Receptor Editing Can Lead to Allelic Inclusion and Development of B Cells That Retain Antibodies Reacting with High Avidity Autoantigens

de la Chapelle, A.

1997 • 3,184 citations

Predominant Autoantibody Production by Early Human B Cell Precursors

2003 • 1,966 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Defective B cell tolerance checkpoints in systemic lupus erythematosus

2005 • 677 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

T Cells Compete for Access to Antigen-Bearing Antigen-Presenting Cells

2000 • 423 citations

Self-Tolerance Checkpoints in B Lymphocyte Development

1995 • 329 citations

Contribution of Receptor Editing to the Antibody Repertoire

2001 • 312 citations

Receptor Editing in a Transgenic Mouse Model: Site, Efficiency, and Role in B Cell Tolerance and Antibody Diversification

1997 • 291 citations

Antibody regulation of B cell development

2000 • 277 citations

Revising B Cell Receptors

2000 • 261 citations

Autoreactive B Cells in the Marginal Zone that Express Dual Receptors

2002 • 260 citations

Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies

1979 • 254 citations

Receptor editing is the main mechanism of B cell tolerance toward membrane antigens

2004 • 250 citations

Developmental Regulation of B Lymphocyte Immune Tolerance Compartmentalizes Clonal Selection from Receptor Selection

1998 • 234 citations

Receptor Selection in B and T Lymphocytes

2000 • 226 citations

Repertoire selection by pre‐B‐cell receptors and B‐cell receptors, and genetic control of B‐cell development from immature to mature B cells

2000 • 216 citations

Receptor Editing Occurs Frequently during Normal B Cell Development

1998 • 205 citations

Receptor Editing, Immune Diversification, and Self-Tolerance

1996 • 197 citations

Editors and Editing of Anti-DNA Receptors

2001 • 182 citations

Epstein–Barr Virus Coopts Lipid Rafts to Block the Signaling and Antigen Transport Functions of the BCR

2001 • 159 citations

Ligand-independent Signaling Functions for the B Lymphocyte Antigen Receptor and Their Role in Positive Selection during B Lymphopoiesis

2001 • 159 citations

Src-family kinases in B-cell development and signaling

2004 • 148 citations

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest

1997 • 147 citations

The Lingering Enigma of the Allelic Exclusion Mechanism

2004 • 147 citations

A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

1993 • 144 citations

A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

1996 • 142 citations

Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells

2005 • 134 citations

Enforced Bcl-2 Expression Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose–dependent Manner and Promotes Receptor Editing in Autoreactive, Immature B Cells

1997 • 132 citations

Self-Reactive B Lymphocytes Overexpressing Bcl-xL Escape Negative Selection and Are Tolerized by Clonal Anergy and Receptor Editing

1998 • 120 citations

κ+λ+ dual receptor B cells are present in the human peripheral repertoire.

1995 • 113 citations

A Role for Nuclear Factor Kappa B/Rel Transcription Factors in the Regulation of the Recombinase Activator Genes

2005 • 84 citations

A stepwise epigenetic process controls immunoglobulin allelic exclusion

2004 • 84 citations

Frequencies of Multiple IgL Chain Gene Rearrangements in Single Normal or κL Chain–Deficient B Lineage Cells

1999 • 79 citations

B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection

2000 • 79 citations

Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at theIGL locus

2001 • 74 citations

Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: human B cells can simultaneously express cell surface kappa and lambda light chains.

1993 • 69 citations

Lack of allelic exclusion permits autoreactive B cells to escape deletion.

1994 • 67 citations

An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system

2005 • 65 citations

Autoreactive B Cells Escape Clonal Deletion by Expressing Multiple Antigen Receptors

2000 • 63 citations

Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse

2004 • 59 citations

The B Lymphocyte Adaptor Molecule of 32 Kilodaltons (Bam32) Regulates B Cell Antigen Receptor Internalization

2004 • 58 citations

Frequency and Characterization of Phenotypic Ig Heavy Chain Allelically Included IgM-Expressing B Cells in Mice

2000 • 57 citations

Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes

2000 • 54 citations

Dominant, Hierarchical Induction of Peripheral Tolerance during Foreign Antigen-Driven B Cell Development

2002 • 50 citations

A tyrosine-based signal present in Ig alpha mediates B cell receptor constitutive internalization.

1998 • 37 citations

A Tyrosine-Based Signal Present in Ig α Mediates B Cell Receptor Constitutive Internalization

1998 • 35 citations

Allelic exclusion of immunoglobulin gene rearrangement and expression: why and how?

2002 • 33 citations

Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection

2004 • 22 citations

Monoclonal origin of B cells producing k, λ and kλ immunoglobulin light chains in a patient with chronic lymphocytic leukemia

1987 • 21 citations

B cell positive selection by self antigens and counter-selection of dual B cell receptor cells in the peripheral B cell pools

2000 • 17 citations

IGMκ/λ EBV human B cell clone: An early step of differentiation of fetal B cells or A distinct B lineage?

1992 • 12 citations

Immunoglobulin kappa and lambda light chain dual genotype rearrangement in a patient with kappa-secreting B-CLL

1988 • 11 citations