THE MECHANISM OF LYMPHOCYTE‐MEDIATED CYTOTOXICITY

Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity

1974 • 1,161 citations

Cytotoxic Effects of Lymphoid Cells in Vitro

1969 • 643 citations

Natural Killer Cells: Characteristics and Regulation of Activity

1979 • 582 citations

GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO

1974 • 488 citations

Studies of allograft immunity in mice. I. Induction, development and in vitro assay of cellular immunity.

1970 • 266 citations

Target-effector interaction in the natural killer (NK) cell system. II. The isolation of NK cells and studies on the mechanism of killing.

1978 • 266 citations

Mechanism of Specific Tumor-Cell Lysis by Alloimmune T Lymphocytes: Resolution and Characterization of Discrete Steps in the Cellular Interaction

1977 • 258 citations

Cytotoxic Effects of Antigen- and Mitogen-Induced T Cells on Various Targets

1975 • 224 citations

Cellular Antibodies in Kidney Homotransplantation

1960 • 206 citations

EFFECT OF ANTIBODY AND COMPLEMENT ON PERMEABILITY CONTROL IN ASCITES TUMOR CELLS AND ERYTHROCYTES

1959 • 204 citations

Quantitative in vitro assay of cytotoxic cellular immunity.

1970 • 196 citations

QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO

1965 • 182 citations

Target-Effector Interaction in the Natural Killer (NK) Cell System

1978 • 162 citations

Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes: conjugation, killing and recycling at the single cell level

1975 • 158 citations

The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases.

1980 • 155 citations

The mechanism of T cell mediated cytotoxicity II. morphological studies of cell death by time-lapse microcinematography

1976 • 146 citations

Action of cytochalasin D on cells of established lines. III. Zeiosis and movements at the cell surface.

1975 • 140 citations

NATURE OF LYMPHOCYTE-TUMOR INTERACTION

1973 • 136 citations

Quantitative analysis of the 51Cr release cytotoxicity assay for cytotoxic lymphocytes

1974 • 134 citations

Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.

1980 • 119 citations

Cell-mediated immunity and the major histocompatibility complex

1978 • 119 citations

Kinetic analysis of target cell destruction by effector T cells. I. Delineation of parameters related to the frequency and lytic efficiency of killer cells.

1976 • 117 citations

Ultrastructure of membrane lesions in immune lysis, osmotic lysis and drug-induced lysis.

1974 • 109 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. II. The use of various target cell markers to study cytolytic events.

1973 • 107 citations

Mechanism of cell-mediated cytotoxicity at the single cell level. II. Evidence for first-order kinetics of T cell-mediated cytolysis and for heterogeneity of lytic rate.

1979 • 103 citations

Mechanisms of immune lysis. I. Physiological distinction between target cell death mediated by cytotoxic T lymphocytes and antibody plus complement.

1980 • 101 citations

Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis

1978 • 97 citations

Cytotoxic T Lymphocyte Sequential Killing of Immobilized Allogeneic Tumor Target Cells Measured by Time-Lapse Microcinematography

1978 • 96 citations

Natural killing (NK) and antibody-dependent cellular cytotoxicity (ADCC) in specific pathogen-free (SPF) miniature swine and germfree piglets. I. Comparison of NK and ADCC.

1980 • 91 citations

Lysis of Antibody-Treated Human Erythrocytes by Human Leukocytes and Macrophages in Tissue Culture

1972 • 86 citations

The micromorphology of zeiotic blebs in cultured human epithelial (HEp) cells

1967 • 85 citations

Target-effector cell interaction in the natural killer cell system. V. Energy requirements, membrane integrity, and the possible involvement of lysosomal enzymes.

1980 • 82 citations

Characterization of natural killer (NK) cells and killer (K) cells in human blood: Discrimination between NK and K cell activities

1978 • 82 citations

Non-specific cytotoxicity by T cells activated with plant mitogens in vitro and the requirement for plant agents during the killing reaction.

1973 • 81 citations

The mechanism of T-cell mediated cytotoxicity. VI. T-cell projections and their role in target cell killing.

1979 • 81 citations

Kinetic Analysis of Target Cell Destruction by Effector T Cells

1976 • 75 citations

Different effector cell types in antibody-dependent cell-mediated cytotoxicity

1975 • 74 citations

Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity

1974 • 70 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. XI. The role of lectin in lectin-dependent cell-mediated cytotoxicity.

1978 • 68 citations

CYTOTOXIC REACTIONS OF MOUSE ISO-ANTISERA: PRELIMINARY CONSIDERATIONS.

