Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators

2000 • 807 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

1999 • 552 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Roles of Nuclear Factor κB in Neuronal Survival and Plasticity

2000 • 465 citations

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

1998 • 446 citations

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity

1998 • 444 citations

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1978 • 431 citations

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.

1995 • 426 citations

Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men.

1994 • 387 citations

Human ageing and the sympathoadrenal system

2000 • 386 citations

Circulating Levels of Allopregnanolone in Humans: Gender, Age, and Endocrine Influences

1998 • 371 citations

Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system.

1999 • 366 citations

Increased islet apoptosis in Pdx1+/– mice

2003 • 319 citations

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids

1998 • 313 citations

Increased islet apoptosis in Pdx1+/– mice

2003 • 304 citations

Dehydroepiandrosterone Activates Endothelial Cell Nitric-oxide Synthase by a Specific Plasma Membrane Receptor Coupled to Gαi2,3

2002 • 285 citations

Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage

1999 • 262 citations

Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

2001 • 222 citations

The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

2001 • 221 citations

Dehydroepiandrosterone Protects Hippocampal Neurons Against Neurotoxin‐Induced Cell Death: Mechanism of Action²

1999 • 172 citations

Stress Hormone-Related Psychopathology: Pathophysiological and Treatment Implications

2001 • 138 citations

Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly

2000 • 130 citations

Nerve Growth Factor-Induced Neurite Sprouting in PC12 Cells Involves ς-1 Receptors: Implications for Antidepressants

2002 • 124 citations

Dehydroepiandrosterone Sulfate Is Neuroprotective in a Reversible Spinal Cord Ischemia Model

2000 • 111 citations

Neuroprotection by dehydroepiandrosteronesulfate

1998 • 109 citations

The Trophic Cocktail Made by Adrenal Chromaffin Cells

1993 • 106 citations

Steroid and sterol 7-hydroxylation: ancient pathways

2002 • 105 citations

Aging is associated with changes in allopregnanolone concentrations in brain, endocrine glands and serum in male rats

1998 • 98 citations

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice

2001 • 96 citations

Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways.

2001 • 95 citations

Allopregnanolone attenuates N -methyl- d -aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture

2002 • 93 citations

Corticotropin-releasing Hormone Induces Fas Ligand Production and Apoptosis in PC12 Cells via Activation of p38 Mitogen-activated Protein Kinase

2002 • 92 citations

Dehydroepiandrosterone Modulates Nuclear Factor-κB Activation in Hippocampus of Diabetic Rats

2002 • 86 citations

Few cell lines with GABAA mRNAs have functional receptors

1994 • 84 citations

Stable transfection of PC12 cells with estrogen receptor (ERα): Protective effects of estrogen on cell survival after serum deprivation

1999 • 81 citations

Nerve Growth Factor Determines Survival and Death of PC12 Cells by Regulation of the bcl‐x, bax, and caspase‐3 Genes

1999 • 68 citations

Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor

2002 • 62 citations

Biochemical Characterization of Uracil Processing Activities in the Hyperthermophilic Archaeon Pyrobaculum aerophilum

2001 • 56 citations

Specific Binding of Dehydroepiandrosterone to the N Terminus of the Microtubule-associated Protein MAP2

2003 • 54 citations

Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration

1998 • 54 citations

Activation of σ1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures

1998 • 54 citations

An oestrogen membrane receptor participates in estradiol actions for the prevention of amyloid‐β peptide₁₋₄₀‐induced toxicity in septal‐derived cholinergic SN56 cells

2003 • 48 citations

An in Vitro Model for the Effects of Androgen on Neurons Employing Androgen Receptor-Transfected PC12 Cells

1994 • 39 citations

Comparative Study between Normal Rat Chromaffin and PC12 Rat Pheochromocytoma Cells: Production and Effects of Corticotropin-Releasing Hormone*

1997 • 38 citations

Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress.

2002 • 35 citations

An in vitro model for the effects of estrogen on neurons employing estrogen receptor-transfected PC12 cells

1994 • 34 citations

Opioids Transiently Prevent Activation of Apoptotic Mechanisms Following Short Periods of Serum Withdrawal

2000 • 34 citations

Transfer of NMDAR2 cDNAs increases endogenous NMDAR1 protein and induces expression of functional NMDA receptors in PC12 cells

2003 • 26 citations

Channel activators reduce the expression of sodium channel α-subunit mRNA in developing neurons

1996 • 16 citations

Adrenoceptor-induced changes of intracellular K+ and Ca2+ in astrocytes and neurons in rat cortical primary cultures

1997 • 13 citations