Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Genetic progression model for head and neck cancer: implications for field cancerization.

1996 • 1,340 citations

Head and Neck Cancer

2001 • 1,258 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

1997 • 612 citations

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo

2000 • 594 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation

2001 • 507 citations

Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer.

1999 • 478 citations

Monoclonal antibodies to target epidermal growth factor receptor–positive tumors

2002 • 453 citations

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

2000 • 452 citations

Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer.

1993 • 420 citations

Notch signaling induces cell cycle arrest in small cell lung cancer cells.

2001 • 419 citations

STAT signaling in head and neck cancer

2000 • 374 citations

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

1986 • 370 citations

Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines

1993 • 367 citations

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3

1997 • 325 citations

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines

1996 • 318 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 312 citations

Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer.

2001 • 299 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

2001 • 263 citations

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.

1998 • 248 citations

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

1995 • 232 citations

Series Introduction: JAK-STAT signaling in human disease

2002 • 219 citations

Serine Phosphorylation and Negative Regulation of Stat3 by JNK

1999 • 219 citations

Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.

1997 • 189 citations

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

1997 • 155 citations

ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells

1999 • 122 citations

Epidermal Growth Factor Receptor–Mediated Stat3 Signaling Blocks Apoptosis in Head and Neck Cancer

2000 • 110 citations

Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines

2002 • 104 citations

MEN2A-RET-induced cellular transformation by activation of STAT3

2001 • 101 citations

Cytokine expression by head and neck squamous cell carcinomas

1992 • 99 citations

Oncogenes in head and neck cancer

1993 • 93 citations

Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines

1989 • 89 citations

Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens.

1998 • 88 citations

Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines

1999 • 85 citations

STAT3 activation is required for Asp816 mutant c-Kit induced tumorigenicity

2001 • 83 citations

Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.

1998 • 74 citations

A comparison of epidermal growth factor receptor (EGFR) and c-erbB-2 oncogene expression in head and neck squamous cell carcinomas

1991 • 59 citations

Altered expression and activity of G1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck

1997 • 49 citations

Cytokines that associate with the signal transducer gp130 activate the interferon-induced transcription factor p91 by tyrosine phosphorylation.

1994 • 38 citations

Potential Roles of Stat1 and Stat3 in Cellular Transformation

1999 • 34 citations

Epidermal growth factor receptor immunoreactivity in human laryngeal squamous cell carcinoma

1997 • 30 citations

Targeting growth factor receptors: integration of novel therapeutics in the management of head and neck cancer

2001 • 30 citations