Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated.

Transgenesis by means of blastocyst-derived embryonic stem cell lines.

1986 • 432 citations

Cell migration pathway in the intestinal epithelium: An in situ marker system using mouse aggregation chimeras

1985 • 187 citations

Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium.

1992 • 179 citations

Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes.

1988 • 161 citations

Studies of intestinal stem cells using normal, chimeric, and transgenic mice ¹

1992 • 153 citations

Use of transgenic mice to map cis-acting elements in the liver fatty acid-binding protein gene (Fabpl) that regulate its cell lineage-specific, differentiation-dependent, and spatial patterns of expression in the gut epithelium and in the liver acinus.

1993 • 124 citations

Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract.

1990 • 115 citations

The kinetics of villus cell populations in the mouse small intestine.

1982 • 93 citations

Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts

1992 • 86 citations

Further immunochemical studies on the combining sites of Lotus tetragonolobus and Ulex europaeus I and II lectins

1982 • 84 citations

Of fin and fur: mutational analysis of vertebrate embryonic development.

1992 • 80 citations

Use of transgenic mice to study the routing of secretory proteins in intestinal epithelial cells: analysis of human growth hormone compartmentalization as a function of cell type and differentiation.

1989 • 51 citations

Temporal and spatial patterns of transgene expression in aging adult mice provide insights about the origins, organization, and differentiation of the intestinal epithelium.

1991 • 47 citations

Expression of liver fatty acid-binding protein/human growth hormone fusion genes within the enterocyte and enteroendocrine cell populations of fetal transgenic mice.

1991 • 35 citations