Is the formation of R-ibuprofenyl-adenylate the first stereoselective step of chiral inversion?

The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

1988 • 383 citations

ACYL ADENYLATES: AN ENZYMATIC MECHANISM OF ACETATE ACTIVATION

1956 • 355 citations

The Chemical Synthesis of Amino Acyl Adenylates

1958 • 131 citations

Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral α1-acid glycoprotein column

1990 • 84 citations

Purification and characterization of novel “2-arylpropionyl-CoA epimerases” from rat liver cytosol and mitochondria.

1993 • 75 citations

OPTICAL ISOMERIZATION MECHANISM OF R (-)-HYDRATROPIC ACID DERIVATIVES

1981 • 71 citations

Metabolic inversion of (R)-ibuprofen. Formation of ibuprofenyl-coenzyme A.

1993 • 68 citations

Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs—II Racemization and hydrolysis of (R)- and (S)-ibuprofen-CoA thioesters

1991 • 63 citations

Metabolic inversion of (R)-ibuprofen. Epimerization and hydrolysis of ibuprofenyl-coenzyme A.

1992 • 59 citations

Enantiospecific formation of fenoprofen coenzyme a thioester in vitro

1988 • 54 citations

Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid.

1992 • 22 citations

Metabolic chiral inversion of flurbiprofen-CoA In vitro

1991 • 22 citations

Determination of the epimeric composition of ibuprofenyl-CoA

1991 • 21 citations

Influence of palmitate and benzoate on the unidirectional chiral inversion of ibuprofen in isolated rat hepatocytes

1992 • 15 citations