Activation of Akt and eIF4E Survival Pathways by Rapamycin-Mediated Mammalian Target of Rapamycin Inhibition

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

Upstream and downstream of mTOR

2004 • 4,085 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

The tor pathway: a target for cancer therapy

2004 • 1,308 citations

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 • 1,101 citations

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

2001 • 981 citations

Dysregulation of the TSC-mTOR pathway in human disease

2004 • 952 citations

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

2004 • 951 citations

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

2004 • 945 citations

Regulation of cap-dependent translation by eIF4E inhibitory proteins

2005 • 944 citations

The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway

2004 • 889 citations

eIF-4E expression and its role in malignancies and metastases

2004 • 702 citations

Amino Acid and Insulin Signaling via the mTOR/p70 S6 Kinase Pathway

2001 • 529 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

Balancing Akt with S6K

2004 • 472 citations

Restraining PI3K: mTOR signalling goes back to the membrane

2004 • 360 citations

AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and c-myc Expression

2004 • 335 citations

Rapamycins: Mechanisms of Action and Cellular Resistance

2003 • 290 citations

eIF4E activity is regulated at multiple levels

1999 • 287 citations

Determinants of Rapamycin Sensitivity in Breast Cancer Cells

2004 • 282 citations

Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.

2002 • 235 citations

Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells.

1997 • 209 citations

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

1998 • 198 citations

Will mTOR inhibitors make it as cancer drugs?

2003 • 193 citations

Activation of the Mammalian Target of Rapamycin Pathway Acutely Inhibits Insulin Signaling to Akt and Glucose Transport in 3T3-L1 and Human Adipocytes

2004 • 177 citations

Phosphorylation of Eukaryotic Translation Initiation Factor 4E Is Critical for Growth

2002 • 175 citations

Lost in translation

2004 • 173 citations

PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers

1998 • 170 citations

Targeting the molecular target of rapamycin (mTOR)

2004 • 154 citations

Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells

1999 • 116 citations

Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1

2000 • 112 citations

The farnesyltransferase inhibitor lonafarnib induces growth arrest or apoptosis of human lung cancer cells without downregulation of Akt

2004 • 30 citations