1964 • 66 citations

An Effector-Cell Independent Step in Target Cell Lysis by Sensitized Mouse Lymphocytes

1973 • 66 citations

MULTIPLE TARGET CELL KILLING BY THE CYTOLYTIC T LYMPHOCYTE AND THE MECHANISM OF CYTOTOXICITY

1976 • 66 citations

Observations on the mechanism by which T-lymphocytes exert cytotoxic effects

1974 • 66 citations

REJECTION OF ASCITES TUMOR ALLOGRAFTS

1972 • 65 citations

Contact regions of cytotoxic T lymphocyte-target cell conjugates

1976 • 63 citations

Morphological observations on the contact‐induced lysis of target cells

1973 • 63 citations

Permeability changes induced in erthrocyte ghost targets by antibody-dependent cytotoxic effector cells: evidence for membrane pores.

1980 • 62 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. IX. Relationships between antigen recognition and lytic expression in killer T cells.

1977 • 62 citations

Kinetic analysis of a graft reaction induced in cell culture.

1969 • 60 citations

Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis.

1977 • 60 citations

T cell‐mediated cytotoxicity: Discrimination between antigen recognition, lethal hit and cytolysis phase

1974 • 59 citations

Ultrastructural changes during T-lymphocyte-mediated cytolysis

1977 • 59 citations

The Elution of 51Cr from Labelled Leukocytes —a New Theory

1969 • 58 citations

Immune T lymphocyte to tumor cell adhesion. Magnesium sufficient, calcium insufficient.

1980 • 58 citations

Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. III. Resolution of two distinct roles for calcium in the cytolytic process.

1979 • 57 citations

The mechanism of T cell mediated cytotoxicity V. Morphological studies by electron microscopy

1977 • 56 citations

Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells

1978 • 54 citations

Studies on the mechanism of T cell-mediated lysis at the single effector cell level. I. Kinetic analysis of lethal hits and target cell lysis in multicellular conjugates.

1979 • 54 citations

Studies on the induction and expression of T cell-mediated immunity

1979 • 54 citations

Tumor Immunity in vitro: Destruction of a Mouse Ascites Tumor through a Cycling Pathway

1972 • 54 citations

Studies on the Synthetic Capacity and Antigenic Expression of Glutaraldehyde-Fixed Target Cells

1975 • 53 citations

Evidence for direct linkage between antigen recognition and lytic expression in effector T cells.

1976 • 53 citations

The effect of organophosphorus inhibitors, p-nitrophenol and cytochalasin B on cytotoxic killing of tumour cells by immune spleen cells, and the effect of shaking.

1972 • 53 citations

Cytolytic T Lymphocytes Recognize Alloantigens on Schistosomula of Schistosoma Mansoni, but Fail to Induce Damage

1979 • 52 citations

Intercellular communication in cell‐mediated cytotoxicity. Fluorescein transfer between H‐2^d target cells and H‐2^b lymphocytes in vitro

1971 • 51 citations

The uptake and retention of chromium by cells.

1976 • 50 citations

The mechanism of T cell mediated cytotoxicity I. The release of different cell components

1976 • 49 citations

QUANTITATIVE ASSESSMENT OF CELLULAR AND HUMORAL RESPONSES TO SKIN AND TUMOR ALLOGRAFTS

1971 • 48 citations

Interruption of the Sequential Release of Small and Large Molecules from Tumor Cells by Low Temperature During Cytolysis Mediated by Immune T-Cells or Complement

1974 • 47 citations

Augmentation of Human K‐Cell Activity with Interferon

1980 • 47 citations

Studies on the Mechanism of Lymphocyte-Mediated Cytolysis

1978 • 47 citations

Mechanism of Cell-Mediated Cytotoxicity at the Single Cell Level

1979 • 47 citations

Comparative Studies on the Mechanisms of Nonspecific, Con A-Dependent Cytolysis and Specific T Cell-Mediated Cytolysis

1977 • 45 citations

Estimation of the size of a T-cell-induced lytic lesion

1974 • 44 citations

Inhibition of mammalian cytotoxic cells by phosphatidylcholine and its analogue

1975 • 44 citations

Studies on the Mechanism of T Cell-Mediated Lysis at the Single Effector Cell Level

1979 • 44 citations

Contact areas of cytotoxic lymphocytes and target cells

1975 • 44 citations

Presidential address to the American Association of Immunologists, delivered in Chicago, Illinois, April 6, 1977. Mechanism of cytolysis by lymphocytes: A comparison with complement.

1977 • 43 citations

Lectin-induced nonlethal adhesions between cytolytic T lymphocytes and antigenically unrecognizable tumor cells and nonspecific "triggering" of cytolysis.

