α-Lipoic Acid Attenuates Hyperglycemia and Prevents Glomerular Mesangial Matrix Expansion in Diabetes

Improved method for the determination of blood glutathione.

1963 • 6,733 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

1999 • 2,452 citations

Stereological Methods. Practical methods for biological morphometry

1979 • 2,038 citations

Oxidative Stress and Diabetic Vascular Complications

1996 • 1,947 citations

Alpha-lipoic acid as a biological antioxidant

1995 • 1,920 citations

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

1986 • 1,210 citations

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

2000 • 1,096 citations

Protein glycation and oxidative stress in diabetes mellitus and ageing

1991 • 882 citations

The pharmacology of the antioxidant lipoic acid

1997 • 817 citations

Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.

1997 • 701 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant

1992 • 513 citations

Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy.

1999 • 414 citations

Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid

2001 • 402 citations

Lipoic Acid Improves Nerve Blood Flow, Reduces Oxidative Stress, and Improves Distal Nerve Conduction in Experimental Diabetic Neuropathy

1995 • 377 citations

Hyperglycemia Can Cause Membrane Lipid Peroxidation and Osmotic Fragility in Human Red Blood Cells

1989 • 377 citations

High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.

1999 • 326 citations

Antioxidant Status and Lipid Peroxidation in Type II Diabetes Mellitus with and without Complications

1996 • 290 citations

Oral administration of rac-α-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial

1999 • 281 citations

α-Lipoic acid in the treatment of diabetic polyneuropathy in Germany: Current evidence from clinical trials

2009 • 220 citations

Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.

1997 • 218 citations

α-Lipoic Acid: A Multifunctional Antioxidant That Improves Insulin Sensitivity in Patients with Type 2 Diabetes

2000 • 215 citations

α-Lipoic Acid: A Metabolic Antioxidant Which Regulates NF-κB Signal Transduction and Protects Against Oxidative Injury

1998 • 205 citations

The Antioxidant α-Lipoic Acid Enhances Insulin-Stimulated Glucose Metabolism in Insulin-Resistant Rat Skeletal Muscle

1996 • 185 citations

alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.

1999 • 185 citations

Overexpression of Cu2+/Zn2+ Superoxide Dismutase Protects Against Early Diabetic Glomerular Injury in Transgenic Mice

2001 • 159 citations

Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of dl-α-lipoic acid

2000 • 144 citations

α-lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria

1999 • 143 citations

Antioxidant inhibition of protein kinase C—signaled increases in transforming growth factor-beta in mesangial cells

1997 • 134 citations

Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by α-lipoic acid in 3T3-L1 adipocytes

2000 • 133 citations

Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-beta, and glomerular size in diabetes.

1997 • 129 citations

Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats

1997 • 124 citations

Antioxidants in the serum of children with insulin-dependent diabetes mellitus

1993 • 122 citations

Effects of Dietary Supplementation of α-Lipoic Acid on Early Glomerular Injury in Diabetes Mellitus

2001 • 112 citations

Transforming Growth Factor β in Diabetic Nephropathy

1996 • 103 citations

Reduced mononuclear leukocyte ascorbic acid content in adults with insulin-dependent diabetes mellitus consuming adequate dietary vitamin C

1991 • 96 citations

Increased Resting and Exercise-Induced Oxidative Stress in Young IDDM Men

1996 • 94 citations

Transforming Growth Factor β in Diabetic Nephropathy

1996 • 85 citations

Lipid peroxidation, glutathione levels and changes in glutathione‐related enzyme activities in streptozotocin‐induced diabetic rats

1994 • 81 citations

Thromboxane in the pathogenesis of glomerular injury in diabetes

1992 • 76 citations

Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats

1999 • 57 citations

Overexpression of manganese superoxide dismutase suppresses increases in collagen accumulation induced by culture of mesangial cells in high-media glucose

2001 • 47 citations

Glutathione status, lipid peroxidation and kidney function in streptozotocin diabetic rats

1994 • 16 citations