Pluripotent Stem Cells and Disease Modeling

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

2006 • 24,853 citations

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

2007 • 2,650 citations

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

2009 • 2,290 citations

Disease-Specific Induced Pluripotent Stem Cells

2008 • 2,123 citations

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

2008 • 1,924 citations

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

2009 • 1,756 citations

Induced pluripotent stem cells from a spinal muscular atrophy patient

2008 • 1,419 citations

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

2003 • 1,076 citations

Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures

2009 • 1,011 citations

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

2009 • 851 citations

Marked differences in differentiation propensity among human embryonic stem cell lines

2008 • 806 citations

iPS cells produce viable mice through tetraploid complementation

2009 • 779 citations

Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model

2007 • 777 citations

Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells

2009 • 511 citations

iPS Cells Can Support Full-Term Development of Tetraploid Blastocyst-Complemented Embryos

2009 • 457 citations

Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells

2009 • 377 citations

Developmental Study of Fragile X Syndrome Using Human Embryonic Stem Cells Derived from Preimplantation Genetically Diagnosed Embryos

2007 • 277 citations

Modeling for Lesch‐Nyhan Disease by Gene Targeting in Human Embryonic Stem Cells

2004 • 196 citations

The Laminopathies: The Functional Architecture of the Nucleus and Its Contribution to Disease

2006 • 162 citations

Stem Cells and Drug Discovery: The Beginning of a New Era?

2008 • 146 citations