Kinetic analysis of the metabolism of benzo(a)pyrene to phenols, dihydrodiols, and quinones by high-pressure chromatography compared to analysis by aryl hydrocarbon hydroxylase assay, and the effect of enzyme induction.

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

1973 • 2,275 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

1973 • 825 citations

Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis

1974 • 739 citations

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

1964 • 687 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

Substrate-Induced Synthesis And Other Properties Of Benzpyrene Hydroxylase In Rat Liver

1957 • 475 citations

The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states

1969 • 425 citations

<italic>In Vitro</italic> Transformation of Normal Cells to Tumor Cells by Carcinogenic Hydrocarbons<xref ref-type="fn" rid="FN2">2</xref>

1965 • 400 citations

A microsome-dependent binding of benzo[a]pyrene to DNA.

1969 • 332 citations

Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid

1973 • 315 citations

Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro

1968 • 261 citations

Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations

1970 • 252 citations

Cell‐mediated mutagenesis of mammalian cells with chemical carcinogens

1974 • 243 citations

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

1974 • 212 citations

Formation of K-region epoxides as microsomal metabolites of pyrene and benzo[a]pyrene

1972 • 199 citations

Benzo[ a ]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography

1974 • 193 citations

High-pressure liquid chromatographic analysis of benzo(alpha)pyrene metabolism and covalent binding and the mechanism of action of 7,8-benzoflavone and 1,2-epoxy-3,3,3-trichloropropane.

1974 • 175 citations

K-region and non-K-region metabolism of benzo(a)pyrene by rat liver microsomes.

1973 • 143 citations

Microsomal hydroxylases: induction and role in polycyclic hydrocarbon carcinogenesis and toxicity.

1972 • 119 citations

Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene.

1966 • 116 citations

Dependence of specific metabolism of benzo(a)pyrene on the inducer of hydroxylase activity.

1974 • 105 citations

Vitamin A compounds and analogs as inhibitors of mixed-function oxidases that metabolize carcinogenic polycyclic hydrocarbons and other compounds.

1974 • 79 citations

Metabolism of monohydroxybenzo(a)pyrenes by rat liver microsomes and mammalian cells in culture

1975 • 72 citations

Intermediary Metabolism of Benzo[<italic>α</italic>]pyrene in the Rat<xref ref-type="fn" rid="fn1">2</xref>

1962 • 66 citations

The metabolism of some aromatic hydrocarbons by mouse embryo cell cultures

1970 • 65 citations

Mechanism of the aromatization of arene oxides

1972 • 64 citations

Isolation by high pressure liquid chromatography and characterization of benzo(a)pyrene-4,5-epoxide as a metabolite of benzo(a)pyrene

1975 • 63 citations

Studies on the hydroxylation of 3,4-benzpyrene by hepatic microsomes

1970 • 60 citations

Some properties of “K-region” epoxides of polycyclic aromatic hydrocarbons

1973 • 44 citations

Benzo(a)pyrene-4,5-oxide hydratase: Assay, properties, and induction

1975 • 38 citations

Electron spin resonance study on the interaction between the chemical carcinogens and tissue components. 3. Determination of the structure of the free radical produced either by stirring 3,4-benzopyrene with albumin or incubating it wtih liver homogenates.

1968 • 20 citations