Digital PCR for the molecular detection of fetal chromosomal aneuploidy

Genome sequencing in microfabricated high-density picolitre reactors

2005 • 7,594 citations

Presence of fetal DNA in maternal plasma and serum

1997 • 2,884 citations

Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis

1998 • 1,629 citations

Digital PCR

1999 • 1,585 citations

First-Trimester or Second-Trimester Screening, or Both, for Down's Syndrome

2005 • 1,045 citations

RANDOMISED CONTROLLED TRIAL OF GENETIC AMNIOCENTESIS IN 4606 LOW-RISK WOMEN

1986 • 873 citations

Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations

2003 • 808 citations

Prenatal Diagnosis of Fetal RhD Status by Molecular Analysis of Maternal Plasma

1998 • 727 citations

Microfluidic Digital PCR Enables Multigene Analysis of Individual Environmental Bacteria

2006 • 712 citations

Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection

2007 • 371 citations

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR

2006 • 361 citations

SALMONELLOSIS IN LIVESTOCK

1972 • 352 citations

Hypermethylated RASSF1A in Maternal Plasma: A Universal Fetal DNA Marker that Improves the Reliability of Noninvasive Prenatal Diagnosis

2006 • 341 citations

Detection of the placental epigenetic signature of the maspin gene in maternal plasma

2005 • 327 citations

Prenatal exclusion of β thalassaemia major by examination of maternal plasma

2002 • 261 citations

Size Separation of Circulatory DNA in Maternal Plasma Permits Ready Detection of Fetal DNA Polymorphisms

2004 • 246 citations

Prenatal diagnosis: progress through plasma nucleic acids

2006 • 193 citations

Noninvasive Prenatal Detection of Fetal Trisomy 18 by Epigenetic Allelic Ratio Analysis in Maternal Plasma: Theoretical and Empirical Considerations

2006 • 157 citations

Counting alleles to predict recurrence of early-stage colorectal cancers

2002 • 146 citations

Methods to Increase the Percentage of Free Fetal DNA Recovered From the Maternal Circulation

2004 • 140 citations

Hypermethylation of RASSF1A in Human and Rhesus Placentas

2007 • 137 citations

Assessment of Plasma DNA Levels, Allelic Imbalance, and CA 125 as Diagnostic Tests for Cancer

2002 • 137 citations

Direct molecular haplotyping of long-range genomic DNA with M1-PCR

2003 • 136 citations

Determination of RhD Zygosity: Comparison of a Double Amplification Refractory Mutation System Approach and a Multiplex Real-Time Quantitative PCR Approach

2001 • 131 citations

A non-invasive test for prenatal diagnosis based on fetal DNA present in maternal blood: a preliminary study

2007 • 128 citations

Novel Real-Time Quantitative PCR Test for Trisomy 21

2002 • 87 citations

Counting alleles reveals a connection between chromosome 18q loss and vascular invasion

2001 • 72 citations

Lack of Dramatic Enrichment of Fetal DNA in Maternal Plasma by Formaldehyde Treatment

2005 • 56 citations

Treatment of Maternal Blood Samples with Formaldehyde Does Not Alter the Proportion of Circulatory Fetal Nucleic Acids (DNA and mRNA) in Maternal Plasma

2005 • 53 citations

Detection of aneuploidies by paralogous sequence quantification

2004 • 52 citations

Impact of Formaldehyde on the in Vitro Proportion of Fetal DNA in Maternal Plasma and Serum

2004 • 30 citations

Getting more from digital SNP data

2006 • 11 citations