Studying copy number variations using a nanofluidic platform

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

2005 • 4,901 citations

Global variation in copy number in the human genome

2006 • 4,228 citations

Detection of large-scale variation in the human genome

2004 • 2,876 citations

Large-Scale Copy Number Polymorphism in the Human Genome

2004 • 2,542 citations

Structural variation in the human genome

2006 • 1,980 citations

Digital PCR

1999 • 1,585 citations

2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial

2007 • 1,508 citations

The essence of SNPs

1999 • 1,316 citations

USE OF CHEMOTHERAPY PLUS A MONOCLONAL ANTIBODY AGAINST HER2 FOR METASTATIC BREAST CANCER THAT OVEREXPRESSES HER2

2009 • 1,262 citations

Mapping and sequencing of structural variation from eight human genomes

2008 • 1,132 citations

Segmental Duplications and Copy-Number Variation in the Human Genome

2005 • 955 citations

The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.

2007 • 894 citations

Pharmacogenetics and adverse drug reactions

2000 • 605 citations

Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.

1996 • 564 citations

A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome

2006 • 521 citations

Methods and strategies for analyzing copy number variation using DNA microarrays

2007 • 510 citations

ERBB2 oncogene in human breast cancer and its clinical significance

1998 • 457 citations

Genomic rearrangements and sporadic disease

2007 • 423 citations

Digital PCR for the molecular detection of fetal chromosomal aneuploidy

2007 • 410 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

Challenges and standards in integrating surveys of structural variation

2007 • 393 citations

High Throughput Gene Expression Measurement with Real Time PCR in a Microfluidic Dynamic Array

2008 • 368 citations

Real-Time Reverse Transcription–Polymerase Chain Reaction Assay for SARS-associated Coronavirus

2004 • 344 citations

Recent duplication, domain accretion and the dynamic mutation of the human genome

2001 • 332 citations

Mathematical Analysis of Copy Number Variation in a DNA Sample Using Digital PCR on a Nanofluidic Device

2008 • 284 citations

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

1991 • 273 citations

Overview of enzymes of drug metabolism

1996 • 270 citations

Ultrarapid metabolizers of debrisoquine: Characterization and PCR‐based detection of alleles with duplication of the CYP2D6 gene

1996 • 198 citations

Nanoliter scale PCR with TaqMan detection

1997 • 194 citations

Two-fold differences are the detection limit for determining transgene copy numbers in plants by real-time PCR.

2004 • 161 citations

Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P

1990 • 156 citations

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-rime PCR

2003 • 154 citations

The clinical role of genetic polymorphisms in drug-metabolizing enzymes

2007 • 138 citations

New Perspectives for the Elucidation of Genetic Disorders

2007 • 126 citations

CYP2D6 polymorphisms and the impact on tamoxifen therapy

2007 • 106 citations

Review article: the prevalence and clinical relevance of cytochrome P450 polymorphisms

2007 • 98 citations

Novel Real-Time Quantitative PCR Test for Trisomy 21

2002 • 87 citations

Prognostic and predictive value of HER2/neu oncogene in breast cancer

2002 • 84 citations

Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication

1998 • 79 citations

Recombining overlapping BACs into a single larger BAC.

2004 • 73 citations

Determination of Cytochrome P450 2D6 (CYP2D6) Gene Copy Number by Real‐Time Quantitative PCR

2005 • 70 citations

HER-2/neu Gene Copy Number Quantified by Real-Time PCR: Comparison of Gene Amplification, Heterozygosity, and Immunohistochemical Status in Breast Cancer Tissue

2003 • 65 citations

Individualized drug therapy.

2007 • 64 citations

Ongoing adjuvant trials with trastuzumab in breast cancer

2003 • 59 citations

Autosomal-Dominant Microtia Linked to Five Tandem Copies of a Copy-Number-Variable Region at Chromosome 4p16

2008 • 47 citations

HER2 testing: a review of detection methodologies and their clinical performance

2006 • 44 citations

Pharmacogenetic Screening of the Gene Deletion and Duplications of CYP2D6

2007 • 43 citations

Intracellular expression profiles measured by real-time PCR tomography in the Xenopus laevis oocyte

2007 • 34 citations

Reliability and discriminant validity of HER2 gene quantification and chromosome 17 aneusomy analysis by real-time PCR in primary breast cancer

2006 • 27 citations

DNA amplification: current technologies and applications.

2004 • 27 citations

Clinical Implications of CYP2D6 Genetic Polymorphism During Treatment with Antipsychotic Drugs

2006 • 24 citations