Astrocyte-Associated Fibronectin Is Critical for Axonal Regeneration in Adult White Matter

Regeneration beyond the glial scar

2004 • 2,896 citations

Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.

1988 • 876 citations

Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS

2003 • 839 citations

Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro

1990 • 775 citations

Regeneration of adult axons in white matter tracts of the central nervous system

1997 • 747 citations

Neurite extension by peripheral and central nervous system neurons in response to substratum-bound fibronectin and laminin

1983 • 672 citations

Robust Regeneration of Adult Sensory Axons in Degenerating White Matter of the Adult Rat Spinal Cord

1999 • 608 citations

Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.

1999 • 561 citations

Nerve growth factor, laminin, and fibronectin promote neurite growth in human fetal sensory ganglia cultures

1982 • 541 citations

The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury

2003 • 531 citations

Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells

2002 • 474 citations

Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes

2000 • 472 citations

Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation:In VivoandIn VitroAnalysis of Inflammation-Induced Secondary Injury after CNS Trauma

1999 • 455 citations

Isolation and culture of adult rat hippocampal neurons

1997 • 447 citations

Retinal Ganglion Cells Do Not Extend Axons by Default

2002 • 429 citations

Glia are a unique substrate for the in vitro growth of central nervous system neurons

1984 • 425 citations

Laminin is produced by early rat astrocytes in primary culture.

1983 • 389 citations

N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro.

1988 • 326 citations

Fibronectin regulates calvarial osteoblast differentiation

1996 • 301 citations

Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth

1990 • 299 citations

Laminin-immunoreactive glia distinguish regenerative adult CNS systems from non-regenerative ones.

1985 • 298 citations

Oligodendrocytes arrest neurite growth by contact inhibition

1990 • 285 citations

Neuronal Matrix Metalloproteinase-2 Degrades and Inactivates a Neurite-Inhibiting Chondroitin Sulfate Proteoglycan

1998 • 271 citations

Studies on the Development and Behavior of the Dystrophic Growth Cone, the Hallmark of Regeneration Failure, in anIn VitroModel of the Glial Scar and after Spinal Cord Injury

2004 • 257 citations

Is astrocyte laminin involved in axon guidance in the mammalian CNS?

1988 • 215 citations

Immunocytochemical demonstration of early appearing astroglial structures that form boundaries and pathways along axon tracts in the fetal brain

1993 • 194 citations

Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing.

1993 • 191 citations

Glial Boundaries in the Developing Nervous System

1993 • 188 citations

Regulation of expression of fibronectin and its receptor, α5β1, during development and regeneration of peripheral nerve

1992 • 184 citations

Repulsive factors and axon regeneration in the CNS

2001 • 180 citations

Astroglial neurotrophic and neurite-promoting factors

1995 • 170 citations

Integrins in point contacts mediate cell spreading: factors that regulate integrin accumulation in point contacts vs. focal contacts.

1993 • 165 citations

Fibronectin-like immunoreactivity in the developing cerebral cortex

1987 • 162 citations

Adult Neuronal Regeneration Induced by Transgenic Integrin Expression

2001 • 158 citations

Neurotrophic factor gene expression in astrocytes during development and following injury

1994 • 155 citations

Astrocytes in culture synthesize and secrete a variant form of fibronectin

1985 • 145 citations

Oligodendrocytes repel axons and cause axonal growth cone collapse

1989 • 128 citations

Neurons cultured from developing rat brain attach and spread preferentially to laminin

1984 • 128 citations

Fibronectin is expressed by astrocytes cultured from embryonic and early postnatal rat brain

1986 • 127 citations

Neuron-specific interactions with two neurite-promoting fragments of fibronectin

1985 • 123 citations

Long axon growth from embryonic neurons transplanted into myelinated tracts of the adult rat spinal cord

1993 • 116 citations

Secretion of Matrix Metalloproteinase-2 and -9 after Mechanical Trauma Injury in Rat Cortical Cultures and Involvement of MAP Kinase

2002 • 114 citations

Laminin overrides the inhibitory effects of peripheral nervous system and central nervous system myelin‐derived inhibitors of neurite growth

1995 • 114 citations

The Critical Role of Basement Membrane-Independent Laminin γ1 Chain during Axon Regeneration in the CNS

2002 • 104 citations

Transforming growth factor β1 and fibronectin messenger RNA in rat brain: Responses to injury and cell-type localization

1993 • 96 citations

Chapter 46 Central nervous system regeneration: oligodendrocytes and myelin as non-permissive substrates for neurite growth

1988 • 94 citations

Astroglia‐released neurite growth‐inducing activity for embryonic hippocampal neurons is associated with laminin bound in a sulfated complex and free fibronectin

1989 • 93 citations

Long interfascicular axon growth from embryonic neurons transplanted into adult myelinated tracts

1994 • 91 citations

Selective interaction of peripheral and central nervous system cells with two distinct cell-binding domains of fibronectin.

