Resting, and rate‐dependent depression of of guinea‐pig ventricular action potentials by amiodarone and desethylamiodarone

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

A Classification of Antiarrhythmic Actions Reassessed After a Decade of New Drugs

1984 • 808 citations

The effect of amiodarone, a new anti-anginal drug, on cardiac muscle

1970 • 553 citations

Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs

1984 • 544 citations

Amiodarone pharmacokinetics

1983 • 397 citations

Side effects of long-term amiodarone therapy.

1983 • 364 citations

Clinical Pharmacokinetics of Amiodarone

1984 • 310 citations

Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification

1983 • 279 citations

Amiodarone: Electrophysiologic actions, pharmacokinetics and clinical effects

1984 • 236 citations

Side effects and complications of amiodarone therapy

1985 • 217 citations

Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone.

1984 • 213 citations

Antiarrhythmic efficacy and electrophysiologic actions of amiodarone in patients with life-threatening ventricular arrhythmias: Potent suppression of spontaneously occurring tachyarrhythmias versus inconsistent abolition of induced ventricular tachycardia

1982 • 176 citations

The adrenergic antagonism of amiodarone

1976 • 165 citations

Antiarrhythmic drug action. Blockade of the inward sodium current.

1984 • 163 citations

Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction.

1980 • 142 citations

Interval-dependent effects of small antiarrhythmic drugs on excitability of guinea-pig myocardium

1980 • 138 citations

Amiodarone blocks inactivated cardiac sodium channels

1983 • 120 citations

Structure-activity relations for frequency-dependent sodium channel block in nerve by local anesthetics.

1980 • 114 citations

Resting and Rate-Dependent Depression of Maximum Rate of Depolarisation (Vmax) in Guinea Pig Ventricular Action Potentials by Mexiletine, Disopyramide, and Encainide

1983 • 99 citations

Effects of Amiodarone and its Metabolite, Desethylamiodarone, on the Electrophysiologic Properties of Isolated Cardiac Muscle

1986 • 96 citations

Importance of physico‐chemical properties in determining the kinetics of the effects of Class I antiarrhythmic drugs on maximum rate of depolarization in guinea‐pig ventricle

1983 • 86 citations

The relation of Vmax to INa, GNa, and h infinity in a model of the cardiac Purkinje fiber

1979 • 81 citations

PH-Dependent effects of quinidine on the kinetics of dV/dtmax in guinea pig ventricular myocardium.

1982 • 79 citations

Use-dependent effects of amiodarone on V̇max in cardiac Purkinje and ventricular muscle fibers

1985 • 56 citations

Electrophysiologic effects of chronic amiodarone therapy in patients with ventricular arrhythmias

1982 • 49 citations

Pharmacodynamic studies of amiodarone and its active N-desethyl metabolite.

1986 • 38 citations

Mexiletine in isolated tissue models.

1977 • 37 citations

High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in small tissue samples after enzymatic digestion.

1983 • 36 citations

Time-independent effects on cardiac action potential upstroke velocity (resting block) and lipid solubility of beta adrenergic blockers

1981 • 18 citations

Measurement of Vmax of the cardiac action potential with a sample/hold peak detector

1978 • 10 citations

VOLTAGE‐ AND TIME‐DEPENDENT DEPRESSION OF MAXIMUM RATE OF DEPOLARIZATION OF GUINEA‐PIG VENTRICULAR ACTION POTENTIALS BY TWO STEROIDAL ANTIARRHYTHMIC DRUGS, CCI 22277 AND ORG 6001

1982 • 8 citations