1980 • 40 citations

T Lymphocyte-Mediated Cytolysis: Dissociation of the Binding and Lytic Mechanisms of the Effector Cell

1978 • 40 citations

Mechanism of target cell lysis by cytolytic T lymphocytes. Characterization of specific lymphocyte‐target cell conjugates separated by velocity sedimentation

1977 • 40 citations

Separation of Effector Cells Mediating Antibody-Dependent Cellular Cytotoxicity (ADC) to Erythrocyte Targets from Those Mediating ADC to Tumor Targets

1976 • 37 citations

Limited specific T-cell mediated cytolysis in the absence of extracellular Ca2+.

1980 • 36 citations

Allograft immunity in the mouse. 1. Quantitation and specificity of cytotoxic effector cells after in vitro sensitization.

1973 • 36 citations

A comparison of the cytotoxic activity of eosinophils and other cells by 51 chromium release and time lapse microcinematography.

1978 • 34 citations

Target Cell Recognition by Cytolytic T Cells: Different Requirements for the Formation of Strong Conjugates or for Proceeding to Lysis

1979 • 34 citations

Studies of the induction and expression of T cell mediated immunity. VI. Heterogeneity of lytic efficiency exhibited by isolated cytotoxic T lymphocytes prepared from highly enriched populations of effector-target conjugates.

1977 • 34 citations

Lysis of tumor cells by antibody and complement. VII. Complement-dependent 86Rb release--a nonlethal event?

1976 • 33 citations

Energy metabolism and T-cell-mediated cytolysis. II. Selective inhibition of cytolysis by 2-deoxy-D-glucose.

1977 • 33 citations

Interpretation of 51Cr-Release Data: A Kinetic Analysis

1978 • 32 citations

Mechanism of Complement-Induced Cell Lysis Demonstration of a Three-Step Mechanism of EAC1-8 Cell Lysis by C9 and of a Non-Osmotic Swelling of Erythrocytes

1975 • 31 citations

Distribution and Valence State of Radiochromium in Intracellularly Labeled Ehrlich Mouse Ascites Carcinoma Cells.

1958 • 30 citations

Antibody-dependent cytolytically active human leukocytes: an analysis of inactivation following in vitro interaction with antibody-coated target cells.

1975 • 29 citations

Changes in Fluorescence Polarization of a Membrane Probe during Lymphocyte-Target Cell Interaction

1978 • 29 citations

Distinction between C8-mediated and C8/C9-mediated hemolysis on the basis of independent 86Rb and hemoglobin release.

1980 • 28 citations

Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. II. Electrolyte permeability increase in the target cell membrane concomitant with programming for lysis.

1976 • 26 citations

THE KINETICS OF ^51,Cr RELEASE FROM TARGET CELLS IN CELL MEDIATED CYTOTOXICITY AND THE RELATIONSHIP TO THE KINETICS OF KILLING

1975 • 25 citations

A comparison of antibody-dependent cellular cytotoxicity (ADCC) mediated by murine and human lymphoid cell populations

1977 • 25 citations

Susceptibility of Tumor Cells in Different Phases of the Mitotic Cycle to the Effect of Immune Lymphocytes

1974 • 25 citations

Characteristics of the effector cells mediating cytotoxicity against antibody-coated target cells. III. Ultrastructural studies.

1976 • 24 citations

THE UPTAKE AND RETENTION OF CHROMIUM BY CELLS

1976 • 24 citations

Mechanism of T cell-mediated cytolysis: the differential impact of cytochalasins at the recognition and lethal hit stages

1978 • 24 citations

Kinetic Analysis of Target Cell Destruction by Effector T Cells

1977 • 23 citations

Lymphocyte emperipolesis revisited. II. Further characterization of the lymphocyte subpopulation involved.

1979 • 23 citations

Non-T Cell-Mediated Cytolysis of Antibody-Coated Sheep Red Blood Cells Requires Mg++ but Not Ca++: An Argument against a Conventional “Stimulus-Secretion” Mechanism for Cytolysis

1975 • 22 citations

The mechanism of T cell mediated cytotoxicity III. Changes in target cell susceptibility during the cell cycle

1976 • 22 citations

Antibody-Dependent Cytolytically Active Human Leukocytes: An Analysis of Inactivation Following in Vitro Interaction with Antibody-Coated Target Cells

1975 • 22 citations

Kinetic Analysis of Target Cell Destruction by Effector T Cells. II. Changes in Killer Cell Avidity As a Function of Time and Antigen Dose

1979 • 22 citations

Early Steps in Specific Tumor Cell Lysis by Sensitized Mouse T Lymphocytes

1979 • 22 citations

Early Steps in Specific Tumor Cell Lysis by Sensitized Mouse T Lymphocytes

1976 • 21 citations

Changes in phospholipid metabolism of a tumor target cell during a cell-mediated cytotoxic reaction

1971 • 21 citations

Role of hydrogen peroxide in the cytotoxic reaction of T lymphocytes.

