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Synthesis of l-carnitine by microorganisms and isolated enzymes

Data up to Jan 2025

Published1993
Citations32
References106

Total Citations Per Year

Abstract

References (106)

Carnitine--metabolism and functions

1983 • 1,620 citations

Molecular Mechanisms of Oxygen Activation

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CARNITINE

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Carnitine and Its Role in Fatty Acid Metabolism* *Work reviewed from this laboratory was supported by grants A-1465 and A-1682 from the National Institutes of Health.

1963 • 446 citations

Carnitine in Intermediary Metabolism

1962 • 321 citations

Stereochemical control of yeast reductions. 1. Asymmetric synthesis of L-carnitine

1983 • 318 citations

Carnitine Metabolism and Function in Humans

1986 • 249 citations

Determination of enantiomeric purity using chiral lanthanide shift reagents

1974 • 230 citations

Tissue distribution of carnitine biosynthetic enzymes in man

1980 • 228 citations

Properties of Partially Purified Carnitine Acetyltransferase

1963 • 220 citations

Carnitine

1983 • 188 citations

Enzyme in der organischen Synthese

1985 • 143 citations

Role of Lysine and ε-N-Trimethyllysine in Carnitine Biosynthesis

1973 • 135 citations

Cofactor Requirements of γ-Butyrobetaine Hydroxylase from Rat Liver

1970 • 133 citations

Zur Kenntnis der Extraktivstoffe der Muskeln. II. Mitteilung. Über das Carnitin.

1905 • 131 citations

Effects of Testosterone on the Distribution of Carnitine, Acetylcarnitine, and Carnitine Acetyltransferase in Tissues of the Reproductive System of the Male Rat

1965 • 130 citations

Protein Methylation: Chemical, Enzymological, and Biological Significance

1975 • 120 citations

Hydroxylation of γ-Butyrobetaine to Carnitine in Rat Liver*

1967 • 114 citations

The Biology of Acinetobacter

1991 • 89 citations

Stereochemical control in yeast reduction

1984 • 87 citations

Enzymatic Hydroxylations in Industrial Application

1991 • 81 citations

Comparison of the carnitine acyltransferase activities from rat liver peroxisomes and microsomes

1976 • 78 citations

Studies on the biosynthesis and turnover of carnitine

1961 • 77 citations

Mikrobielle asymmetrische Katalyse — enantioselektive Reduktion von Ketonen

1984 • 75 citations

Carnitine precursors in the rat

1962 • 75 citations

Carnitine acetyltransferase: A review of its biology, enzymology, and bioorganic chemistry

1988 • 73 citations

The preparation of crystalline carnitine acetyltransferase

1965 • 71 citations

On the steric course of baker's yeast mediated reduction of alkyl 4-azido- and 4-bromo-3-oxobutyrate. Synthesis of ()- and ()-carnitin

1985 • 68 citations

Über die Oxyaminoverbindungen, welche die Biuretreaktion zeigen. III. Spaltung derγ-Amino-β-oxy-buttersäure in die optisch-aktiven Komponenten.

1927 • 67 citations

Electrochemical Decarboxylation of Hydroxyproline: A Simple Three-Step Conversion of (2S,4R)-4-Hydroxyproline to (R)-γ-Amino-β-hydroxybutanoic Acid (GABOB)

1986 • 61 citations

Purification and properties of γ-butyrobetaine hydroxylase from Pseudomonas species AK 1

1977 • 60 citations

Localization of carnitine acetyltransferase in peroxisomes and in mitochondria of n‐alkane‐grown candida tropicalis

1978 • 54 citations

Enzymic hydrolysis of alkyl 3,4-epoxybutyrates. A new route to (R)-(-)-carnitine chloride

1988 • 54 citations

Verwertung von Trimethylammoniumverbindungen durch Acinetobacter calcoaceticus

1977 • 53 citations

Significance of renal gamma-butyrobetaine hydroxylase for carnitine biosynthesis in man.

