Local gene knockdown in the brain using viral-mediated RNA interference

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

1998 • 3,973 citations

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

2000 • 1,767 citations

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

1999 • 1,290 citations

RNA interference in adult mice

2002 • 1,060 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

siRNA-mediated gene silencing in vitro and in vivo

2002 • 880 citations

Conditional control of gene expression in the mouse

2001 • 774 citations

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B

2003 • 724 citations

Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic

1995 • 714 citations

The neurobiology of drug addiction

1997 • 564 citations

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA

2003 • 547 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

Heritable gene silencing in Drosophila using double-stranded RNA

2000 • 503 citations

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

1996 • 458 citations

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

1995 • 441 citations

Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2

1999 • 392 citations

Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal

2003 • 363 citations

The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism

1998 • 225 citations

Recombinant adeno-associated virus vector: use for transgene expression and anterograde tract tracing in the CNS

1998 • 219 citations

Novel Genomic cDNA Hybrids Produce Effective RNA Interference in Adult Drosophila

2002 • 215 citations

Studying Gene Function in Eukaryotes by Conditional Gene Inactivation

2002 • 202 citations

RNAi functions in cultured mammalian neurons

2002 • 173 citations

DISTRIBUTION OF TYROSINE HYDROXYLASE IN HUMAN AND ANIMAL BRAIN¹

1971 • 152 citations

The actions of amphetamine on neurotransmitters: a brief review.

1977 • 127 citations

Simultaneous inhibition of GSK3α and GSK3β using hairpin siRNA expression vectors

2003 • 106 citations

An Extensive 3′ Regulatory Region Controls Expression of Bmp5 in Specific Anatomical Structures of the Mouse Embryo

1998 • 90 citations

Insulators coupled to a minimal bidirectional tet cassette for tight regulation of rAAV-mediated gene transfer in the mammalian brain

2001 • 68 citations

Effects of MPTP on locomotor activity in mice

1990 • 59 citations

Functional Neuropathology in Parkinson's Disease

1997 • 50 citations

Turnover rate of tyrosine hydroxylase during Trans-synaptic induction.

1975 • 45 citations

Cellular localization of tyrosine hydroxylase mRNA and its regulation in the rat adrenal medulla and brain by in situ hybridization with an oligodeoxyribonucleotide probe

1987 • 39 citations

Deleted Work

1955 • 0 citations