Microtubule Actin Cross-Linking Factor (Macf)

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration

1995 • 440 citations

Erythrocyte spectrin is comprised of many homologous triple helical segments

1984 • 418 citations

Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton.

1996 • 406 citations

Role of plectin in cytoskeleton organization and dynamics

1998 • 404 citations

Are desmosomes more than tethers for intermediate filaments?

2000 • 388 citations

Plectin deficiency results in muscular dystrophy with epidermolysis bullosa

1996 • 386 citations

Crystal Structure of the Repetitive Segments of Spectrin

1993 • 341 citations

Desmoplakin Is Required Early in Development for Assembly of Desmosomes and Cytoskeletal Linkage

1998 • 336 citations

Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions

1998 • 323 citations

Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture

1997 • 317 citations

An Essential Cytoskeletal Linker Protein Connecting Actin Microfilaments to Intermediate Filaments

1996 • 297 citations

The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau.

1989 • 294 citations

Structure of the human desmoplakins. Implications for function in the desmosomal plaque.

1990 • 275 citations

Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level.

1988 • 272 citations

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma [published erratum appears in Hum Mol Genet 1999 May;8(5):943]

1999 • 260 citations

The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1

1995 • 250 citations

Linking Integrin α6β4-based Cell Adhesion to the Intermediate Filament Cytoskeleton: Direct Interaction between the β4 Subunit and Plectin at Multiple Molecular Sites

1998 • 238 citations

The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin–Plakoglobin Complexes

1997 • 237 citations

Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy.

1996 • 227 citations

Coronin Promotes the Rapid Assembly and Cross-linking of Actin Filaments and May Link the Actin and Microtubule Cytoskeletons in Yeast

1999 • 222 citations

The plakin family: versatile organizers of cytoskeletal architecture

1997 • 211 citations

Periplakin, a Novel Component of Cornified Envelopes and Desmosomes That Belongs to the Plakin Family and Forms Complexes with Envoplakin

1997 • 206 citations

Not just scaffolding: plectin regulates actin dynamics in cultured cells

1998 • 206 citations

Cloning and sequencing of rat plectin indicates a 466-kD polypeptide chain with a three-domain structure based on a central alpha-helical coiled coil.

1991 • 188 citations

Integrators of the Cytoskeleton that Stabilize Microtubules

1999 • 176 citations

Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions.

1996 • 174 citations

Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding

1999 • 172 citations

Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin.

1996 • 167 citations

An Epidermal Plakin That Integrates Actin and Microtubule Networks at Cellular Junctions

2000 • 165 citations

Stable, detyrosinated microtubules function to localize vimentin intermediate filaments in fibroblasts.

1995 • 161 citations

Two-hybrid Analysis Reveals Fundamental Differences in Direct Interactions between Desmoplakin and Cell Type-specific Intermediate Filaments

1997 • 151 citations

Novel Features of the Light Chain of Microtubule-associated Protein MAP1B: Microtubule Stabilization, Self Interaction, Actin Filament Binding, and Regulation by the Heavy Chain

1998 • 150 citations

CLINICAL AND PATHOLOGICAL STUDIES OF AN HEREDITARY NEUROPATHY IN MICE (DYSTONIA MUSCULORUM)

1964 • 146 citations

Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin.

1987 • 144 citations

kakapo, a Gene Required for Adhesion Between and Within Cell Layers in Drosophila, Encodes a Large Cytoskeletal Linker Protein Related to Plectin and Dystrophin

1998 • 144 citations

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

1998 • 143 citations

CH domains revisited

1998 • 125 citations

Kakapo, a Novel Cytoskeletal-associated Protein Is Essential for the Restricted Localization of the Neuregulin-like Factor, Vein, at the Muscle–Tendon Junction Site

1998 • 124 citations

The kakapo Mutation Affects Terminal Arborization and Central Dendritic Sprouting of Drosophila Motorneurons

1998 • 121 citations

Gas2, a growth arrest-specific protein, is a component of the microfilament network system

1992 • 121 citations

Expression of plectin mutant cDNA in cultured cells indicates a role of COOH-terminal domain in intermediate filament association.

1993 • 117 citations

Plectin and human genetic disorders of the skin and muscle

1996 • 105 citations

Actin-binding proteins. 1: Spectrin super family.

1995 • 99 citations

The Intermediate Filament Protein Peripherin Is the Specific Interaction Partner of Mouse BPAG1-n (Dystonin) in Neurons

1999 • 91 citations

High molecular weight polypeptides (270,000-340,000) from cultured cells are related to hog brain microtubule-associated proteins but copurify with intermediate filaments.

1980 • 90 citations

Evolution of the spectrin repeat

1997 • 81 citations

Cloning and Characterization of Mouse ACF7, a Novel Member of the Dystonin Subfamily of Actin Binding Proteins

1996 • 77 citations

Molecular Cloning, Characterization, and Dynamics of Rat Formiminotransferase Cyclodeaminase, a Golgi-associated 58-kDa Protein

1998 • 76 citations

A Screen to Identify Drosophila Genes Required for Integrin-Mediated Adhesion

1998 • 74 citations

ULTRASTRUCTURAL STUDIES OF AN HEREDITARY SENSORY NEUROPATHY IN MICE (DYSTONIA MUSCULORUM

1972 • 74 citations

Pathologic changes in the CNS of Dystonia musculorum mutant mouse: An animal model for human spinocerebellar ataxia

1988 • 70 citations

Recessive epidermolysis bullosa simplex associated with plectin mutations: infantile respiratory complications in two unrelated cases

1997 • 62 citations

Identification of two distinct microtubule binding domains on recombinant rat MAP 1B.

1992 • 56 citations

Cloning and Characterization of the Neural Isoforms of Human Dystonin

1995 • 54 citations

Identification of New Members of the Gas2 and Ras Families in the 22q12 Chromosome Region

1996 • 53 citations

Novel actin crosslinker superfamily member identified by a two step degenerate PCR procedure

1995 • 46 citations

Identification of a 450-kDa Human Epidermal Autoantigen as a New Member of the Plectin Family

1996 • 46 citations

Molecular Cloning and Characterization of Human Trabeculin-α, a Giant Protein Defining a New Family of Actin-binding Proteins

1999 • 44 citations

Structure of Desmoplakin and Its Association with Intermediate Filaments

1992 • 43 citations

Molecular Cloning of Macrophin, a Human Homologue of Drosophila Kakapo with a Close Structural Similarity to Plectin and Dystrophin

1999 • 37 citations

Structure, calmodulin-binding, and calcium-binding properties of recombinant alpha spectrin polypeptides.

1991 • 31 citations

Fine structural study of the spinal cord and spinal ganglia in mice afflicted with a hereditary sensory neuropathy, dystonia musculorum.

1989 • 20 citations

cDNA Characterization and Chromosome Mapping of the Human GAS2 Gene

1998 • 17 citations