Estrogen’s bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

The role of inflammatory mediators in the pathogenesis of periodontal disease

1991 • 892 citations

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β

1996 • 799 citations

Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis

1996 • 730 citations

Skeletal Effects of Estrogen*

1994 • 722 citations

17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.

1992 • 685 citations

Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone.

1994 • 627 citations

Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells.

1991 • 558 citations

Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts

1997 • 479 citations

Cytokines and Estrogen in Bone: Anti-Osteoporotic Effects

1993 • 466 citations

Cross-Talk between Nuclear Factor-κB and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism

1998 • 405 citations

Avian osteoclasts as estrogen target cells.

1991 • 394 citations

Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts.

1986 • 392 citations

Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.

1989 • 381 citations

Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.

1996 • 371 citations

“Reprint of” A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density

2008 • 350 citations

Role of cytokines in bone resorption

1995 • 315 citations

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells

1997 • 306 citations

Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency.

1997 • 306 citations

Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis.

1987 • 303 citations

A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density

1995 • 290 citations

Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.

1994 • 247 citations

The Functional Block of TNF but Not of IL-6 Prevents Bone Loss in Ovariectomized Mice

1997 • 241 citations

Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats.

1994 • 234 citations

Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.

1994 • 206 citations

Activation of NF-κB Is Involved in the Survival of Osteoclasts Promoted by Interleukin-1

1998 • 187 citations

Interleukin-1 and bone metabolism: a review.

1993 • 183 citations

Mice Lacking the Type I Interleukin-1 Receptor Do Not Lose Bone Mass after Ovariectomy

1998 • 180 citations

Cytokines in synovial fluid. I. The presence of biologically active and immunoreactive IL-1.

1988 • 178 citations

Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in postmenopausal osteoporosis

1994 • 171 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1995 • 168 citations

Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells.

1995 • 167 citations

INTERLEUKIN-1 PRODUCTION BY ACTIVATED MACROPHAGES SURROUNDING LOOSENED ORTHOPAEDIC IMPLANTS: A POTENTIAL ROLE IN OSTEOLYSIS

1994 • 136 citations

Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement.

1995 • 131 citations

Interleukin-1 beta rather than lymphotoxin as the major bone resorbing activity in human multiple myeloma

1989 • 126 citations

Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.

1994 • 115 citations

Macrophage inflammatory protein-1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts.

1995 • 115 citations

Osteoclasts isolated from membranous bone in children exhibit nuclear estrogen and progesterone receptors

1990 • 107 citations

Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes.

1996 • 105 citations

Human Osteoclasts and Osteoclast-Like Cells Synthesize and Release High Basal and Inflammatory Stimulated Levels of the Potent Chemokine Interleukin-8¹

1998 • 105 citations

Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor

1997 • 94 citations

Cytokines and Bone Metabolism

1991 • 93 citations

Mammalian Mature Osteoclasts as Estrogen Target Cells

1996 • 93 citations

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.

1994 • 92 citations

Interleukin-1α Activates an NF-κB-like Factor in Osteoclast-like Cells

1996 • 88 citations

Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction

1997 • 80 citations

The role of cytokines in the regulation of local bone resorption.

1991 • 78 citations

Estrogen modulation of osteoclast lysosomal enzyme secretion

1995 • 77 citations

Estrogen modulation of avian osteoclast lysosomal gene expression.

1993 • 70 citations

Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression.

1993 • 67 citations

Interleukin-6 expression and histomorphometry of bones from mice deficient in receptors for interleukin-1 or tumor necrosis factor

1996 • 61 citations

Local estradiol metabolism in osteoblast- and osteoclast-like cells

1997 • 56 citations

Osteoclast-specific monoclonal antibodies coupled to magnetic beads provide a rapid and efficient method of purifying avian osteoclasts

1991 • 56 citations

Genomic organization ot the type I and type II IL-1 receptors

1995 • 55 citations

Functional estrogen receptors in a human preosteoclastic cell line.

1995 • 54 citations

Bone Marrow Changes in Adjuvant‐Induced and Collagen‐Induced Arthritis

1992 • 51 citations

Osteoclasts and transforming growth factor-beta: estrogen-mediated isoform-specific regulation of production.

1996 • 45 citations

Osteoclasts from Human Giant Cell Tumors of Bone Lack Estrogen Receptors¹

1998 • 43 citations

Osteoclasts in normal and adjuvant arthritis bone tissues express the mRNA for both type I and II interleukin-1 receptors.

1996 • 39 citations

Gingival fluid IL‐1β and IL‐6 levels in menopause

1994 • 35 citations

Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats

1993 • 33 citations

Influence of osteoclasts and osteoclast-like cells on osteoblast alkaline phosphatase activity and collagen synthesis

1994 • 31 citations

Functional estrogen in a human preosteoclastic cell line

1995 • 24 citations

[Interleukin 1 and tumor necrosis factor].

1987 • 23 citations

THREE DISTINCT PROMOTERS DIRECT TRANSCRIPTION OF DIFFERENT 5′ UNTRANSLATED REGIONS OF THE HUMAN INTERLEUKIN 1 TYPE I RECEPTOR: A POSSIBLE MECHANISM FOR CONTROL OF TRANSLATION

1996 • 18 citations

Interleukin-1α Induces a Sustained Increase in Cytosolic Free Calcium in Cultured Rabbit Osteoclasts

1993 • 13 citations

The Role of Cytokines and Growth Factors as Mediators of the Effects of Systemic Hormones at the Bone Local Level

1995 • 13 citations