Hepatocyte Nuclear Factor 3 Determines the Amplitude of the Glucocorticoid Response of the Rat Tyrosine Aminotransferase Gene

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Sequence logos: a new way to display consensus sequences

1990 • 3,249 citations

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

1980 • 2,034 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

1989 • 545 citations

The interplay of DNA-binding proteins on the promoter of the mouse albumin gene

1987 • 532 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

1991 • 517 citations

Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding

1990 • 508 citations

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.

1990 • 466 citations

Mineralocorticoid and Glucocorticoid Receptor Activities Distinguished by Nonreceptor Factors at a Composite Response Element

1993 • 461 citations

Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo

1987 • 448 citations

Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter

1990 • 440 citations

A transcriptional hierarchy involved in mammalian cell-type specification

1992 • 428 citations

Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation

1992 • 411 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily

1991 • 382 citations

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.

1994 • 357 citations

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

1993 • 336 citations

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.

1993 • 329 citations

Structure refined to 2Å of a nicked DNA octanucleotide complex with DNase I

1988 • 293 citations

In vivo footprinting of rat TAT gene: Dynamic interplay between the glucocorticoid receptor and a liver-specific factor

1991 • 270 citations

A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.

1988 • 239 citations

Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter.

1988 • 236 citations

Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor

1991 • 234 citations

Enzymic Differentiation in Mammalian Liver

1969 • 213 citations

Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: induction leads to a reversible disruption of nucleosomes over an enhancer.

1991 • 206 citations

Structural Determinants of a Glucocorticoid Receptor Recognition Element

1990 • 201 citations

Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein.

1992 • 188 citations

Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements.

1993 • 187 citations

Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro.

1991 • 167 citations

Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II.

1987 • 161 citations

Transcriptional control in hepatocytes: a window on development

1991 • 128 citations

The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families.

1993 • 126 citations

Cellular factors that interact with the hepatitis B virus enhancer.

1989 • 108 citations

Site-directed mutagenesis reveals a liver transcription factor essential for the albumin transcriptional enhancer.

1990 • 103 citations

Two remote glucocorticoid responsive units interact cooperatively to promote glucocorticoid induction of rat tyrosine aminotransferase gene expression

1989 • 86 citations

Interactions of DNA-binding proteins with the 5′ region of the human transferrin gene.

1988 • 76 citations

Glucocorticoids locally disrupt an array of positioned nucleosomes on the rat tyrosine aminotransferase promoter in hepatoma cells.

1990 • 74 citations

A novel expression assay to study transcriptional activators

1990 • 68 citations

Regulation of the synthesis of tyrosine aminotransferase: the relationship to mRNATAT

1983 • 64 citations

Cell type-specific expression of the human transferrin gene

1989 • 63 citations

Mechanisms of liver-specific gene expression

1992 • 63 citations

Modulation of liver-specific transcription by interactions between hepatocyte nuclear factor 3 and nuclear factor 1 binding DNA in close apposition.

1993 • 60 citations

Purification of DNA-binding transcription factors by their selective adsorption on the affinity latex particles

1989 • 58 citations

Interplay of an original combination of factors: C/EBP, NFY, HNF3, and HNF1 in the rat aldolase B gene promoter

1991 • 56 citations

The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivation.

1992 • 51 citations

Promoter and 11-kilobase upstream enhancer elements responsible for hepatoma cell-specific expression of the rat ornithine transcarbamylase gene.

1990 • 51 citations

Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcriptional activators.

1993 • 44 citations

Liver-specific factor binding to the liver promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.

1993 • 39 citations

Participation of Ets transcription factors in the glucocorticoid response of the rat tyrosine aminotransferase gene.

1994 • 38 citations

Liver‐enriched HNF‐3α and ubiquitous factors interact with the human transferrin gene enhancer

1993 • 28 citations

The mechanism by which the human apolipoprotein B gene reducer operates involves blocking of transcriptional activation by hepatocyte nuclear factor 3.

1993 • 22 citations

A new cis-acting element involved in tissue-selective glucocorticoid inducibility of tyrosine aminotransferase gene expression.

1993 • 21 citations

Liver specific transcription factors of the HNF3-, C/EBP-and LFB1-families interact with the A-activator binding site

1991 • 15 citations

Positive and negative regulation of a transfected chimeric tyrosine aminotransferase gene: Effect of copy number

1989 • 14 citations

Nucleotide sequence of 10 kilobases of rat tyrosine aminotransferase gene 5′ flanking region

1989 • 13 citations