Proteasome-Mediated Degradation of the Papillomavirus E2-TA Protein Is Regulated by Phosphorylation and Can Modulate Viral Genome Copy Number

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Aggresomes: A Cellular Response to Misfolded Proteins

1998 • 2,116 citations

PEST sequences and regulation by proteolysis

1996 • 1,606 citations

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.

1997 • 747 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator

1990 • 396 citations

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

1996 • 365 citations

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

1993 • 329 citations

Transformation and replication in mouse cells of a bovine papillomavirus--pML2 plasmid vector that can be rescued in bacteria.

1982 • 226 citations

Intracellular Localization of Proteasomal Degradation of a Viral Antigen

1999 • 214 citations

Regulation of theXmyf-5andXmyoDExpression Pattern during Early Xenopus Development

1998 • 211 citations

The PEST Domain of IκBα Is Necessary and Sufficient forin Vitro Degradation by μ-Calpain

1999 • 193 citations

Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation

1998 • 182 citations

Long-Term Episomal Maintenance of Bovine Papillomavirus Type 1 Plasmids Is Determined by Attachment to Host Chromosomes, Which Is Mediated by the Viral E2 Protein and Its Binding Sites

1999 • 179 citations

Bovine Papillomavirus Type 1 Genomes and the E2 Transactivator Protein Are Closely Associated with Mitotic Chromatin

1998 • 178 citations

Phosphorylation Controls Timing of Cdc6p Destruction: A Biochemical Analysis

1999 • 155 citations

Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator.

1996 • 153 citations

A PEST-Like Sequence Mediates Phosphorylation and Efficient Ubiquitination of Yeast Uracil Permease

1998 • 127 citations

Interaction of the Papillomavirus E2 Protein with Mitotic Chromosomes

2000 • 119 citations

Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1.

1994 • 117 citations

The 68-kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitro

1991 • 112 citations

Bovine papilloma virus-transformed cells contain multiple E2 proteins.

1988 • 107 citations

The C terminus of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis

1991 • 104 citations

Signal-Induced Degradation of IκBα: Association with NF-κB and the PEST Sequence in IκBα Are Not Required

1996 • 90 citations

Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein

1997 • 84 citations

The measurement of ubiquitin and ubiquitinated proteins

1999 • 83 citations

Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase

1999 • 69 citations

Phosphorylation sites of the E2 transcriptional regulatory proteins of bovine papillomavirus type 1

1989 • 62 citations

Transcription Factor E2 Regulates BPV-1 DNA Replication In Vitro by Direct Protein-Protein Interaction

1991 • 53 citations

Bovine papillomavirus with a mutation in the E2 serine 301 phosphorylation site replicates at a high copy number

1991 • 44 citations

A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention

1997 • 34 citations

Induction of bovine papillomavirus E2 gene expression and early region transcription by cell growth arrest: correlation with viral DNA amplification and evidence for differential promoter induction

1990 • 27 citations

Viral Regulatory Structures and their Degeneracy

2018 • 9 citations

Regulation of the Papillomavirus E6 and E7 Oncoproteins By the Viral E1 and E2 Proteins

2018 • 4 citations