Fat: an evolving issue

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

An obesity-associated gut microbiome with increased capacity for energy harvest

2006 • 11,120 citations

‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management

2013 • 9,251 citations

Prevalence and Trends in Obesity Among US Adults, 1999-2008

2010 • 7,684 citations

The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme

1979 • 7,466 citations

Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities

2013 • 7,434 citations

Central nervous system control of food intake

2000 • 6,305 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Impact of Informing Overweight Individuals about the Role of Genetics in Obesity: An Online Experimental Study

2013 • 5,797 citations

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

2009 • 4,426 citations

XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.

1919 • 4,250 citations

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

2007 • 4,239 citations

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

2009 • 4,054 citations

Identification and Importance of Brown Adipose Tissue in Adult Humans

2009 • 4,006 citations

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

2010 • 2,887 citations

Fetal and infant growth and impaired glucose tolerance at age 64.

1991 • 2,734 citations

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 1962.

1999 • 2,323 citations

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

1999 • 1,959 citations

Reducing Children's Television Viewing to Prevent Obesity

1999 • 1,879 citations

Epigenetic Signatures of Obesity

2015 • 1,861 citations

Unexpected evidence for active brown adipose tissue in adult humans

2007 • 1,732 citations

Medical Hazards of Obesity

1993 • 1,428 citations

The Obesity-AssociatedFTOGene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

2007 • 1,425 citations

Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adults

2008 • 1,381 citations

Common variants near MC4R are associated with fat mass, weight and risk of obesity

2008 • 1,313 citations

Obesity in Britain: gluttony or sloth?

1995 • 1,202 citations

Trends over 5 Decades in U.S. Occupation-Related Physical Activity and Their Associations with Obesity

2011 • 1,166 citations

Human colonic microbiota associated with diet, obesity and weight loss

2008 • 1,166 citations

Obesity at the age of 50 y in men and women exposed to famine prenatally

1999 • 1,144 citations

Inactivation of the Fto gene protects from obesity

2009 • 911 citations

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

2010 • 768 citations

Validity of reported energy intake in obese and nonobese adolescents

1990 • 669 citations

Putative contributors to the secular increase in obesity: exploring the roads less traveled

2006 • 631 citations

Energy balance and its components: implications for body weight regulation

2012 • 628 citations

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

1999 • 603 citations

TELEVISION VIEWING AND CHILDHOOD OBESITY

2001 • 518 citations

Increased food energy supply is more than sufficient to explain the US epidemic of obesity

2009 • 510 citations

Measurements of total energy expenditure provide insights into the validity of dietary measurements of energy intake

1993 • 414 citations

Partial leptin deficiency and human adiposity

2001 • 402 citations

The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain

2008 • 374 citations

Leptin, Leptin Receptors, and the Control of Body Weight

2009 • 372 citations

Nutritional programming of the metabolic syndrome

2009 • 359 citations

Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the ‘drifty gene’ hypothesis

2008 • 334 citations

The Role of Vitamin A and Related Retinoids in Immune Function

2009 • 332 citations

Effects of endocrine disruptors on obesity

2008 • 313 citations

Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity

2011 • 285 citations

Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity

2008 • 272 citations

Physical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals

2008 • 266 citations

A Nonadaptive Scenario Explaining the Genetic Predisposition to Obesity: The “Predation Release” Hypothesis

2007 • 229 citations

Evolutionary origins of the obesity epidemic: natural selection of thrifty genes or genetic drift following predation release?

2008 • 210 citations

Increased television viewing is associated with elevated body fatness but not with lower total energy expenditure in children

2009 • 192 citations

Body weight gain in free-living Pima Indians: effect of energy intake vs expenditure

2003 • 188 citations

Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation

2012 • 175 citations

Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects

1996 • 165 citations

Metabolic Consequences and Vulnerability to Diet-Induced Obesity in Male Mice under Chronic Social Stress

2009 • 160 citations

Exploring the thrifty genotype's food-shortage assumptions: A cross-cultural comparison of ethnographic accounts of food security among foraging and agricultural societies

2006 • 137 citations

Minireview: Epigenetics of Obesity and Diabetes in Humans

2012 • 137 citations

The evolution of human adiposity and obesity: where did it all go wrong?

2012 • 122 citations

Twins and virtual twins: bases of relative body weight revisited

2002 • 106 citations

Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions

2011 • 93 citations

Why marathon migrants get away with high metabolic ceilings: towards an ecology of physiological restraint

2010 • 83 citations

Associations of Gestational Exposure to Famine with Energy Balance and Macronutrient Density of the Diet at Age 58 Years Differ According to the Reference Population Used ,

2009 • 73 citations

Energy expenditure does not predict weight change in either Nigerian or African American women

2008 • 66 citations

Adipose tissue development – Impact of the early life environment

2010 • 48 citations