Molecular Cloning and Expression of a 2-Arylpropionyl-Coenzyme A Epimerase: A Key Enzyme in the Inversion Metabolism of Ibuprofen

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

A Laboratory manual

1989 • 6,833 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Common Principles of Protein Translocation Across Membranes

1996 • 1,081 citations

The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

1988 • 383 citations

Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer

1976 • 378 citations

Structure and regulation of rat long-chain acyl-CoA synthetase.

1990 • 358 citations

The dynamic role of palmitoylation in signal transduction

1995 • 315 citations

Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats

1995 • 305 citations

Cloning and Functional Expression of a Novel Long-Chain Acyl-CoA Synthetase Expressed in Brain1

1992 • 139 citations

Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coii

1994 • 116 citations

Metabolic stereoisomeric inversion of ibuprofen in mammals

1991 • 98 citations

Mechanistic studies of the metabolic chiral inversion of (R)-ibuprofen in humans.

1989 • 86 citations

Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral α1-acid glycoprotein column

1990 • 84 citations

Purification and characterization of novel “2-arylpropionyl-CoA epimerases” from rat liver cytosol and mitochondria.

1993 • 75 citations

Metabolic inversion of (R)-ibuprofen. Formation of ibuprofenyl-coenzyme A.

1993 • 68 citations

The metabolic chiral inversion of 2-phenylpropionic acid in rat, mouse and rabbit

1986 • 64 citations

Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs—II Racemization and hydrolysis of (R)- and (S)-ibuprofen-CoA thioesters

1991 • 63 citations

Metabolic inversion of (R)-ibuprofen. Epimerization and hydrolysis of ibuprofenyl-coenzyme A.

1992 • 59 citations

Stereoselective arylpropionyl‐CoA thioester formation in vitro

1990 • 59 citations

Ibuprofen stereoisomer hepatic clearance and distribution in normal and fatty in situ perfused rat liver.

1985 • 54 citations

The role of coenzyme A in the biotransformation of 2-arylpropionic acids

1994 • 46 citations

Is the formation of R-ibuprofenyl-adenylate the first stereoselective step of chiral inversion?

1994 • 45 citations

Studies on the metabolism and chiral inversion of ibuprofen in isolated rat hepatocytes.

1990 • 40 citations

Isolation and characterization of rat liver microsomal R-ibuprofenoyl-CoA synthetase

1996 • 36 citations

Stereoselective metabolism of 2-phenylpropionic acid in rat. I. In vitro studies on the stereoselective isomerization and glucuronidation of 2-phenylpropionic acid.

1987 • 35 citations

Synthesis of l-carnitine by microorganisms and isolated enzymes

1993 • 32 citations

2-arylpropionyl-CoA epimerase: Partial peptide sequences and tissue localization

1995 • 28 citations

Microbial metabolism of 2‐arylpropionic acids: Chiral inversion of ibuprofen and 2‐phenylpropionic acid

1993 • 27 citations

Pulmonary inversion of 2‐arylpropionic acids: Influence of protein binding

1992 • 23 citations

Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells

1992 • 15 citations