Genetic defects underlying paroxysmal nocturnal hemoglobinuria that arises out of aplastic anemia

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria

1993 • 1,033 citations

Distribution of decay-accelerating factor in the peripheral blood of normal individuals and patients with paroxysmal nocturnal hemoglobinuria.

1985 • 408 citations

Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene.

1994 • 390 citations

Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for severe acquired aplastic anemia

1995 • 329 citations

Late haematological complications in severe aplastic anaemia

1988 • 286 citations

Abnormalities of PIG-A Transcripts in Granulocytes from Patients with Paroxysmal Nocturnal Hemoglobinuria

1994 • 249 citations

The molecular basis of paroxysmal nocturnal hemoglobinuria

1995 • 231 citations

Long‐term follow‐up of severe aplastic anaemia patients treated with antithymocyte globulin

1989 • 201 citations

The treatment of severe acquired aplastic anemia

1995 • 190 citations

Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria.

1993 • 188 citations

A pathogenetic link between aplastic anemia and paroxysmal nocturnal hemoglobinuria is suggested by a high frequency of aplastic anemia patients with a deficiency of phosphatidylinositol glycan anchored proteins.

1995 • 159 citations

Aplastic anemia and paroxysmal nocturnal hemoglobinuria: search for a pathogenetic link

1995 • 130 citations

Monoclonal antibodies capable of causing hemolysis of neuraminidase-treated human erythrocytes by homologous complement.

1989 • 128 citations

Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1- murine lymphoma mutants.

1992 • 112 citations

Mutations within the Piga gene in patients with paroxysmal nocturnal hemoglobinuria

1994 • 95 citations

Relationship between decay accelerating factor deficiency, diminished acetylcholinesterase activity, and defective terminal complement pathway restriction in paroxysmal nocturnal hemoglobinuria erythrocytes.

1987 • 83 citations

Somatic mutations of the PIG-A gene found in Japanese patients with paroxysmal nocturnal hemoglobinuria

1995 • 77 citations

The molecular basis for paroxysmal nocturnal hemoglobinuria

1993 • 47 citations

Impaired Glycosylation of Glycosylphosphatidylinositol-Anchor Synthesis in Paroxysmal Nocturnal Hemoglobinuria Leukocytes

1993 • 37 citations

PIG‐A, DAF and proto‐oncogene expression in paroxysmal nocturnal haemoglobinuria‐associated acute myelogenous leukaemia blasts

1995 • 25 citations

Regulation of glycoinositol phospholipid anchor assembly in human lymphocytes. Absent mannolipid synthesis in affected T and natural killer cell lines from paroxysmal nocturnal hemoglobinuria patients.

1993 • 24 citations

Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells.

1994 • 7 citations