Wnt-5a/Ca²⁺-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1α Signaling in Human Mammary Epithelial Cells

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

2004 • 2,451 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Caught up in a Wnt storm: Wnt signaling in cancer

2003 • 1,473 citations

A Second Canon

2003 • 1,329 citations

NFAT Signaling

2002 • 1,316 citations

Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

2006 • 1,215 citations

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

2002 • 945 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

2001 • 826 citations

Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity

2003 • 823 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

2003 • 716 citations

Wnt and calcium signaling: β-Catenin-independent pathways

2005 • 688 citations

Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

2003 • 580 citations

The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

2005 • 535 citations

The Wnt signaling pathway and its role in tumor development

2003 • 521 citations

Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus

2000 • 497 citations

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

1997 • 493 citations

JNK functions in the non‐canonical Wnt pathway to regulate convergent extension movements in vertebrates

2002 • 444 citations

The role of NFAT transcription factors in integrin-mediated carcinoma invasion

2002 • 409 citations

Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

2002 • 405 citations

Akt Blocks Breast Cancer Cell Motility and Invasion through the Transcription Factor NFAT

2005 • 401 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

2003 • 337 citations

The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

2002 • 308 citations

Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1

1998 • 306 citations

Mechanism of Phosphorylation-Dependent Binding of APC to β-Catenin and Its Role in β-Catenin Degradation

2004 • 299 citations

Dishevelled Proteins Lead to Two Signaling Pathways

1999 • 291 citations

Biochemical interactions in the wnt pathway

2000 • 265 citations

Wnt-5a has tumor suppressor activity in thyroid carcinoma

2005 • 257 citations

The Wnts.

2001 • 257 citations

Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca2+ signaling

2001 • 217 citations

Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas.

2002 • 209 citations

Beta-catenin and Tcfs in mammary development and cancer.

2003 • 208 citations

Increasingly complex: New players enter the Wnt signaling network

2002 • 188 citations

Wnt-5a Protein Expression in Primary Dukes B Colon Cancers Identifies a Subgroup of Patients with Good Prognosis

2005 • 182 citations

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling

2003 • 181 citations

Structure of Cdc42 bound to the GTPase binding domain of PAK.

2000 • 180 citations

A Conserved Docking Motif for CK1 Binding Controls the Nuclear Localization of NFAT1

2004 • 178 citations

Tumor progression: Small GTPases and loss of cell–cell adhesion

2003 • 170 citations

Regulation of Microfilament Reorganization and Invasiveness of Breast Cancer Cells by Kinase Dead p21-activated Kinase-1

2000 • 167 citations

A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp

2000 • 156 citations

Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization

2000 • 149 citations

Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates

1999 • 148 citations

Direct Demonstration of NFATp Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFATp Polyclonal Antibody

1995 • 134 citations

Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors.

2003 • 129 citations

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1998 • 124 citations

Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells

2001 • 123 citations

Expression and Signaling Activity of Wnt-5a/Discoidin Domain Receptor-1 and Syk Plays Distinct but Decisive Roles in Breast Cancer Patient Survival

2005 • 112 citations

Epidermal Growth Factor-dependent Regulation of Cdc42 Is Mediated by the Src Tyrosine Kinase

2003 • 111 citations

Antisensewnt-5a Mimicswnt-1-Mediated C57MG Mammary Epithelial Cell Transformation

1998 • 104 citations

Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG

2004 • 104 citations

Characterisation of the phosphorylation of β-catenin at the GSK-3 priming site Ser45

2002 • 97 citations

Factor VIIa/Tissue Factor-induced Signaling via Activation of Src-like Kinases, Phosphatidylinositol 3-Kinase, and Rac

2000 • 97 citations

Wnt‐5a and G‐protein signaling are required for collagen‐induced DDR1 receptor activation and normal mammary cell adhesion

2002 • 80 citations

Endothelial Cells Stimulate T Cell NFAT Nuclear Translocation in the Presence of Cyclosporin A: Involvement of the wnt/Glycogen Synthase Kinase-3β Pathway

2002 • 76 citations

Wnt signaling and mammary tumorigenesis.

2001 • 73 citations

Actin Cytoskeleton Regulates Calcium Dynamics and NFAT Nuclear Duration

2004 • 68 citations

Analysis of combinatorial effects of Wnts and Frizzleds on β‐catenin/armadillo stabilization and Dishevelled phosphorylation

2005 • 57 citations

A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/β-catenin complex

2005 • 53 citations

Constitutively Elevated Nuclear Export Activity Opposes Ca2+-dependent NFATc3 Nuclear Accumulation in Vascular Smooth Muscle

2003 • 52 citations

Active Protein Kinase B Regulates TCR Responsiveness by Modulating Cytoplasmic-Nuclear Localization of NFAT and NF-κB Proteins

2004 • 38 citations

Basic region of residues 228-231 of protein kinase CK1? is involved in its interaction with axin: Binding to axin does not affect the kinase activity

2004 • 20 citations

Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells

1997 • 11 citations