Overexpression of HER2/neu oncogene in human pancreatic carcinoma

TNM Classification of Malignant Tumours

1987 • 16,209 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Rapid transfer of DNA from agarose gels to nylon membranes

1985 • 1,810 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.

1992 • 500 citations

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness.

1993 • 413 citations

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer

1991 • 375 citations

Intermolecular association of the p185 protein and EGF receptor modulates EGF receptor function

1990 • 362 citations

Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 • 335 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

1989 • 316 citations

Pancreatic Islet-Acinar Cell Interaction: Amylase Messenger RNA Levels Are Determined By Insulin

1981 • 274 citations

Prognostic significance of her‐2/neu expression in breast cancer and its relationship to other prognostic factors

1991 • 262 citations

Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer.

1986 • 192 citations

The c‐erbB‐2 proto‐oncogene in human pancreatic cancer

1990 • 172 citations

p53 Mutations are common in pancreatic cancer and are absent in chronic pancreatitis

1993 • 170 citations

Expression of ERBB2 in human gastric carcinomas: relationship between p185ERBB2 expression and the gene amplification.

1990 • 162 citations

Gene amplification in gastric and esophageal adenocarcinomas.

1990 • 155 citations

HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

1989 • 144 citations

Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues.

1988 • 134 citations

c‐erbB‐2 oncogene product staining in gastric adenocarcinoma. An immunohistochemical study

1989 • 97 citations

Microvascular abnormalities of the portal hypertensive gastric mucosa

1988 • 97 citations

Oncogene expression in human leukemia

1984 • 87 citations

c‐erbB‐2 proto‐oncogene expression and its relationship to survival in gastric carcinoma: An immunohistochemical study on archival material

1991 • 79 citations

Inverse relationship of epidermal growth factor receptor and HER2/neu gene expression in human renal cell carcinoma.

1990 • 77 citations

Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products.

1988 • 76 citations

The neu‐oncogene protein as a predictive factor for haematogenous metastases in breast cancer patients

1990 • 75 citations

Characterization of a neu/c-erbB-2 protein-specific activating factor.

1991 • 66 citations

The immunohistochemical expressions of epidermal growth factors, epidermal growth factor receptors and c-erbB-2 oncoprotein in human pancreatic cancer.

1992 • 43 citations

Update on Pancreatic Cancer

1988 • 13 citations

The use of computer-assisted video image analysis in the enumeration of immuno-stained cells in tissue sections

1990 • 13 citations