Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

1983 • 1,555 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I

1987 • 423 citations

Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies

1981 • 417 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

A Transcriptional Activator Protein Encoded by the x- lor Region of the Human T-Cell Leukemia Virus

1985 • 346 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor

1981 • 340 citations

A quantitative in vitro focus assay for bovine papilloma virus

1980 • 324 citations

Direct transfer of cloned genes from bacteria to mammalian cells.

1980 • 291 citations

In vitro tumorigenic transformation by a defined sub-genomic fragment of bovine papilloma virus DNA

1980 • 288 citations

Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor.

1985 • 283 citations

Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity

1985 • 273 citations

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

1985 • 237 citations

Transforming growth factor(s) production enables cells to grow in the absence of serum: an autocrine system.

1982 • 219 citations

Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation

1985 • 215 citations

The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.

1984 • 214 citations

Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics.

1983 • 203 citations

Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells.

1984 • 192 citations

Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement.

1985 • 183 citations

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

1987 • 162 citations

Autocrine stimulation after transfer of the granulocyte/macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway.

1987 • 161 citations

Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.

1988 • 149 citations

T-Cell Growth Factor Gene: Lack of Expression in Human T-Cell Leukemia-Lymphoma Virus-Infected Cells

1984 • 145 citations

A rat monoclonal antibody that binds specifically to mouse T lymphoblasts and inhibits IL 2 receptor functions: a putative anti-IL 2 receptor antibody.

1984 • 121 citations

Retroviral expression of the human IL-2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity.

1987 • 103 citations

Failure of regulation of Tac antigen/TCGF receptor on adult T-cell leukemia cells by anti-Tac monoclonal antibody

1983 • 101 citations

Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type alpha transforming growth factor gene.

1987 • 100 citations

Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia

1986 • 98 citations

MSA and EGF receptors on saroma virus transformed cells and human fibrosarcoma cells in culture

1977 • 93 citations

Autocrine growth stimulation of a human T-cell lymphoma line by interleukin 2.

1985 • 86 citations

Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

1987 • 83 citations

Transfer of a cloned immunoglobulin light-chain gene to mutant hybridoma cells restores specific antibody production

1983 • 78 citations

T-Cell Growth Factor and Glucocorticoids : Opposing Regulatory Hormones in Neoplastic T-Cell Growth

1982 • 44 citations