Tetracycline Repressor, tetR, rather than the tetR–Mammalian Cell Transcription Factor Fusion Derivatives, Regulates Inducible Gene Expression in Mammalian Cells

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

Crystal structure of a yeast TBP/TATA-box complex

1993 • 1,082 citations

Co-crystal structure of TBP recognizing the minor groove of a TATA element

1993 • 1,039 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

Multiple Point Mutations Affecting the Simian Virus 40 Enhancer

1983 • 883 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

MECHANISMS UNDERLYING EXPRESSION OF TN10 ENCODED TETRACYCLINE RESISTANCE

1994 • 508 citations

Initiation of Transcription by RNA Polymerase II: A Multi-step Process

1993 • 390 citations

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

1995 • 383 citations

Family of proteins that interact with TFIID and regulate promoter activity

1991 • 319 citations

Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

1987 • 293 citations

Sp1 binds to promoter sequences and activates herpes simplex virus ‘immediate-early’ gene transcription in vitro

1985 • 289 citations

Tetracycline-Reversible Silencing of Eukaryotic Promoters

1995 • 271 citations

Powerful and versatile enhancer-promoter unit for mammalian expression vectors

1986 • 263 citations

Inducible Gene Expression in Trypanosomes Mediated by a Prokaryotic Repressor

1995 • 248 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

Activation of the major immediate early gene of human cytomegalovirus by cis-acting elements in the promoter-regulatory sequence and by virus-specific trans-acting components

1985 • 245 citations

Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements

1993 • 233 citations

The cytomegalovirus enhancer: a pan-active control element in transgenic mice.

1990 • 211 citations

In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair.

1994 • 211 citations

The inducible Iac operator-repressor system is functional in mammalian cells

1987 • 207 citations

An activity specified by the osteosarcoma line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1

1995 • 179 citations

The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex.

1991 • 178 citations

Healing of partial thickness porcine skin wounds in a liquid environment

1992 • 168 citations

Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells

1988 • 152 citations

Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells

1987 • 141 citations

Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer.

1987 • 123 citations

Tn10-encoded tet repressor can regulate an operator-containing plant promoter.

1988 • 122 citations

Regulation of a modified CaMV 35S promoter by the Tn10-encoded Tet repressor in transgenic tobacco

1991 • 110 citations

RNA Polymerase II Transcription Blocked by Escherichia coli Lac Repressor

1990 • 86 citations

Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor.

1989 • 83 citations

Efficacy of tetracycline-controlled gene expression is influenced by cell type.

1995 • 79 citations

Physical interaction between the herpes simplex virus type 1 immediate-early regulatory proteins ICP0 and ICP4

1994 • 64 citations

Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro.

1988 • 56 citations

Tetracycline repressor-regulated gene repression in recombinant human cytomegalovirus

1995 • 43 citations

Establishment of a system for conditional gene expression using an inducible tRNA suppressor gene.

1992 • 42 citations

Tet repressor-tet operator contacts probed by operator DNA-modification interference studies

1988 • 31 citations

AIDS Drug: Experiencing Local Delays

1995 • 1 citations