Substitutions in a Homologous Region of Extracellular Loop 2 of CXCR4 and CCR5 Alter Coreceptor Activities for HIV-1 Membrane Fusion and Virus Entry

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

1998 • 1,595 citations

HIV Entry and Its Inhibition

1998 • 1,270 citations

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

1995 • 1,252 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule

1992 • 769 citations

Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)

1985 • 718 citations

HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain

1990 • 589 citations

Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution

1992 • 501 citations

Co-receptors for HIV-1 entry

1997 • 493 citations

Arrangement of rhodopsin transmembrane α-helices

1997 • 449 citations

Compact, Synthetic, Vaccinia Virus Early/Late Promoter for Protein Expression

1997 • 394 citations

Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding

1997 • 363 citations

An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

1992 • 353 citations

Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function

1999 • 349 citations

Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation

1994 • 343 citations

Chemokine receptors: Structure, function and role in microbial pathogenesis

1996 • 329 citations

Multiple Extracellular Elements of CCR5 and HIV-1 Entry: Dissociation from Response to Chemokines

1996 • 314 citations

Regions in β-Chemokine Receptors CCR5 and CCR2b That Determine HIV-1 Cofactor Specificity

1996 • 298 citations

Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy

1995 • 278 citations

Unwelcomed Guests with Master Keys: How HIV Uses Chemokine Receptors for Cellular Entry

1997 • 260 citations

Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions

1999 • 229 citations

Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains

1997 • 223 citations

Differential Inhibition of Human Immunodeficiency Virus Type 1 Fusion, gp120 Binding, and CC-Chemokine Activity by Monoclonal Antibodies to CCR5

1999 • 222 citations

Projection structure of frog rhodopsin in two crystal forms.

1995 • 220 citations

Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1

1997 • 218 citations

Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry

1998 • 218 citations

Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses

1997 • 209 citations

HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor

1997 • 203 citations

A Tyrosine-Rich Region in the N Terminus of CCR5 Is Important for Human Immunodeficiency Virus Type 1 Entry and Mediates an Association between gp120 and CCR5

1998 • 192 citations

Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains

1997 • 192 citations

HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5

1997 • 183 citations

Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent

1997 • 183 citations

The Second Extracellular Loop of CCR5 Is the Major Determinant of Ligand Specificity

1997 • 183 citations

Constitutive cell surface association between CD4 and CCR5

1999 • 179 citations

Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity

1997 • 177 citations

Identification and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity

1998 • 167 citations

Regulated expression of foreign genes in vaccinia virus under the control of bacteriophage T7 RNA polymerase and the Escherichia coli lac repressor

1992 • 158 citations

Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication

1999 • 152 citations

Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophages.

1995 • 146 citations

Alanine Substitutions of Polar and Nonpolar Residues in the Amino-Terminal Domain of CCR5 Differently Impair Entry of Macrophage- and Dualtropic Isolates of Human Immunodeficiency Virus Type 1

1998 • 128 citations

Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5

1999 • 127 citations

Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages

1996 • 126 citations

The Block to HIV-1 Envelope Glycoprotein-Mediated Membrane Fusion in Animal Cells Expressing Human CD4 Can Be Overcome by a Human Cell Component(s)

1993 • 124 citations

Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion

1997 • 122 citations

Extracellular Cysteines of CCR5 Are Required for Chemokine Binding, but Dispensable for HIV-1 Coreceptor Activity

1999 • 118 citations

Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line

1993 • 107 citations

N-Linked Glycosylation of CXCR4 Masks Coreceptor Function for CCR5-Dependent Human Immunodeficiency Virus Type 1 Isolates

2000 • 106 citations

HIV-1 envelope determinants for cell tropism and chemokine receptor use

1999 • 102 citations

Mutagenesis of CXCR4 Identifies Important Domains for Human Immunodeficiency Virus Type 1 X4 Isolate Envelope-Mediated Membrane Fusion and Virus Entry and Reveals Cryptic Coreceptor Activity for R5 Isolates

1999 • 95 citations

Effect of Mutations in the Second Extracellular Loop of CXCR4 on Its Utilization by Human and Feline Immunodeficiency Viruses

1999 • 93 citations

A Critical Site in the Core of the CCR5 Chemokine Receptor Required for Binding and Infectivity of Human Immunodeficiency Virus Type 1

1999 • 85 citations

Multiple Residues Contribute to the Inability of Murine CCR-5 To Function as a Coreceptor for Macrophage-Tropic Human Immunodeficiency Virus Type 1 Isolates

1998 • 69 citations

A monoclonal antibody (12G5) directed against CXCR-4 inhibits infection with the dual-tropic human immunodeficiency virus type 1 isolate HIV-1(89.6) but not the T-tropic isolate HIV-1(HxB)

1997 • 68 citations

Role of the Amino-Terminal Extracellular Domain of CXCR-4 in Human Immunodeficiency Virus Type 1 Entry

1997 • 64 citations

The Amino Terminus of Human CCR5 Is Required for Its Function as a Receptor for Diverse Human and Simian Immunodeficiency Virus Envelope Glycoproteins

1998 • 63 citations

Structure–function studies of the HIV-1 coreceptors

1998 • 61 citations

Chemokine receptors and human immunodeficiency virus infection

1998 • 57 citations

CD4-independent utilization of the CXCR4 chemokine receptor by HIV-1 and HIV-2

1998 • 55 citations

HIV coreceptors, cell tropism and inhibition by chemokine receptor ligands

1999 • 53 citations

CCR5-Mediated Human Immunodeficiency Virus Entry Depends on an Amino-Terminal gp120-Binding Site and on the Conformational Integrity of All Four Extracellular Domains

1999 • 51 citations

CXCR4 Sequences Involved in Coreceptor Determination of Human Immunodeficiency Virus Type-1 Tropism

1998 • 48 citations

HIV Coreceptors

1998 • 29 citations

The second extracellular loop of CXCR4 is involved in CD4-independent entry of human immunodeficiency virus type 2.

1998 • 28 citations

HIV And Membrane Receptors

1997 • 25 citations

Evolution of Neutralizing Antibody Response against HIV Type 1 Virions and Pseudovirions in Multicenter AIDS Cohort Study Participants

1998 • 24 citations

CCR5 HIV-1 Coreceptor Activity

1999 • 20 citations