1980 • 52 citations

Mechanism of .alpha.-ketoglutarate oxidation in coupled enzymic oxygenations

1969 • 52 citations

Synthesis of S- and R-4-Amino-3-hydroxybutyric Acid (GABOB) and S- and R-Carnitine from Arabinose or Ascorbic Acid.

1983 • 51 citations

γ-Butyrobetaine hydroxylase from Pseudomonas sp AK 1

1970 • 50 citations

Purification and properties of carnitine dehydratase from Escherichia coli — a new enzyme of carnitine metabolization

1989 • 47 citations

L‐Carnitine. Novel Synthesis and Determination of the Optical Purity

1987 • 47 citations

Stimulation of the anaerobic growth ofSalmonella typhimurium by reduction ofl-carnitine, carnitine derivatives and structure-related trimethylammonium compounds

1982 • 47 citations

Purification and Properties of Carnitine Acetyltransferase from Rat Liver1

1983 • 46 citations

Peroxisomal and Mitochondrial Carnitine Acetyltransferases in Alkane‐Grown Yeast Candida tropicalis

1982 • 45 citations

Reaction of B-alkyl-9-borabicyclo[3.3.1]nonanes with carbon monoxide in the presence of lithium tri-t-butoxyaluminohydride. The conversion of functionally substituted olefins into aldehydes via hydroboration

1969 • 44 citations

.gamma.-Butyrobetaine hydroxylase: stereochemical course of the hydroxylation reaction

1985 • 43 citations

The Formation and Degradation of Carnitine in Pseudomonas*

1967 • 42 citations

A new, short and efficient synthesis of both enantiomers of carnitine

1990 • 42 citations

Preparative Asymmetric Reduction of 3‐Ketobutyrate and ‐valerate by Suspended Cells of Thermophilic Bacteria (Thermoanaerobium brockii) in Ordinary Laboratory Equipment

1985 • 42 citations

Substrate modification as a means of enhancing the enantioselectivity of microbial reductions of .beta.-keto esters. A (R)- or (S)-1,3,5-trihydroxypentane synthon

1987 • 41 citations

Über Liebig's Fleischextrakt

1905 • 39 citations

Purification and properties of calf liver γ-butyrobetaine hydroxylase

1981 • 38 citations

Isolation and characterization of carnitine acetyltransferase from S. cerevisiae

1991 • 38 citations

Enzymatic Synthesis of l -Carnitine by Reduction of an Achiral Precursor: the Problem of Reduced Nicotinamide Adenine Dinucleotide Recycling

1980 • 36 citations

An inducible carnitine dehydrogenase from Pseudomonas aeruginosa

1967 • 36 citations

Reinigung und Eigenschaften der Carnitindehydrogenase aus Pseudomonas aeruginosa

1968 • 36 citations

Carnitine deficiency

1985 • 35 citations

Cholinesterase‐catalyzed resolution of <scp>D</scp>,<scp>L</scp>‐carnitine

1984 • 32 citations

Biochemical profile of propionyl-L-carnitine

1991 • 32 citations

Splitting of the C-N bond in carnitine by an enzyme (trimethylamine forming) from membranes ofAcinetobacter calcoaceticus

1982 • 32 citations

Stoffwechsel des l-Carnitins bei Enterobakterien

1980 • 32 citations

Formation of γ-butyrobetaine and trimethylamine from quaternary ammonium compounds structure-related to l-carnitine and choline byProteus vulgaris

1982 • 32 citations

Regulation of L‐carnitine metabolism in Escherichia coli

1987 • 31 citations

Stereoselective reduction of non-cyclic carbonyl compounds by some eumycetes

1986 • 31 citations

Uncoupling in the γ-butyrobetaine hydroxylase reaction by D=- and L=-carnitine

1982 • 31 citations

Carnitine biosynthesis in Neurospora crassa: enzymatic conversion of lysine to epsilon-N-trimethyllysine

1976 • 31 citations

Stoffwechsel des l‐Carnitins bei Enterobakterien

1980 • 31 citations

Die Darstellung von L-Carnitin und seiner Isomeren

1960 • 29 citations

Beziehungen zwischen Carnitinstoffwechsel und Fetts�ureassimilation bei Pseudomonas putida

1978 • 28 citations

Enzymic synthesis of L-acetylcarnitine and citric acid using acetyl coenzyme A recycling

1986 • 28 citations

Purification of S-adenosylmethionine: epsilon-N-L-lysine methyltransferase. The first enzyme in carnitine biosynthesis.

