The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.

Drug Metabolism and Variability among Patients in Drug Response

2005 • 1,138 citations

Inheritance and Drug Response

2003 • 1,028 citations

Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition

2000 • 877 citations

CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants

2002 • 747 citations

Potential Role of Pharmacogenomics in Reducing Adverse Drug Reactions

2001 • 689 citations

Pharmacogenetics and adverse drug reactions

2000 • 605 citations

Update: Clinically Significant Cytochrome P‐450 Drug Interactions

1998 • 605 citations

Oral Erythromycin and the Risk of Sudden Death from Cardiac Causes

2004 • 508 citations

Risk for Myopathy With Statin Therapy in High-Risk Patients

2003 • 460 citations

The hypoalgesic effect of tramadol in relation to CYP2D6*

1996 • 398 citations

Interethnic Differences in Genetic Polymorphisms of CYP2D6 in the U.S. Population: Clinical Implications

2006 • 283 citations

Recent Advances: the Cytochrome P450 Enzymes

1995 • 271 citations

Extension of a Pilot Study: Impact From the Cytochrome P450 2D6 Polymorphism on Outcome and Costs Associated With Severe Mental Illness

2000 • 229 citations

Pharmacogenetics of oral anticoagulants

2003 • 199 citations

Cyp2d6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants—a pilot study

2004 • 198 citations

The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids.

1990 • 178 citations

Pharmacokinetics of losartan and its metabolite E‐3174 in relation to the CYP2C9 genotype

2002 • 175 citations

Life-Threatening Interaction of Mibefradil and β-Blockers With Dihydropyridine Calcium Channel Blockers

1998 • 156 citations

The mechanism of the interaction between amiodarone and warfarin in humans

1992 • 155 citations

Inhibition of Risperidone Metabolism by Fluoxetine in Patients With Schizophrenia: A Clinically Relevant Pharmacokinetic Drug Interaction

2002 • 129 citations

Grapefruit juice substantially increases plasma concentrations of buspirone*

1998 • 124 citations

Pharmacogenetics of the Proton Pump Inhibitors: A Systematic Review

2003 • 112 citations

Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective -demethylation and reduces the hypoalgesic effect of tramadol

2005 • 100 citations

CYP2D6 Inhibition in Patients Treated With Sertraline

1997 • 59 citations

Simvastatin-Associated Rhabdomyolysis After Coadministration of Macrolide Antibiotics in Two Patients

2007 • 45 citations

SIGNIFICANT INTERACTION BETWEEN METRONIDAZOLE AND WARFARIN

1977 • 41 citations

Compound Cardiac Toxicity of Oral Erythromycin and Verapamil

2001 • 35 citations

Prolonged Pharmacokinetic Drug Interaction Between Terbinafine and Amitriptyline

2005 • 32 citations

Diltiazem retards the metabolism of oral prednisone with effects on T‐cell markers

1999 • 23 citations

Genotyping systems for drug-metabolizing enzymes go clinical

2005 • 4 citations