A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Epidemiologic Evidence Showing That Human Papillomavirus Infection Causes Most Cervical Intraepithelial Neoplasia

1993 • 1,236 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Human papillomaviruses in the pathogenesis of anogenital cancer

1991 • 855 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

1989 • 482 citations

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation.

1992 • 414 citations

Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

1992 • 344 citations

A quantitative in vitro focus assay for bovine papilloma virus

1980 • 324 citations

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

1991 • 311 citations

Activation of BPV-1 replication in vitro by the transcription factor E2

1991 • 284 citations

Bovine papillomavirus contains multiple transforming genes.

1985 • 283 citations

Isolation of human sequences that replicate autonomously in human cells.

1989 • 244 citations

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication

1989 • 242 citations

The E5 Transforming Gene of Bovine Papillomavirus Encodes a Small, Hydrophobic Polypeptide

1986 • 226 citations

Characterization of the Bovine Papilloma virus plasmid maintenance sequences

1984 • 224 citations

Electrospray mass spectrometry for protein characterization

1995 • 218 citations

Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus

1989 • 217 citations

Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains.

1988 • 213 citations

E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene

1986 • 206 citations

Cotranslational processing and protein turnover in eukaryotic cells

1988 • 201 citations

Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome.

1989 • 195 citations

Differential promoter utilization by the bovine papillomavirus in transformed cells and productively infected wart tissues.

1987 • 192 citations

Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.

1995 • 184 citations

E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: transactivation is mediated by the conserved amino-terminal domain.

1989 • 182 citations

PEST sequences are signals for rapid intracellular proteolysis.

1990 • 166 citations

Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator.

1996 • 153 citations

Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activity.

1986 • 151 citations

The carboxy-terminal domain shared by the bovine papillomavirus E2 transactivator and repressor proteins contains a specific DNA binding activity.

1988 • 136 citations

Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: structural and functional analysis of new viral cDNAs

1989 • 130 citations

Dissociation of transforming and trans-activation functions for bovine papillomavirus type 1

1985 • 129 citations

Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16

1991 • 126 citations

Bovine papilloma virus-transformed cells contain multiple E2 proteins.

1988 • 107 citations

Genetic analysis of the 3′ early region transformation and replication functions of bovine papillomavirus type 1

1986 • 106 citations

Isolation of Human Sequences That Replicate Autonomously in Human Cells

1989 • 100 citations

Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteins

1992 • 99 citations

A dimer of BPV-1 E2 containing a protease resistant core interacts with its DNA target.

1988 • 99 citations

Bovine papillomavirus type 1 3' early region transformation and plasmid maintenance functions

1986 • 97 citations

Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1.

1991 • 96 citations

Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIB

1995 • 91 citations

Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro.

1992 • 80 citations

Nonsense mutation in open reading frame E2 of bovine papillomavirus DNA

1986 • 79 citations

Phenotypic analysis of bovine papillomavirus type 1 E2 repressor mutants

1990 • 75 citations

Genetic assignment of multiple E2 gene products in bovine papillomavirus-transformed cells

1989 • 73 citations

Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication

1996 • 66 citations

Open reading frames E6 and E7 of bovine papillomavirus type 1 are both required for full transformation of mouse C127 cells

1989 • 65 citations

Phosphorylation sites of the E2 transcriptional regulatory proteins of bovine papillomavirus type 1

1989 • 62 citations

Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure.

1994 • 59 citations

Separation of the transcriptional activation and replication functions of the bovine papillomavirus-1 E2 protein.

1992 • 58 citations

Amino acids necessary for DNA contact and dimerization imply novel motifs in the papillomavirus E2 trans-activator.

1992 • 56 citations

Cellular control of human papillomavirus oncogene transcription

1994 • 56 citations

Transcription Factor E2 Regulates BPV-1 DNA Replication In Vitro by Direct Protein-Protein Interaction

1991 • 53 citations

Amino acids critical for the functions of the bovine papillomavirus type 1 E2 transactivator

1996 • 51 citations

Bovine papillomavirus with a mutation in the E2 serine 301 phosphorylation site replicates at a high copy number

1991 • 44 citations

Characterization of the cis elements involved in basal and E2-transactivated expression of the bovine papillomavirus P2443 promoter

1991 • 43 citations

Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene

1988 • 39 citations

Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity

1990 • 37 citations

Regulation of early gene expression from the bovine papillomavirus genome in transiently transfected C127 cells

1991 • 30 citations

Negative regulation of the bovine papillomavirus E5, E6, and E7 oncogenes by the viral E1 and E2 genes

1995 • 27 citations

The E2 transactivator of bovine papillomavirus type 1 is expressed from multiple promoters

1990 • 22 citations

Importance of the bovine papillomavirus P2443 promoter in the regulation of E2 and E5 expression

1993 • 4 citations