Agouti-related protein (83-132) is a competitive antagonist at the human melanocortin-4 receptor: no evidence for differential interactions with pro-opiomelanocortin-derived ligands

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

G-protein-coupled receptors and signaling networks: emerging paradigms

2001 • 1,005 citations

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

1993 • 844 citations

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

2001 • 564 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormonein Vivo

1998 • 555 citations

Activation of Central Melanocortin Pathways by Fenfluramine

2002 • 481 citations

AgRP(83–132) Acts as an Inverse Agonist on the Human-Melanocortin-4 Receptor

2001 • 375 citations

The Central Melanocortin System and Energy Homeostasis

1999 • 349 citations

Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade

2000 • 318 citations

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

2002 • 284 citations

Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor

2001 • 248 citations

Transgenic Expression of Syndecan-1 Uncovers a Physiological Control of Feeding Behavior by Syndecan-3

2001 • 210 citations

AgRP(83-132) Acts as an Inverse Agonist on the Human-Melanocortin-4 Receptor

2001 • 197 citations

Molecular Determinants of Ligand Binding to the Human Melanocortin-4 Receptor

2000 • 172 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

1998 • 163 citations

Structure Activity Studies of the Melanocortin-4 Receptor by in Vitro Mutagenesis: Identification of Agouti-Related Protein (AGRP), Melanocortin Agonist and Synthetic Peptide Antagonist Interaction Determinants

2001 • 150 citations

Andrenocorticotropin and β-lipotropin in the hypothalamus

1979 • 148 citations

Regulation of Melanocortin-4 Receptor Signaling: Agonist-Mediated Desensitization and Internalization

2003 • 131 citations

Investigation of the melanocyte stimulating hormones on food intake

2000 • 124 citations

Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells

2001 • 103 citations

Molecular Interaction of Agouti Protein and Agouti-Related Protein with Human Melanocortin Receptors

1998 • 98 citations

Evidence that N-acetylation regulates the behavioral activity of α-MSH in the rat and human central nervous system

1981 • 98 citations

Mutations in the Human Proopiomelanocortin Gene

2003 • 89 citations

High-Resolution NMR Structure of the Chemically-Synthesized Melanocortin Receptor Binding Domain AGRP(87−132) of the Agouti-Related Protein^,

2001 • 78 citations

Agouti-Related Protein-Like Immunoreactivity: Characterization of Release from Hypothalamic Tissue and Presence in Serum¹

2000 • 69 citations

Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the involvement of MC3 receptor in the regulation of food intake

2000 • 63 citations

Models and methods for studying insurmountable antagonism

2002 • 59 citations

Biochemical, Biophysical, and Pharmacological Characterization of Bacterially Expressed Human Agouti-Related Protein

1998 • 57 citations

Characterization of Agouti-Related Protein Binding to Melanocortin Receptors

1999 • 55 citations

Expression of Functional Melanocortin-4 Receptor in the Hypothalamic GT1-1 Cell Line

2001 • 54 citations

Differential effects of α-, β- and γ2-melanocyte-stimulating hormones on hypothalamic neuronal activation and feeding in the fasted rat

2001 • 53 citations

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

2001 • 50 citations

β-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R?

2003 • 47 citations

Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor

2002 • 46 citations

Contribution of Melanocortin Receptor Exoloops to Agouti-related Protein Binding

1999 • 46 citations

Agouti-Related Protein-Like Immunoreactivity: Characterization of Release from Hypothalamic Tissue and Presence in Serum

2000 • 33 citations

Molecular Determination of Agouti-Related Protein Binding to Human Melanocortin-4 Receptor

2003 • 31 citations

Agouti Antagonism of Melanocortin-4 Receptor: Greater Effect with Desacetyl-α-Melanocyte-Stimulating Hormone (MSH) than withα -MSH

1999 • 29 citations

C-Terminal Fragments of ACTH Stimulate Feeding in Fasted Rats

2001 • 23 citations

Agouti Antagonism of Melanocortin-4 Receptor: Greater Effect with Desacetyl- -Melanocyte-Stimulating Hormone (MSH) than with -MSH

1999 • 13 citations

Microsequencing evidence for the maturation of human proopiomelanocortin into an 18 amino acid β-melanocyte stimulating hormone [hβMSH(5–22)] in nonpituitary tissue

1989 • 10 citations