Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

2004 • 3,278 citations

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

2004 • 2,880 citations

Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

2004 • 2,358 citations

Genome-wide association study reveals genetic risk underlying Parkinson's disease

2009 • 1,863 citations

The substantia nigra of the human brain

1999 • 1,598 citations

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

2009 • 1,502 citations

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

2006 • 1,489 citations

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

2008 • 1,422 citations

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

2009 • 1,280 citations

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

2005 • 1,172 citations

The vacuolar (H+)-ATPases — nature's most versatile proton pumps

2002 • 1,163 citations

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

2012 • 1,134 citations

Small molecule modulation of Smoothened activity

2002 • 958 citations

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

2006 • 861 citations

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

2010 • 794 citations

Pathogenic Lysosomal Depletion in Parkinson's Disease

2010 • 745 citations

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

1998 • 630 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Microtubule-Based Transport Systems in Neurons: The Roles of Kinesins and Dyneins

2000 • 544 citations

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

2010 • 519 citations

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells

2009 • 486 citations

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

2002 • 484 citations

A functionally characterized test set of human induced pluripotent stem cells

2011 • 478 citations

Localization of a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, PARK6, on Human Chromosome 1p35-p36

2001 • 473 citations

Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

2010 • 422 citations

The Regulation and Physiology of Mitochondrial Proton Leak

2011 • 419 citations

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases

1993 • 415 citations

Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease

2009 • 410 citations

A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease

2007 • 389 citations

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

2010 • 362 citations

Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection

2005 • 362 citations

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

2011 • 358 citations

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV α-Synucleinopathy

2009 • 354 citations

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

2009 • 317 citations

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

2010 • 286 citations

Genetic Analysis of Pathways to Parkinson Disease

2010 • 267 citations

Autosomal dominant parkinsonism associated with variable synuclein and tau pathology

2004 • 262 citations

Novel PINK1 mutations in early-onset parkinsonism

2005 • 226 citations

Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

2011 • 226 citations

CD15, CD24, and CD29 Define a Surface Biomarker Code for Neural Lineage Differentiation of Stem Cells

2009 • 224 citations

Biochemical and pathological characterization of Lrrk2

2006 • 223 citations

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

2008 • 218 citations

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization

2010 • 214 citations

Leucine‐rich repeat kinase 2 phosphorylates brain tubulin‐beta isoforms and modulates microtubule stability – a point of convergence in Parkinsonian neurodegeneration?

2009 • 213 citations

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid

2010 • 209 citations

Clinical features ofLRRK2-associated Parkinson's disease in central Norway

2005 • 186 citations

Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons

2004 • 171 citations

Parkinson's disease: insights from pathways

2010 • 161 citations

Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities

2009 • 152 citations

Stem Cells and Drug Discovery: The Beginning of a New Era?

2008 • 146 citations

Clinical Spectrum of Homozygous and Heterozygous PINK1 Mutations in a Large German Family With Parkinson Disease

2006 • 136 citations

1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C

2007 • 134 citations

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

2010 • 122 citations

Mitochondrial Respiratory Dysfunction in Familiar Parkinsonism Associated with PINK1 Mutation

2008 • 109 citations

Pluripotent Stem Cells and Disease Modeling

2009 • 107 citations

Clinical Features of Parkinson Disease Patients With Homozygous Leucine-Rich Repeat Kinase 2 G2019S Mutations

2006 • 99 citations

The c‐Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK‐ERK and Akt‐independent mechanism

2004 • 93 citations

Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach

2011 • 77 citations

Bafilomycin A1 is a potassium ionophore that impairs mitochondrial functions

2007 • 68 citations

PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations

2004 • 66 citations

Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction

2009 • 54 citations

Genetic analysis of LRRK2 mutations in patients with Parkinson disease

2006 • 53 citations

Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations

2007 • 52 citations

Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria

2010 • 47 citations

Development of Histocompatible Primate‐Induced Pluripotent Stem Cells for Neural Transplantation

2011 • 45 citations

The curious case of phenocopies in families with genetic Parkinson's disease

2011 • 41 citations

Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis

2007 • 31 citations

Examining Braak's hypothesis by imaging Parkinson's disease

2010 • 27 citations

Clinical and demographic characteristics of PINK1 mutation carriers-A meta-analysis

2010 • 20 citations