Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells

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1988 • 7,933 citations

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

1993 • 1,395 citations

Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein

1993 • 720 citations

PDZ Domains: Structural Modules for Protein Complex Assembly

2002 • 696 citations

Isolation of a partial candidate gene for Menkes disease by positional cloning

1993 • 690 citations

Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.

1996 • 623 citations

Menkes's kinky hair syndrome. An inherited defect in copper absorption with widespread effects.

1972 • 550 citations

Regulation of tight junctions and loss of barrier function in pathophysiology

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The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium.

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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

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MENKES'S KINKY HAIR SYNDROME

1972 • 397 citations

Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site

1998 • 310 citations

Basolateral sorting in MDCK cells requires a distinct cytoplasmic domain determinant

1991 • 304 citations

A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells.

1994 • 253 citations

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes

1997 • 218 citations

The Menkes copper transporter is required for the activation of tyrosinase

2000 • 213 citations

Biochemical characterization and intracellular localization of the Menkes disease protein

1996 • 205 citations

Disorders of copper transport

1995 • 195 citations

Na,K-ATPase β-Subunit Is Required for Epithelial Polarization, Suppression of Invasion, and Cell Motility

2001 • 189 citations

Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux

1995 • 178 citations

Regulation and Function of the CD3γ DxxxLL Motif: A Binding Site for Adaptor Protein-1 and Adaptor Protein-2 in Vitro

1997 • 171 citations

The menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal

1999 • 168 citations

The Role of GMXCXXC Metal Binding Sites in the Copper-induced Redistribution of the Menkes Protein

1999 • 167 citations

Protein trafficking in the exocytic pathway of polarized epithelial cells

2001 • 153 citations

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network

1998 • 148 citations

Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines

2003 • 143 citations

Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus

2002 • 136 citations

Copper-regulated Trafficking of the Menkes Disease Copper ATPase Is Associated with Formation of a Phosphorylated Catalytic Intermediate

2002 • 134 citations

Functional Analysis of the N-terminal CXXC Metal-binding Motifs in the Human Menkes Copper-transporting P-type ATPase Expressed in Cultured Mammalian Cells

1999 • 127 citations

The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes.

1994 • 126 citations

A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)

2003 • 123 citations

Transport Protein Trafficking in Polarized Cells

2003 • 123 citations

Immunocytochemical Localization of the Menkes Copper Transport Protein (ATP7A) to the Trans-Golgi Network

1997 • 120 citations

Correction of the Copper Transport Defect of Menkes Patient Fibroblasts by Expression of the Menkes and Wilson ATPases

1998 • 114 citations

Medium Chains of Adaptor Complexes AP-1 and AP-2 Recognize Leucine-based Sorting Signals from the Invariant Chain

1998 • 104 citations

A Golgi localization signal identified in the Menkes recombinant protein

1998 • 94 citations

Copper-induced trafficking of the cU-ATPases: a key mechanism for copper homeostasis.

2003 • 91 citations

Apical Plasma Membrane Mispolarization of NaK-ATPase in Polycystic Kidney Disease Epithelia Is Associated with Aberrant Expression of the β2 Isoform

2000 • 90 citations

Distinct Reading of Different Structural Determinants Modulates the Dileucine-mediated Transport Steps of the Lysosomal Membrane Protein LIMPII and the Insulin-sensitive Glucose Transporter GLUT4

2000 • 87 citations

Identification of a di-leucine motif within the C terminus domain of the Menkes disease protein that mediates endocytosis from the plasma membrane

1999 • 84 citations

Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool

2004 • 82 citations

A mild form of Menkes steely hair syndrome

1981 • 78 citations

A spectroscopic method for assessing confluence of epithelial cell cultures

1991 • 73 citations

Menkes copper-translocating P-type ATPase (ATP7A): biochemical and cell biology properties, and role in Menkes disease.

2002 • 73 citations

Defective Copper-Induced Trafficking and Localization of the Menkes Protein in Patients With Mild and Copper-Treated Classical Menkes Disease

1999 • 68 citations

Regulated trafficking of the CFTR chloride channel

2000 • 66 citations

Polarized trafficking of plasma membrane proteins: emerging roles for coats, SNAREs, GTPases and their link to the cytoskeleton

1998 • 58 citations

Characterization of a Di-leucine–based Signal in the Cytoplasmic Tail of the Nucleotide-pyrophosphatase NPP1 That Mediates Basolateral Targeting but not Endocytosis

2001 • 55 citations

Isoforms of the Lutheran/Basal Cell Adhesion Molecule Glycoprotein Are Differentially Delivered in Polarized Epithelial Cells

1999 • 53 citations

Epithelial cell culture: A practical approach

1997 • 48 citations

Basolateral membrane expression of a K ⁺ channel, Kir 2.3, is directed by a cytoplasmic COOH-terminal domain

2001 • 47 citations

Basolateral sorting of transforming growth factor-α precursor in polarized epithelial cells: characterization of cytoplasmic domain determinants

2003 • 44 citations

The type 3 inositol 1,4,5-trisphosphate receptor is concentrated at the tight junction level in polarized MDCK cells

2003 • 43 citations

Intracellular traffic of the ecto-nucleotide pyrophosphatase/phosphodiesterase NPP3 to the apical plasma membrane of MDCK and Caco-2 cells: apical targeting occurs in the absence of N-glycosylation

2000 • 42 citations

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase

2003 • 34 citations

Mutational analysis of the Menkes copper P-type ATPase (ATP7A)

2003 • 24 citations

Genes regulating copper metabolism

1998 • 15 citations

Assessment of cell polarity

1996 • 11 citations