Molecular Properties and Biological Functions of Microsomal Epoxide Hydrase

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

1973 • 825 citations

Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis

1974 • 739 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide

1971 • 414 citations

Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

1976 • 316 citations

Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid

1973 • 315 citations

Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.

1976 • 232 citations

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

1974 • 212 citations

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

1976 • 206 citations

Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.

1967 • 202 citations

High mutagenicity and toxicity of a diol epoxide derived from benzo[a]pyrene

1976 • 188 citations

Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100

1975 • 168 citations

Hepatic microsomal epoxide hydrase: a sensitive radiometric assay for hydration of arene oxides of carcinogenic aromatic hydrocarbons.

1977 • 147 citations

The apparent ubiquity of epoxide hydratase in rat organs

1977 • 145 citations

Benzo[ a ]pyrene Diol Epoxides: Mechanism of Enzymatic Formation and Optically Active Intermediates

1977 • 134 citations

Role of the arene oxide-oxepin system in the metabolism of aromatic substrates. IV. Stereochemical considerations of dihydrodiol formation and dehyrogenation

1970 • 132 citations

Kinetic analysis of the metabolism of benzo(a)pyrene to phenols, dihydrodiols, and quinones by high-pressure chromatography compared to analysis by aryl hydrocarbon hydroxylase assay, and the effect of enzyme induction.

1975 • 124 citations

Dependence of specific metabolism of benzo(a)pyrene on the inducer of hydroxylase activity.

1974 • 105 citations

Solubilization, purification, and properties of a hepatic epoxide hydrase

1971 • 105 citations

Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene

1977 • 101 citations

Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: Evidence for homologous enzymes

1971 • 100 citations

Properties of cytochrome P-450 as affected by environmental factors: Qualitative changes due to administration of polycyclic hydrocarbons

1971 • 90 citations

Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules.

1978 • 89 citations

Epoxides Derived from Various Polycyclic Hydrocarbons as Substrates of Homogeneous and Microsome‐Bound Epoxide Hydratase

1976 • 82 citations

Hepatic microsomal epoxide hydrase. Involvement of a histidine at the active site suggests a nucleophilic mechanism.

1978 • 80 citations

Mammalian Metabolism and Environmental Degradation of the Juvenoid 1-(4'-Ethylphenoxy)-3,7-dimethyl-6,7-epoxy-

1974 • 76 citations

Trans-stilbene oxide: a selective inducer of rat liver epoxide hydratase.

1978 • 69 citations

High mutagenicity of metabolically activated chrysene 1,2 dihydrodiol: Evidence for bay region activation of chrysene

1977 • 66 citations

Stereochemical course in reactions between nucleophiles and arene oxides

1974 • 62 citations

Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene 4,5-oxide

1976 • 57 citations

Effect of enzyme inducers on substrate specificity of the cytochrome P-450's.

1973 • 56 citations

Epoxide hydrase in human liver biopsy specimens: Assay and properties

1974 • 55 citations

Effect of phenobarbital and 3-methylcholanthrene administration on epoxide hydrase levels in liver microsomes

1977 • 48 citations

Mechanism of catalysis for the hydration of substituted styrene oxides by hepatic epoxide hydrase

1978 • 46 citations

Properties and amino acid composition of pure epoxide hydratase

1975 • 45 citations

Regioselectivity in enzymatic hydration of cis-1,2-disubstituted [18O]-epoxides

1978 • 41 citations

The epoxide hydratase inducer trans-stilbene oxide shifts the metabolic epoxidation of benzo(a)pyrene from the bay- to the K-region and reduces its mutagenicity.

1979 • 41 citations

Specificity of human, rat and mouse skin epoxide hydratase towards K-region epoxides of polycyclic hydrocarbons

1978 • 41 citations

Stereoselective hydrolysis of cis- and trans-stilbene oxides by hepatic microsomal epoxide hydrolase

1971 • 37 citations

Hepatic microsomal epoxide hydrase. Chemical evidence for a single polypeptide chain.

1979 • 37 citations

Purification and quantitation of preneoplastic antigen from hyperplastic nodules and normal liver.

1978 • 37 citations

Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene.

1973 • 32 citations

Stimulation of mammalian epoxide hydrase activity by flavones

1980 • 19 citations

The topology of epoxide hydratase and benzpyrene monooxygenase in the endoplasmic reticulum of rat liver

1978 • 19 citations

Enzymic hydration of benzene oxide: Assay and properties

1980 • 18 citations

Comparison of aryl hydrocarbon hydroxylase and epoxide hydratase. Induction in primary fetal rat liver cell culture

1980 • 11 citations

Mouse Liver Epoxide Hydratase: Purification and Identity with the Rat Liver Enzyme

1977 • 10 citations

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