1977 • 27 citations

Amperometric bienzyme electrode for l-carnitine

1988 • 27 citations

Purification of clofibrate-induced carnitine acetyltransferase from rat liver mitochondria

1980 • 27 citations

Rat liver .gamma.-butyrobetaine hydroxylase catalyzed reaction: influence of potassium, substrates, and substrate analogs on hydroxylation and decarboxylation

1988 • 27 citations

Multiple forms of γ-butyrobetaine hydroxylase (EC 1.14.11.1)

1984 • 26 citations

Characterization of peroxisomal and mitochondrial carnitine acetyltransferases purified from alkane‐grown Candida tropicalis

1984 • 26 citations

A new chemical method for synthesizing and recycling acyl coenzyme A thioesters

1991 • 26 citations

γ-Butyrobetaine hydroxylase: A unique protective effect of catalase

1982 • 22 citations

Assimilation of ?-butyrobetaine, and d-and l-carnitine by resting cell suspensions of Acinetobacter calcoaceticus and Pseudomonas putida

1982 • 22 citations

A biosynthetic role for carnitine in the yeast Torulopsis bovina.

1983 • 22 citations

Carnitine acetyltransferase activity in oleaginous yeasts

1985 • 22 citations

Synthesis of l(-)-carnitine by hydration of crotonobetaine by enterobacteria

1988 • 21 citations

Racematspaltung von DL-Carnitin

1972 • 21 citations

Quantitative aspects of γ-butyrobetaine and d- and l-carnitine utilization by growing cell cultures ofAcinetobacter calcoaceticusandPseudomonas putida

1983 • 21 citations

Transport of gamma-butyrobetaine in an Agrobacterium species isolated from soil

1986 • 20 citations

Water Pollution Biology

1990 • 19 citations

Purification and properties of carnitine dehydrogenase from Pseudomonas putida

1988 • 18 citations

Bioconversion of a L-carnitin precursor in a one- or two-phase system

1991 • 16 citations

Carnitine Deficiency Revisited

1987 • 15 citations

Purification of carnitine acetyltransferase from Candida tropicalis

1982 • 11 citations

Reduktion von L-Carnitin zu γ-Butyrobetain durchEscherichia coli

1979 • 11 citations

Quantitative Bestimmung von l-Carnitin mit Hilfe von Carnitindehydrogenase aus Pseudomonas putida

1985 • 11 citations

gamma-Butyrobetaine hydroxylase and the protective role of glutathione peroxidase.

1987 • 10 citations

D,L-Carnitine resolution byFusarium oxysporum

1986 • 10 citations

Reduktion von L‐Carnitin zu γ‐Butyrobetain durch Escherichia coli

1979 • 9 citations

Influence of carnitine on the growth and productivity of murine hybridoma cells

1991 • 8 citations

Kinetische Untersuchungen zum Reaktionsmechanismus der Carnitindehydrogenase aus Pseudomonas aeruginosa

2005 • 7 citations

Detection of ligand-protein binding by direct electrophoresis of the complex

1988 • 6 citations

Characterization of a soluble carnitine acetyltransferase from Candida tropicalis

1987 • 6 citations

[Kinetic studies of the reaction mechanism of carnitine dehydrogenase of Pseudomonas aeruginosa].

1969 • 5 citations

Evidence for a role of a vicinal dithiol in the transport of γ-butyrobetaine inAgrobacterium sp.

1988 • 5 citations

Purification and properties of the gamma-butyrobetaine-binding protein from an Agrobacterium sp

1988 • 3 citations

S‐(p‐Azidophenacyl)thiocarnitine specifically binds to the γ‐butyrobetaine‐binding protein of Agrobacterium sp. and can be used as a photoaffinity label

1988 • 3 citations

Metabolism of Trimethylammonium Compounds by Acinetobacter

1991 • 1 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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