Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8

Hox genes in vertebrate development

1994 • 2,057 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation

1996 • 774 citations

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

1997 • 690 citations

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

1990 • 684 citations

Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod

1995 • 430 citations

Variations of cervical vertebrate after expression of a Hox-1.1 transgene in mice

1990 • 371 citations

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

1992 • 364 citations

Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide.

1991 • 340 citations

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

1992 • 289 citations

Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures

1994 • 245 citations

A mutational analysis of the 5′ HoxD genes: dissection of genetic interactions during limb development in the mouse

1996 • 229 citations

Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.

1995 • 228 citations

Synpolydactyly in mice with a targeted deficiency in the HoxD complex

1996 • 210 citations

Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene

1992 • 160 citations

Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton

1996 • 154 citations

Vertebrate Hox genes and proliferation: an alternative pathway to homeosis?

1995 • 141 citations

Mutations in Paralogous Hox Genes Result in Overlapping Homeotic Transformations of the Axial Skeleton: Evidence for Unique and Redundant Function

1995 • 138 citations

Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop

1997 • 131 citations

Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide gene deletion.

1996 • 128 citations

Altering the boundaries of Hox3.1 expression: Evidence for antipodal gene regulation

1992 • 125 citations

Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster.

1988 • 119 citations

Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine Hβ58 embryonic lethal transgene insertion

1992 • 88 citations

Genetic interactions of Hox genes in limb development: learning from compound mutants

1997 • 86 citations

Regulation of Hoxc-8 during mouse embryonic development: identification and characterization of critical elements involved in early neural tube expression

1995 • 85 citations

In situ expression of collagen and proteoglycan genes in notochord and during skeletal development and growth

1994 • 79 citations

Evidence for positive and negative regulation of the Hox-3.1 gene.

1990 • 77 citations

Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice.

1993 • 66 citations

Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice.

1989 • 66 citations

Function of Homeobox Genes in SkeletAl Development

1996 • 31 citations

Spatial and temporal regulation of alacZ reporter transgene in a binary transgenic mouse system

1996 • 31 citations

Transactivation of Hox gene expression in a VP16-dependent binary transgenic mouse system

1998 • 17 citations

Functional specificity of Hoxa-4 in vertebral patterning lies outside of the homeodomain.

1996 • 16 citations

Altering the spatial determinations in the mouse embryos by manipulating the Hox genes.

1993 • 6 citations

Analysis of regulatory genes using the transgenic mouse system.

1991 • 2 citations