Connective Tissue Growth Factor and Regulation of the Mesangial Cell Cycle

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Principles of CDK regulation

1995 • 3,267 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Mammalian G1 cyclins

1993 • 1,990 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

1991 • 878 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor

1996 • 754 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

1996 • 658 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

Expression of connective tissue growth factor in human renal fibrosis

1998 • 545 citations

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation

2000 • 529 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Connective Tissue Growth Factor: What's in a Name?

2000 • 483 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

1997 • 464 citations

Molecular mechanisms of diabetic renal hypertrophy

1999 • 462 citations

Fisp12/Mouse Connective Tissue Growth Factor Mediates Endothelial Cell Adhesion and Migration through Integrin α_vβ₃, Promotes Endothelial Cell Survival, and Induces Angiogenesis In Vivo

1999 • 447 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

Connective Tissue Growth Factor Induces the Proliferation, Migration, and Tube Formation of Vascular Endothelial Cells In Vitro, and Angiogenesis In Vivo

1999 • 399 citations

Suppression Subtractive Hybridization Identifies High Glucose Levels as a Stimulus for Expression of Connective Tissue Growth Factor and Other Genes in Human Mesangial Cells

1999 • 395 citations

Regulation of Connective Tissue Growth Factor Activity in Cultured Rat Mesangial Cells and Its Expression in Experimental Diabetic Glomerulosclerosis

2000 • 390 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

Viewpoint: Putting the Cell Cycle in Order

1996 • 357 citations

High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β

1992 • 353 citations

The biology of renal hypertrophy

1986 • 350 citations

Cellular events in the evolution of experimental diabetic nephropathy

1995 • 320 citations

The Drosophila Cyclin D-Cdk4 complex promotes cellular growth

2000 • 266 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect

1995 • 244 citations

Expression of transforming growth factor-β1 during diabetic renal hypertrophy

1994 • 237 citations

Differential Regulation of Retinoblastoma Tumor Suppressor Protein by G₁ Cyclin-Dependent Kinase Complexes In Vivo

2001 • 207 citations

Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy

2001 • 205 citations

The Retinoblastoma Protein: More than a Tumor Suppressor

1994 • 205 citations

Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis

2000 • 191 citations

Regulation of G1 cell-cycle progression by oncogenes and tumor suppressor genes

2002 • 188 citations

The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury

1998 • 172 citations

Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches

2001 • 166 citations

Cell-Free Degradation of p27^kip1, a G₁ Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome

1999 • 166 citations

Progression of Renal Disease and Renal Hypertrophy

1995 • 159 citations

Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?

1998 • 156 citations

From the Cover: p53 accumulates but is functionally impaired when DNA synthesis is blocked

2001 • 150 citations

Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy

2001 • 150 citations

Blood Levels of Alpha-1-Antichymotrypsin and Risk Factors for Alzheimer’s Disease: Effects of Gender and Apolipoprotein E Genotype

2000 • 141 citations

In vitro evidence for differential involvement of CTGF, TGFβ, and PDGF‐BB in mesangial response to injury

2001 • 122 citations

High Glucose-Induced Hypertrophy of Mesangial Cells Requires p27Kip1, an Inhibitor of Cyclin-Dependent Kinases

2001 • 110 citations

Static Pressure Regulates Connective Tissue Growth Factor Expression in Human Mesangial Cells

2001 • 108 citations

The cyclin kinase inhibitor p21WAF1, CIP1 is increased in experimental diabetic nephropathy

1998 • 105 citations

High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: relationship to hypertrophy

1997 • 101 citations

Cell-cycle control and renal disease

1997 • 97 citations

Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy.

1995 • 92 citations

Sodium Butyrate Induces NIH3T3 Cells to Senescence-like State and Enhances Promoter Activity of p21WAF/CIP1in p53-Independent Manner

1997 • 92 citations

Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia

1996 • 84 citations

The glomerular mesangium in diabetes mellitus

1993 • 78 citations

Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells

2000 • 77 citations

Cellular Events in Renal Hypertrophy

1989 • 73 citations

Increased MMP-2 Expression in Connective Tissue Growth Factor Over-expression Vascular Smooth Muscle Cells

2002 • 71 citations

CTGF modulates cell cycle progression in cAMP-arrested NRK fibroblasts

2000 • 66 citations

Regulation of CDKs by phosphorylation

1998 • 63 citations

TGF-β1-induced cell cycle arrest in renal mesangial cells involves inhibition of cyclin E-cdk 2 activation and retinoblastoma protein phosphorylation

1997 • 54 citations

Angiotensin converting-enzyme inhibitor treatment reduces glomerular p16 INK4 and p27 Kip1 expression in diabetic BBdp rats

1999 • 54 citations

Profiling of genes which are differentially expressed in mouse liver in response to adenoviral vectors and delivered genes

2000 • 35 citations

A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophy

1999 • 35 citations

Molecular Mechanisms of Diabetic Mesangial Cell Hypertrophy

2002 • 34 citations

Renal Hypertrophy and Kidney Disease in Diabetes

1996 • 25 citations