Androgens Regulate the Mammalian Homologues of Invertebrate Sex Determination Genes tra-2 and fox-1

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

1991 • 2,763 citations

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

Transport of Proteins and RNAs in and out of the Nucleus

1999 • 741 citations

SR proteins and splicing control.

1996 • 668 citations

Transcriptional activation and nuclear targeting signals of the human androgen receptor.

1991 • 611 citations

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1994 • 511 citations

Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene

1996 • 504 citations

Androgens Prevent Normally Occurring Cell Death in a Sexually Dimorphic Spinal Nucleus

1985 • 470 citations

Androgens Regulate the Dendritic Length of Mammalian Motoneurons in Adulthood

1986 • 376 citations

SEX AND THE SINGLE CELL. I. ON THE ACTION OF MAJOR LOCI AFFECTING SEX DETERMINATION IN DROSOPHILA MELANOGASTER

1980 • 355 citations

Sexual dimorphism in the vertebrate nervous system

1992 • 324 citations

SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells

1998 • 306 citations

Control of Alternative Splicing of Potassium Channels by Stress Hormones

1998 • 294 citations

Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA

1996 • 258 citations

The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene

1999 • 227 citations

The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing

1999 • 223 citations

A novel protein with RNA-binding motifs interacts with ataxin-2

2000 • 218 citations

Human Tra2 Proteins Are Sequence-Specific Activators of Pre-mRNA Splicing

1998 • 212 citations

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2

1998 • 200 citations

A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.

1990 • 198 citations

SRPK1 and Clk/Sty Protein Kinases Show Distinct Substrate Specificities for Serine/Arginine-rich Splicing Factors

1996 • 196 citations

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.

1997 • 192 citations

The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2

1994 • 182 citations

Regulation of Sex-Specific Selection of fruitless 5′ Splice Sites by transformerand transformer-2

1998 • 176 citations

A family with adult spinal and bulbar muscular atrophy, X-linked inheritance and associated testicular failure

1983 • 170 citations

Efficient Cloning of cDNAs of Retinoic Acid-Responsive Genes in P19 Embryonal Carcinoma Cells and Characterization of a Novel Mouse Gene, Stra1 (Mouse LERK-2/Eplg2)

1995 • 169 citations

In Vivo Regulation of Alternative Pre-mRNA Splicing by the Clk1 Protein Kinase

1997 • 169 citations

The Clk2 and Clk3 Dual-Specificity Protein Kinases Regulate the Intranuclear Distribution of SR Proteins and Influence Pre-mRNA Splicing

1998 • 134 citations

A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions.

1996 • 131 citations

Testosterone differentially regulates the regenerative properties of injured hamster facial motoneurons

1991 • 128 citations

Protein Phosphorylation Plays an Essential Role in the Regulation of Alternative Splicing and Sex Determination in Drosophila

1998 • 115 citations

X-chromosome-counting mechanisms that determine nematode sex

1997 • 110 citations

Androgen insensitivity

1999 • 96 citations

Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster.

1987 • 95 citations

A Cell Culture Model for Androgen Effects in Motor Neurons

1998 • 94 citations

Administration of testosterone attenuates neuronal loss following axotomy in the brain-stem motor nuclei of female rats

1989 • 94 citations

Familial bulbo-spinal muscular atrophy associated with testicular atrophy and sensory neuropathy (Kennedy-Alter-Sung syndrome)

1988 • 92 citations

Characterization of an Expanded Glutamine Repeat Androgen Receptor in a Neuronal Cell Culture System

1997 • 89 citations

SR protein kinases: the splice of life

1999 • 88 citations

X‐linked spinomuscular atrophy

1992 • 83 citations

Identification of a candidate primary sex determination locus, fox-1, on the X chromosome of Caenorhabditis elegans

1994 • 78 citations

Molecular defects of the androgen receptor

1999 • 64 citations

The regulation of sex determination and sexually dimorphic differentiation in Drosophila

1993 • 62 citations

Problems and paradigms: Genetic sex determination mechanism and evolution

1992 • 60 citations

Genetic and Molecular Analysis of fox-1, a Numerator Element Involved in Caenorhabditis elegans Primary Sex Determination

1999 • 56 citations

Androgen receptor mutation in Kennedy'sdisease

1999 • 47 citations

A Negative Feedback Mechanism Revealed by Functional Analysis of the Alternative Isoforms of the Drosophila Splicing Regulator transformer-2

1996 • 38 citations