1987 • 82 citations

Alpha4 integrin is expressed during peripheral nerve regeneration and enhances neurite outgrowth.

2001 • 82 citations

Distinct roles for astrocyte αvβ5 and αvβ8 integrins in adhesion and migration

1999 • 81 citations

Axon outgrowth from grafts of human embryonic spinal cord in the lesioned adult rat spinal cord

1992 • 79 citations

Expression of neurotrophins in the adult spinal cord in vivo

1999 • 79 citations

Chondroitin Sulfate Proteoglycan and Tenascin in the Wounded Adult Mouse NeostriatumIn Vitro: Dopamine Neuron Attachment and Process Outgrowth

1996 • 77 citations

Long Fibre Growth by Axons of Embryonic Mouse Hippocampal Neurons Microtransplanted into the Adult Rat Fimbria

1993 • 76 citations

Directed nerve outgrowth is enhanced by engineered glial substrates

2003 • 75 citations

Role of Astroglial Extracellular Matrix in the Formation of Rat Olfactory Bulb Glomeruli

1993 • 73 citations

α4 Integrin Is Expressed during Peripheral Nerve Regeneration and Enhances Neurite Outgrowth

2001 • 70 citations

New roles for old proteins in adult CNS axonal regeneration

2003 • 65 citations

Myelin inhibitors: does NO mean GO?

2004 • 53 citations

Interaction with Heparin and Matrix Metalloproteinase 2 Cleavage Expose a Cryptic Anti-adhesive Site of Fibronectin

2000 • 53 citations

Connexin expression by alveolar epithelial cells is regulated by extracellular matrix

2001 • 53 citations

Molecular tunnels and boundaries for growing axons in the anterior commissure of hamster embryos

1998 • 47 citations

The Role of Fibronectin in Neural Development

1989 • 44 citations

Location of a fibronectin domain involved in newt epidermal cell migration.

1985 • 42 citations

Retinal neurite growth on astrocytes is not modified by extracellular matrix, anti‐L1 antibody, or oligodendrocytes

1991 • 41 citations

White Matter of the CNS Supports or Inhibits Neurite OutgrowthIn VitroDepending on Geometry

1999 • 40 citations

Reactive Astroglia Support Primary Dendritic but Not Axonal Outgrowth from Mouse Cortical Neuronsin Vitro

1996 • 36 citations

Evaluation of fibronectin gene expression by in situ hybridization. Differential expression of the fibronectin gene among populations of human alveolar macrophages.

1988 • 33 citations

Adenovirus-mediated Overexpression of C-terminal Src Kinase (Csk) in Type I Astrocytes Interferes with Cell Spreading and Attachment to Fibronectin

1999 • 33 citations

Keratan Sulfate Proteoglycan Phosphacan Regulates Mossy Fiber Outgrowth and Regeneration

2004 • 30 citations

Immunohistochemical expression of the alpha5 integrin subunit in the normal adult rat central nervous system.

2001 • 30 citations

Immunocytochemical localization of a cell adhesion molecule, integrin α5β1, in nerve growth cones

1999 • 29 citations

Age-dependent failure of axon regeneration in organotypic culture of gerbil auditory midbrain

1999 • 28 citations

Central and peripheral neurite outgrowth differs in preference for heparin-binding versus integrin-binding sequences

1992 • 27 citations

Independent regulation of primary dendritic and axonal growth by maturing astrocytes in vitro

1995 • 24 citations

Myelin‐Associated Inhibitors of Neurite Outgrowth and Their Role in CNS Regeneration

1991 • 24 citations

Axonal growth on astrocytes is not inhibited by oligodendrocytes

1992 • 23 citations

Myelin contributes to the parallel orientation of axonal growth on white matter in vitro.

2001 • 14 citations

Temporal and spatial regulation of chondroitin sulfate, radial glial cells, growing commissural axons, and other hippocampal efferents in developing hamsters

2003 • 11 citations

Deleted Work

1955 • 0 citations