Regulation of Human CD4+αβ T-Cell-Receptor-Positive (TCR+) and γδ TCR+T-Cell Responses toMycobacterium tuberculosisby Interleukin-10 and Transforming Growth Factor β

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Interleukin-10

1993 • 1,820 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Immunity to Intracellular Bacteria

1993 • 1,085 citations

Natural and synthetic non-peptide antigens recognized by human γδ T cells

1995 • 974 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands

1994 • 685 citations

Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation.

1993 • 628 citations

Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions

1989 • 592 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

IL-10 inhibits human T cell proliferation and IL-2 production.

1992 • 491 citations

Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 • 473 citations

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells

1995 • 468 citations

Activation of γδ T Cells in the Primary Immune Response to Mycobacterium tuberculosis

1989 • 463 citations

[Epidemiology of tuberculosis].

1971 • 433 citations

Cytokine production at the site of disease in human tuberculosis

1993 • 379 citations

Nonpeptide ligands for human gamma delta T cells.

1994 • 373 citations

A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein.

1990 • 331 citations

Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling

1997 • 302 citations

Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells.

1988 • 298 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Human interleukin-10 can directly inhibit T-cell growth

1993 • 283 citations

Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions.

1995 • 265 citations

Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritis.

1989 • 248 citations

Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.

1990 • 229 citations

IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor.

1992 • 229 citations

T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection.

1997 • 228 citations

Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production.

1996 • 212 citations

The use of fluorescence quenching in flow cytofluorometry to measure the attachment and ingestion phases in phagocytosis in peripheral blood without prior cell separation

1987 • 199 citations

Bacille Calmette-Guérin vaccination enhances human gamma delta T cell responsiveness to mycobacteria suggestive of a memory-like phenotype.

1998 • 185 citations

CD4+ alpha beta T cell and gamma delta T cell responses to Mycobacterium tuberculosis. Similarities and differences in Ag recognition, cytotoxic effector function, and cytokine production.

1995 • 184 citations

Early activation of human V gamma 9V delta 2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands.

1995 • 177 citations

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.

1997 • 177 citations

Enhancement Of Intracellular Growth Of Mycobacterium Tuberculosis In Human Monocytes by Transforming Growth Factor- l

1994 • 172 citations

Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.

1989 • 164 citations

Bacille Calmette-Guérin Vaccination Enhances Human γδ T Cell Responsiveness to Mycobacteria Suggestive of a Memory-Like Phenotype

1998 • 162 citations

Induction of interleukin 1 and tumor necrosis factor by mycobacterial proteins: the monocyte western blot.

1990 • 160 citations

Human immune response to Mycobacterium tuberculosis antigens

1991 • 155 citations

In vitrorestoration of T cell responses in tuberculosis and augmentation of monocyte effector function againstMycobacterium tuberculosisby natural inhibitors of transforming growth factor β

1997 • 148 citations

Selective expansion of human gamma delta T cells by monocytes infected with live Mycobacterium tuberculosis.

1991 • 138 citations

Effect of transforming growth factor-beta on early and late activation events in human T cells.

1993 • 137 citations

Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes

1991 • 134 citations

Circulating profile of Th1 and Th2 cytokines in tuberculosis patients with different degrees of pulmonary involvement

1997 • 133 citations

Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures

1992 • 133 citations

Split activity of interleukin‐10 on antigen capture and antigen presentation by human dendritic cells: Definition of a maturative step

1997 • 126 citations

Epidemiology of Tuberculosis

2006 • 105 citations

New, simple flow cytometry technique to discriminate between internalized and membrane‐bound particles in phagocytosis

1989 • 101 citations

In Vitro Synthesis of Interferon-γ, Interleukin-4, Transforming Growth Factor-β and Interleukin-1β by Peripheral Blood Mononuclear Cells from Tuberculosis Patients: Relationship with the Severity of Pulmonary Involvement

1999 • 95 citations

Role of the mononuclear phagocyte as an antigen-presenting cell for human gamma delta T cells activated by live Mycobacterium tuberculosis

1992 • 95 citations

Primary activation of V gamma 9-expressing gamma delta T cells by Mycobacterium tuberculosis. Requirement for Th1-type CD4 T cell help and inhibition by IL-10.

1994 • 94 citations

Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1.

1996 • 94 citations

Transforming growth factor‐β: An important mediator of immunoregulation

1991 • 94 citations

TGF-beta 1 is a potent inducer of human effector T cells.

1994 • 85 citations

Regulation of Interleukin‐12 by Interleukin‐10, Transforming Growth Factor‐β, Tumor Necrosis Factor‐α, and Interferon‐γ in Human Monocytes Infected withMycobacterium tuberculosisH37Ra

1998 • 82 citations

Regulation of interleukin-2 and interleukin-6 production from T-cells: Involvement of interleukin-1 β and transforming growth factor-β

1990 • 78 citations

TGF-β1 pretreatment impairs the allostimulatory function of human bone marrow-derived antigen-presenting cells for both naive and primed T cells

1996 • 72 citations

Characterization of a 10- to 14-kilodalton protease-sensitive Mycobacterium tuberculosis H37Ra antigen that stimulates human gamma delta T cells

1994 • 54 citations

The antituberculous Mycobacterium bovis BCG vaccine is an attenuated mycobacterial producer of phosphorylated nonpeptidic antigens for human gamma delta T cells

1995 • 53 citations

Differential effect of transforming growth factor-β1 on the activation of human naive and memory CD4⁺ T lymphocytes

1994 • 49 citations

Interleukin-10 increases mannose receptor expression and endocytic activity in monocyte-derived dendritic cells

1998 • 48 citations

Selective deactivation of human monocyte functions by TGF-beta.

1995 • 47 citations

Alveolar macrophages as accessory cells for human gamma delta T cells activated by Mycobacterium tuberculosis.

1995 • 37 citations

Role of a New Cytokine, Interleukin‐10, in the Cross‐Regulation of T Helper Cells

1991 • 35 citations

Processing ofMycobacterium tuberculosisBacilli by Human Monocytes for CD4⁺αβ and γδ T Cells: Role of Particulate Antigen

1998 • 33 citations

T cell response in acquired protective immunity to Mycobacterium tuberculosis infection.

1991 • 7 citations

Presence of γ/δ T-Cell receptor-expressing T cells in liver biopsies following liver transplantation

1990 • 5 citations

Tuberculosis.

1998 • 1 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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