Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: human B cells can simultaneously express cell surface kappa and lambda light chains.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

Monoclonal Antibodies: Principles and Practice

1996 • 928 citations

Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.

1981 • 576 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

Regulation of Hemopoiesis by Bone Marrow Stromal Cells and Their Products

1990 • 546 citations

V(D)J Recombination: Molecular Biology and Regulation

1992 • 464 citations

Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments

1980 • 402 citations

Clustered arrangement of immunoglobulin λ constant region genes in man

1981 • 379 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells

1981 • 332 citations

Cells and Molecules that Regulate B Lymphopoiesis in Bone Marrow

1989 • 272 citations

A uniform deleting element mediates the loss of κ genes in human B cells

1985 • 259 citations

The Protection: The Unit of Humoral Immunity Selected by Evolution

1990 • 236 citations

Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing

1982 • 235 citations

Studies of surface immunoglobulins on human B lymphocytes. I. Dissociation of cell-bound immunoglobulins with acid pH or at 37 degrees C.

1975 • 226 citations

Structure and expression of the human immunoglobulin lambda genes.

1990 • 163 citations

Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes

1984 • 157 citations

MECHANISM AND DEVELOPMENTAL PROGRAM OF IMMUNOGLOBULIN GENE REARRANGEMENT IN MAMMALS

1989 • 144 citations

Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin.

1991 • 140 citations

Flow cytofluorimetry: discrimination between single cells and cell aggregates by direct size measurements.

1975 • 128 citations

Normal human B cells display ordered light chain gene rearrangements and deletions.

1982 • 124 citations

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins.

1991 • 109 citations

Frequency distribution of alpha, gamma, kappa and lambda polypeptide chains in human lymphoid tissues.

1965 • 108 citations

Mu heavy chains can associate with a pseudo-light chain complex (ψL) in human pre-B cell lines

1989 • 105 citations

Development of a bone marrow culture for maintenance and growth of normal human B cell precursors.

1991 • 97 citations

Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus.

1989 • 97 citations

Polypeptide Chains of Human Gamma-Globulin: Cellular Localization by Fluorescent Antibody

1964 • 91 citations

Cytoplasmic immunoglobulin content in multiple myeloma.

1985 • 81 citations

Frequent lambda light chain gene rearrangement and expression in a Ly-1 B lymphoma with a productive kappa chain allele.

1986 • 78 citations

The kappa-deleting element. Germline and rearranged, duplicated and dispersed forms.

1988 • 61 citations

Two myeloma globulins IgG1-kappa and IgG1-lambda, from a single patient (Im). II. Their common cellular origin as revealed by immunofluorescence studies.

1974 • 51 citations

Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.

1988 • 50 citations

Precursor B cells transformed by Epstein-Barr virus undergo sterile plasma-cell differentiation: J-chain expression without immunoglobulin.

1988 • 49 citations

Active lambda and kappa antibody gene rearrangement in Abelson murine leukemia virus-transformed pre-B cell lines.

1987 • 44 citations

Differentiation of normal human pre-B cells in vitro.

1990 • 43 citations

Comparative studies on monotypic IgM lambda and IgG kappa from an individual patient. IV. Immunofluorescent evidence for a common clonal synthesis

1977 • 35 citations

Lambda-like and V pre-B genes expression: an early B-lineage marker of human leukemias

1991 • 27 citations

Structural characterization of the human B lymphocyte-restricted differentiation antigen CD22. Comparison with CD21 (complement receptor type 2/Epstein-Barr virus receptor).

1988 • 26 citations

Immunoglobulin gene rearrangements and deletions in human Epstein-Barr virus-transformed cell lines producing different IgG and IgA subclasses.

1985 • 25 citations

Double light-chain production by leukemic cells of common clonal origin: A case report with review of pertinent literature

1981 • 19 citations

Independent rearrangement of Igλ genes in tissue culture-derived murine B cell lines

1991 • 19 citations

Alternative rearrangements of immunoglobulin light chain genes in human leukemia.

1991 • 10 citations

Control of Expression of Immunoglobulin Genes

1989 • 6 citations

The Published Data

1990 • 4 citations