Diminished frequency of interleukin‐10‐secreting, T‐cell receptor peptide‐reactive T cells in multiple sclerosis patients might allow expansion of activated memory T cells bearing the cognate BV gene

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.

1991 • 237 citations

Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis

1999 • 203 citations

T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis

1991 • 202 citations

Treatment of multiple sclerosis with T–cell receptor peptides: Results of a double–blind pilot trial

1996 • 176 citations

Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides.

1994 • 96 citations

Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides.

1994 • 63 citations

Defective suppressor cell function mediated by T8+ cell lines from patients with progressive multiple sclerosis.

1986 • 59 citations

T cell receptor peptides in treatment of autoimmune disease: Rationale and potential

1996 • 53 citations

Human T cell autoimmunity against myelin basic protein: CD4⁺ cells recognizing epitopes of the T cell receptor β chain from a myelin basic protein‐specific T cell clone

1993 • 49 citations

Results of a phase I clinical trial of a T-cell receptor peptide vaccine in patients with multiple sclerosis. I. Analysis of T-cell receptor utilization in CSF cell populations

1997 • 45 citations

Diversity of the anti-T-cell receptor immune response and its implications for T-cell vaccination therapy of multiple sclerosis

1998 • 28 citations

Activated suppressor cell function in multiple sclerosis — clinical correlations☆

1988 • 23 citations

Immunity to T Cell Receptor Peptides in Multiple Sclerosis. III. Preferential Immunogenicity of Complementarity-Determining Region 2 Peptides from Disease-Associated T Cell Receptor BV Genes*

1998 • 23 citations

MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR V? CDR2 peptides: Comparison with myelin basic protein-specific T cells

1996 • 16 citations

The Problems of Presentation of T Cell Receptor Peptides by Activated T Cells^a

1991 • 16 citations

Therapeutic application of T cell receptor peptides

1997 • 9 citations