1980 • 21 citations

Requirement for hexose, unrelated to energy provision, in T-cell-mediated cytolysis at the lethal hit stage.

1978 • 20 citations

The mechanism of K cell (antibody-dependent) cell mediated cytotoxicity II. Characteristics of the effector cell and morphological changes in the target cell

1977 • 20 citations

The effect of cytochalasin B on effector--target cell interaction. Quantitative and ultrastructural study.

1975 • 19 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. X. Enucleated cells as targets for cytotoxic attack.

1978 • 19 citations

The effects of micro-operations on the morphology, survival, and lysosomes of Chinese hamster fibroblasts

1965 • 19 citations

Inhibition of T cell-mediated cytolysis by 2-deoxy-D-glucose (2-DG): differential effect of 2-DG on effector cells isolated early or late after alloantigenic stimulation in vitro.

1979 • 19 citations

Sizes of isotopically labeled molecules released during lysis of tumor cells labeled with 51Cr and [14C]nicotinamide

1976 • 18 citations

A membrane permeability test for the detection of cell surface antigens.

1975 • 17 citations

The mechanism of K-cell (antibodydependent) mediated cytotoxicity: III. the ultrastructure of K cell projections and their possible role in target cell killing

1979 • 17 citations

Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. IV. Inhibition of programming for lysis by pharmacologic agents.

1980 • 16 citations

The mechanism of T cell mediated cytotoxicity IV. Studies on communicating junctions between cells in contact

1977 • 15 citations

Inhibition of T Cell-Mediated Cytolysis by 2-Deoxy-D-Glucose (2-DG): Differential Effect of 2-DG on Effector Cells Isolated Early or Late After Alloantigenic Stimulation in Vitro

1979 • 15 citations

The mechanism of T-cell mediated cytotoxicity. VIII. Zeiosis corresponds to irreversible phase (programming for lysis) in steps leading to lysis.

1981 • 13 citations

Studies on the Mechanism of Lymphocyte-Mediated Cytolysis

1978 • 13 citations

Antibody-Dependent, Cell-Mediated Cytotoxicity of Nucleated Mammalian Cells by Rat Eosinophils and Neutrophils

1982 • 12 citations

Recognition by Cytolytic T and K Cells: Identification in Both Systems of a Divalent Cation-Independent, Cytochalasin A-Sensitive Step

1978 • 11 citations

The mechanism of K cell (antibody-dependent) cell mediated cytotoxicity I. The release of different cell components

1977 • 11 citations

Lysis of enucleated tumor cells with allogeneic and syngeneic cytotoxic thymus‐derived lymphocytes

1979 • 9 citations

Continuous Cytotoxic T-Cell Lines

1980 • 9 citations

Studies on the physiological manifestations of cell-mediated cytotoxicity

1975 • 9 citations

A TECHNIQUE FOR LIVER TRANSPLANTATION IN THE INBRED MOUSE

1976 • 8 citations

A Study of Proteolysis as a Possible Mechanism for T‐Cell‐Mediated Target Cell Lysis

1975 • 8 citations

The differentiation of cytotoxic T lymphocytes in vitro

1976 • 8 citations

Cell-mediated lympholysis: A receptor-associated lytic mechanism

1978 • 7 citations

Observations on the antibody-dependent cytotoxic cell by scanning electron microscopy.

1975 • 7 citations

THE SURFACE MORPHOLOGY AND THE CELL CYCLE OF MASTOCYTOMA TARGET CELLS: NO APPARENT EFFECT ON CELL‐MEDIATED KILLING

1976 • 7 citations

T-lymphocyte-mediated cytolysis: contribution of intracellular components to target cell susceptibility.

1977 • 6 citations

Ultrastructural Aspects of the Adherence to Target Cells of in Vitro Differentiated Lymphocytes

1975 • 6 citations

Analysis of cytotoxic effector cell populations by kinetic and monolayer adsorption techniques.

1980 • 5 citations

The selective adherence of lymphoblasts to antigenic cell monolayers. A method for determining the specificity of lymphocytes proliferating in response to histocompatibility antigens

1980 • 4 citations

Hyperthermia and formaldehyde can dissociate the binding and killing activities of cytolytic T lymphocytes.

1979 • 3 citations

Chlorpromazine and Lidocaine Inhibit Antibody-Dependent Cell-Mediated Cytotoxicity but Not Erythrocyte Antibody Rosette Formation

1980 • 2 citations

The mechanism of T-cell mediated cytotoxicity. VII. Lysis of isolated cytoplasts and karyoplasts.

1979 • 2 citations