Impaired growth and elevated Fas receptor expression in PIGA+ stem cells in primary paroxysmal nocturnal hemoglobinuria

Meta-analysis in clinical trials

1986 • 36,193 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria

1993 • 1,033 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

The Pathophysiology of Acquired Aplastic Anemia

1997 • 522 citations

Distribution of decay-accelerating factor in the peripheral blood of normal individuals and patients with paroxysmal nocturnal hemoglobinuria.

1985 • 408 citations

Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals

1999 • 403 citations

Lymphoid and myeloid differentiation of single human CD34+, HLA-DR+, CD38- hematopoietic stem cells

1994 • 314 citations

Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression

2000 • 248 citations

Aplastic Anemia: Acquired and Inherited

1994 • 245 citations

Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria

1996 • 238 citations

The problem of clonality in aplastic anemia: Dr Dameshek's riddle, restated [see comments]

1992 • 222 citations

Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria.

1993 • 188 citations

The problem of clonality in aplastic anemia: Dr Dameshek's riddle, restated [see comments]

1992 • 175 citations

Blast cell colony assay for umbilical cord blood and adult bone marrow progenitors

1987 • 152 citations

Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.

1997 • 138 citations

Monoclonal antibodies capable of causing hemolysis of neuraminidase-treated human erythrocytes by homologous complement.

1989 • 128 citations

Biosynthesis of glycosylphosphatidylinositol membrane anchors

1995 • 124 citations

Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1- murine lymphoma mutants.

1992 • 112 citations

Impaired Hematopoiesis in Paroxysmal Nocturnal Hemoglobinuria/Aplastic Anemia Is Not Associated With a Selective Proliferative Defect in the Glycosylphosphatidylinositol-Anchored Protein-Deficient Clone

1997 • 107 citations

Resistance to apoptosis caused byPIG-Agene mutations in paroxysmal nocturnal hemoglobinuria

1997 • 105 citations

Apoptosis Resistance of Blood Cells From Patients With Paroxysmal Nocturnal Hemoglobinuria, Aplastic Anemia, and Myelodysplastic Syndrome

1997 • 100 citations

Genetic defects underlying paroxysmal nocturnal hemoglobinuria that arises out of aplastic anemia

1995 • 94 citations

Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O ⁶ -benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

1996 • 83 citations

CD64/Fc gamma RI is a granulo-monocytic lineage marker on CD34+ hematopoietic progenitor cells

1995 • 68 citations

Herpes simplex virus type 2 inhibition of Fas ligand expression

1996 • 61 citations

Expression of the DAF (CD55) and CD59 antigens during normal hematopoietic cell differentiation

1992 • 61 citations

Leukemia Arising out of Paroxysmal Nocturnal Hemoglobinuria

1999 • 60 citations

The PIG-A Mutation and Absence of Glycosylphosphatidylinositol-Linked Proteins Do Not Confer Resistance to Apoptosis in Paroxysmal Nocturnal Hemoglobinuria

1998 • 60 citations

Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice

1996 • 56 citations

Fas ligand deficiency in HIV disease

1997 • 48 citations

The molecular basis for paroxysmal nocturnal hemoglobinuria

1993 • 47 citations

Transforming Growth Factor-β1 Abrogates Fas-Induced Growth Suppression and Apoptosis of Murine Bone Marrow Progenitor Cells

1997 • 47 citations

Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells

1996 • 45 citations

Defective and normal haematopoietic stem cells in paroxysmal nocturnal haemoglobinuria

1993 • 45 citations

Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells

1996 • 43 citations

Peripheral blood harvest of unaffected CD34+ CD38- hematopoietic precursors in paroxysmal nocturnal hemoglobinuria

1995 • 33 citations

Viral regulation of CD95 expression and apoptosis in T lymphocytes.

1997 • 28 citations

Paroxysmal nocturnal hemoglobinuria: molecular pathogenesis and molecular therapeutic approaches.

1998 • 20 citations

Research directions in paroxysmal nocturnal hemoglobinuria

1999 • 16 citations

Both Paroxysmal Nocturnal Hemoglobinuria (PNH) Type II Cells and PNH Type III Cells Can Arise From Different Point Mutations Involving the Same Codon of the PIG-A Gene

1997 • 15 citations

Induction of Lytic Pathways in T Cell Clones Derived from Wild‐type or Protein Tyrosine Kinase Fyn Mutant Mice

1995 • 11 citations