Evidence for Common Structural Determinants of Human Immunodeficiency Virus Type 1 Coreceptor Activity Provided through Functional Analysis of CCR5/CXCR4 Chimeric Coreceptors

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals

1997 • 1,373 citations

Tyrosine Sulfation of the Amino Terminus of CCR5 Facilitates HIV-1 Entry

1999 • 688 citations

In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression

1997 • 642 citations

Evidence for Cell-Surface Association Between Fusin and the CD4-gp120 Complex in Human Cell Lines

1996 • 367 citations

Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding

1997 • 363 citations

Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function

1999 • 349 citations

Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation

1994 • 343 citations

Regions in β-Chemokine Receptors CCR5 and CCR2b That Determine HIV-1 Cofactor Specificity

1996 • 298 citations

Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.

1991 • 272 citations

Molecular Interactions of Cyclam and Bicyclam Non-peptide Antagonists with the CXCR4 Chemokine Receptor

2001 • 260 citations

Identification of Residues of CXCR4 Critical for Human Immunodeficiency Virus Coreceptor and Chemokine Receptor Activities

2000 • 234 citations

Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions

1999 • 229 citations

Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1

1997 • 218 citations

Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry

1998 • 218 citations

Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses

1994 • 204 citations

Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains

1997 • 192 citations

A Tyrosine-Rich Region in the N Terminus of CCR5 Is Important for Human Immunodeficiency Virus Type 1 Entry and Mediates an Association between gp120 and CCR5

1998 • 192 citations

Highly Potent RANTES Analogues either Prevent CCR5-Using Human Immunodeficiency Virus Type 1 Infection In Vivo or Rapidly Select for CXCR4-Using Variants

1999 • 185 citations

HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5

1997 • 183 citations

Beyond Receptor Expression: The Influence of Receptor Conformation, Density, and Affinity in HIV-1 Infection

2000 • 180 citations

Constitutive cell surface association between CD4 and CCR5

1999 • 179 citations

Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity

1997 • 177 citations

Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity

1997 • 176 citations

Changing Virus‐Host Interactions in the Course of HIV‐1 Infection

1994 • 157 citations

Multiple Charged and Aromatic Residues in CCR5 Amino-terminal Domain Are Involved in High Affinity Binding of Both Chemokines and HIV-1 Env Protein

1999 • 153 citations

Determinants for Sensitivity of Human Immunodeficiency Virus Coreceptor CXCR4 to the Bicyclam AMD3100

1998 • 142 citations

A Tyrosine-sulfated Peptide Based on the N Terminus of CCR5 Interacts with a CD4-enhanced Epitope of the HIV-1 gp120 Envelope Glycoprotein and Inhibits HIV-1 Entry

2000 • 140 citations

Alanine Substitutions of Polar and Nonpolar Residues in the Amino-Terminal Domain of CCR5 Differently Impair Entry of Macrophage- and Dualtropic Isolates of Human Immunodeficiency Virus Type 1

1998 • 128 citations

Analysis of the Critical Domain in the V3 Loop of Human Immunodeficiency Virus Type 1 gp120 Involved in CCR5 Utilization

1999 • 122 citations

Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists.

2000 • 109 citations

A biosensor assay for studying ligand-membrane receptor interactions: Binding of antibodies and HIV-1 Env to chemokine receptors

2000 • 109 citations

T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use

1998 • 108 citations

Shift of Clinical Human Immunodeficiency Virus Type 1 Isolates from X4 to R5 and Prevention of Emergence of the Syncytium-Inducing Phenotype by Blockade of CXCR4

1999 • 107 citations

N-Linked Glycosylation of CXCR4 Masks Coreceptor Function for CCR5-Dependent Human Immunodeficiency Virus Type 1 Isolates

2000 • 106 citations

HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.

1997 • 102 citations

Mutagenesis of CXCR4 Identifies Important Domains for Human Immunodeficiency Virus Type 1 X4 Isolate Envelope-Mediated Membrane Fusion and Virus Entry and Reveals Cryptic Coreceptor Activity for R5 Isolates

1999 • 95 citations

Effect of Mutations in the Second Extracellular Loop of CXCR4 on Its Utilization by Human and Feline Immunodeficiency Viruses

1999 • 93 citations

Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses

1997 • 83 citations

CC Chemokine Receptor 5-Mediated Signaling and HIV-1 Co-receptor Activity Share Common Structural Determinants

1997 • 79 citations

The Amino Terminus of Human CCR5 Is Required for Its Function as a Receptor for Diverse Human and Simian Immunodeficiency Virus Envelope Glycoproteins

1998 • 63 citations

Viral Entry through CXCR4 Is a Pathogenic Factor and Therapeutic Target in Human Immunodeficiency Virus Type 1 Disease

2000 • 62 citations

Entry of R5X4 and X4 Human Immunodeficiency Virus Type 1 Strains Is Mediated by Negatively Charged and Tyrosine Residues in the Amino-Terminal Domain and the Second Extracellular Loop of CXCR4

2000 • 58 citations

The HTLV Receptor Is a Widely Expressed Protein

2000 • 54 citations

CXCR4 Sequences Involved in Coreceptor Determination of Human Immunodeficiency Virus Type-1 Tropism

1998 • 48 citations

HIV and SIV gp120 Binding Does Not Predict Coreceptor Function

1999 • 45 citations

Substitutions in a Homologous Region of Extracellular Loop 2 of CXCR4 and CCR5 Alter Coreceptor Activities for HIV-1 Membrane Fusion and Virus Entry

2000 • 43 citations

Relationship between Productive HIV-1 Infection of Macrophages and CCR5 Utilization

1999 • 20 citations

CCR5 HIV-1 Coreceptor Activity

1999 • 20 citations