Desethylamiodarone Prolongation of Cardiac Repolarization is Dependent on Gene Expression: A Novel Antiarrhythmic Mechanism

The effect of amiodarone, a new anti-anginal drug, on cardiac muscle

1970 • 553 citations

Cellular electropharmacology of amiodarone

1997 • 330 citations

Hsp70 expression in human skeletal muscle after exercise

1996 • 159 citations

Amiodarone

1992 • 154 citations

Pharmacology and Pharmacokinetics of Amiodarone

1991 • 123 citations

The Molecular Biology of Thyroid Hormone Action

1995 • 121 citations

Antiarrhythmic Actions of Amiodarone: A Profile of a Paradoxical Agent

1996 • 120 citations

Amiodarone blocks calcium current in single guinea pig ventricular myocytes.

1989 • 114 citations

The Effects of Amiodarone on Serum Thyroid Hormones and Hepatic Thyroxine 5′-Monodeiodination in Rats*

1983 • 110 citations

Amiodarone-induced block of sodium current in isolated cardiac cells.

1987 • 99 citations

Effects of Amiodarone and its Metabolite, Desethylamiodarone, on the Electrophysiologic Properties of Isolated Cardiac Muscle

1986 • 96 citations

Comparative electrophysiologic effects of intravenous amiodarone and desethylamiodarone in dogs: evidence for clinically relevant activity of the metabolite.

1987 • 79 citations

Alterations of Ca2+ uptake and Ca2+-activated ATPase of cardiac sarcoplasmic reticulum in hyper- and hypothyroidism

1971 • 77 citations

Events in the cardiac arrhythmia suppression trial (CAST): Mortality in the entire population enrolled

1991 • 75 citations

Interaction of amiodarone and desethylamiodarone with solubilized nuclear thyroid hormone receptors

1987 • 72 citations

Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein.

1994 • 68 citations

Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone α1-receptor protein

1995 • 61 citations

Cardiac β-adrenoceptor modulation by amiodarone

1983 • 60 citations

Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries.

1992 • 56 citations

Electrophysiologic effects of desethylamiodarone, an active metabolite of amiodarone: Comparison with amiodarone during chronic administration in rabbits

1988 • 53 citations

The antiarrhythmic efficacy of amiodarone and desethylamiodarone, alone and in combination, in dogs with acute myocardial infarction.

1988 • 52 citations

Amiodarone Decreases Cardiac β-Adrenoceptors Through an Antagonistic Effect on 3,5,3′ Triiodothyronine

1992 • 36 citations

Amiodarone Reduces the Effect of T3 on Beta Adrenergic Receptor Density in Rat Heart

1990 • 32 citations

Block of cardiac sodium channels by amiodarone studied by using of action potential in single ventricular myocytes

1991 • 30 citations

Amiodarone Decreases Na,K-ATPase α2 and β2 Expression Specifically in Cardiac Ventricle

1994 • 28 citations

Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein

1994 • 28 citations

Amiodarone Is a Dose-Dependent Noncompetitive and Competitive Inhibitor of T3 Binding to Thyroid Hormone Receptor Subtype β1, Whereas Disopyramide, Lignocaine, Propafenone, Metoprolol, dl-Sotalol, and Verapamil Have No Inhibitory Effect

1995 • 28 citations

Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries

1992 • 26 citations

Voltage- and Use-Dependent Modulation of Calcium Channel Current in Guinea Pig Ventricular Cells by Amiodarone and Des-Oxo-Amiodarone

1991 • 21 citations

Amiodarone antagonizes the effects of T₃ at the receptor level: An additional mechanism for its in vivo hypothyroid-like effects

1991 • 21 citations

Comparison of acute electrophysiological effects of amiodarone and its metabolite desethylamiodarone in Langendorff perfused guinea pig hearts

1991 • 17 citations

Models for the binding of amiodarone to the thyroid hormone receptor

1992 • 14 citations

Downregulation of Thyroid Hormone Receptor Subtype mRNA Levels by Amiodarone during Catecholamine Stress in Vitro

1995 • 12 citations

Regulation of α- and β-myosin heavy chain messenger RNAs in the rat myocardium by amiodarone and by thyroid status

1989 • 12 citations

Effects of chronic amiodarone treatment on human myocardial adrenoceptor density and adenylate cyclase response

1991 • 9 citations

— A new, potent class III antiarrhythmic agent

1990 • 5 citations

Acute effects of amiodarone on ultrastructure and electrical activity of isolated guinea pig hearts

1991 • 5 citations