1974 • 93 citations

Pharmacokinetics of ceftazidime in serum and suction blister fluid during continuous and intermittent infusions in healthy volunteers

1990 • 90 citations

The in-vivo postantibiotic effect of imipenem and other new antimicrobials

1986 • 85 citations

The Postantibiotic Effect in the Treatment of Experimental Meningitis Caused by Streptococcus pneumoniae in Rabbits

1984 • 83 citations

Intermittent or Continuous Therapy of Experimental Meningitis Due to Streptococcus pneumoniae in Rabbits: Preliminary Observations on the Postantibiotic Effect in Vivo

1981 • 79 citations

Penicillin Resistance and Defective Lysis in Clinical Isolates of Pneumococci: Evidence for Two Kinds of Antibiotic Pressure Operating in the Clinical Environment

1988 • 74 citations

The Action of Penicillin onStaphylococcus:Further Observations on the Effect of a Short Exposure

1948 • 71 citations

Integration of pharmacokinetics and pharmacodynamics of imipenem in a human-adapted mouse model

1991 • 65 citations

BACTERIOSTATIC AND LYTIC ACTIONS OF PENICILLIN ON SENSITIVE AND RESISTANT STAPHYLOCOCCI 1

1945 • 65 citations

Efficacy of continuous versus intermittent administration of penicillin G inStreptococcus pneumoniae pneumonia in normal and immunodeficient rats

1984 • 60 citations

Bactericidal Activity of Cephalosporins in an In Vitro Model Simulating Serum Levels

1978 • 59 citations

EFFECT OF STORAGE OF PENICILLIN-G SOLUTIONS ON SENSITISATION TO PENICILLIN-G AFTER INTRAVENOUS ADMINISTRATION

1982 • 56 citations

Postantibiotic effect of beta-lactam antibiotics on Escherichia coli evaluated by bioluminescence assay of bacterial ATP

1990 • 56 citations

Postantibiotic effect of penicillin plus gentamicin versus Enterococcus faecalis in vitro and in vivo

1989 • 54 citations

Neutropenia after penicillins: Toxic or immune-mediated?

1981 • 52 citations

Treatment of gram-negative bacillary septicemia with cefoperazone

1983 • 50 citations

Absence of a Postantibiotic Effect in Experimental Pseudomonas Endocarditis Treated With Imipenem, With or Without Gentamicin

1988 • 49 citations

Adverse reactions following intravenous penicillin-G relate to degradation of the drug in vitro

1984 • 48 citations

Combination antibiotic therapy: comparison of constant infusion and intermittent bolus dosing in an experimental animal model

1985 • 47 citations

Dosis-Wirkungs-Beziehung der Bakterizidie bei E. coli, K. pneumoniae und Staphylococcus aureus

1976 • 46 citations

Pharmacokinetics of meropenem in serum and suction blister fluid during continuous and intermittent infusion

1991 • 46 citations

Integration of pharmacokinetics and pharmacodynamics of methicillin in curative treatment of experimental endocarditis

1984 • 46 citations

The Recovery Period following Exposure of Bacteria to Penicillins

1979 • 46 citations

Influence of four modes of administration on penetration of aztreonam, cefuroxime, and ampicillin into interstitial fluid and fibrin clots and on in vivo efficacy against Haemophilus influenzae

1985 • 46 citations

In vitro evaluation of the determinants of bactericidal activity of ampicillin dosing regimens against Escherichia coli

1989 • 39 citations

Effects of benzylpenicillin on Streptococcus pyogenes during the postantibiotic phase in vitro

1989 • 38 citations

STUDIES ON THE PATHOGENESIS OF MENINGITIS. IV. PENICILLIN LEVELS IN THE CEREBROSPINAL FLUID IN EXPERIMENTAL MENINGITIS.

1964 • 38 citations

DYNAMICS OF THE ACTION OF PENICILLIN IN EXPERIMENTAL ANIMALS

1946 • 37 citations

The influence of the dosage regimen on the therapeutic activity of penicillin G.

1949 • 30 citations

Pharmacodynamic effects of subinhibitory antibiotic concentrations.

1990 • 28 citations

The influence of the dosage regimen on the therapeutic effectiveness of penicillin G in experimental lobar pneumonia.

1951 • 28 citations

Pharmacodynamics of beta-lactam antibiotics on gram-negative bacteria: initial killing, morphology and postantibiotic effect.

1990 • 27 citations

Evaluation of piperacillin-tazobactam in experimental meningitis caused by a beta-lactamase-producing strain of K1-positive Escherichia coli

1990 • 26 citations

Bacteriological Study on Effects of Beta-Lactam Group Antibiotics in High Concentrations

1976 • 26 citations

Effect of method of administration on extravascular penetration of four antibiotics

1982 • 26 citations

Comparative Killing Activity and Postantibiotic Effect of Streptomycin Combined with Ampicillin, Ciprofloxacin, Imipenem, Piperacillin or Vancomycin against Strains of <i>Streptococcus faecalis</i> and <i>Streptococcus faecium</i>

1988 • 23 citations

Paradoxical effects of antibiotics.

1990 • 23 citations

Time course of the pharmacological response to beta-lactam antibiotics in vitro and in vivo

1984 • 22 citations

Effects of method of antibiotic administration on extravascular penetration: cross-over study of cefazolin given by intermittent injection or constant infusion

1981 • 21 citations

Kinetics of cephaloridine in experimental wounds

1973 • 18 citations

Influence of constant infusion versus bolus injections of antibiotics on in vivo synergy

1978 • 14 citations

Pharmacokinetics and bacteriological efficacy of ticarcillin-clavulanic acid (timentin) in experimental Escherichia coli K-1 and Haemophilus influenzae type b meningitis

1987 • 14 citations

Influence of three modes of administration on the penetration of latamoxef into interstitial fluid and fibrin clots and its in-vivo activity against Haemophilus Influenzae

1986 • 9 citations

Levels of Amoxycillin in the Liquor during Continuous Intravenous Administration

1982 • 8 citations