Retinoid receptors in vertebrate limb development

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Retinoic Acid Embryopathy

1985 • 1,921 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

An analysis of the syndrome of malformations induced by maternal vitamin a deficiency. Effects of restoration of vitamin a at various times during gestation

1953 • 754 citations

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

1991 • 730 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 • 672 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

Transport and Storage of Vitamin A

1990 • 618 citations

A new retinoic acid receptor identified from a hepatocellular carcinoma

1988 • 613 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Retinoic acid receptors and cellular retinoid binding proteins: I. A systematic study of their differential pattern of transcription during mouse organogenesis

1990 • 587 citations

Retinoic acid receptors and cellular retinoid binding proteins : II. Their differential pattern of transcription during early morphogenesis in mouse embryos

1991 • 527 citations

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

1990 • 524 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse

1989 • 482 citations

Vitamin A metabolism: new perspectives on absorption, transport, and storage

1991 • 433 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

Teratogens and craniofacial malformations: relationships to cell death

1988 • 397 citations

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

1991 • 395 citations

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

1991 • 394 citations

Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.

1991 • 390 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

A quantitative analysis of the effect of excision of the AER from the chick limb-bud

1974 • 376 citations

Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis.

1989 • 373 citations

Vitamin A congeners

1986 • 369 citations

Major Problems in Developmental Biology

1966 • 364 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells.

1991 • 328 citations

Homeobox gene expression correlated with the bifurcation process of limb cartilage development

1991 • 317 citations

Cellular Retinoid-Binding Proteins

1987 • 312 citations

H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

1989 • 306 citations

Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.

1990 • 304 citations

Cellular death in morphogenesis of the avian wing

1962 • 298 citations

Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells

1991 • 291 citations

Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid

1973 • 287 citations

Developmental analysis of the retinoic acid-inducible RAR-βJ2 promoter in transgenic animals

1991 • 258 citations

The development of the vertebrate limb

1980 • 254 citations

Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud

1990 • 252 citations

Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

1991 • 242 citations

Spatial distribution of cellular protein binding to retinoic acid in the chick limb bud

1988 • 241 citations

A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter.

1991 • 240 citations

A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter

1990 • 235 citations

TERATOGENIC ACTIVITY OF RETINOIC ACID

1967 • 233 citations

Cell Death in Morphogenesis

1966 • 232 citations

Experiments on the development in vitro of the avian knee-joint

1934 • 231 citations

Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development

1991 • 223 citations

A staging system for mouse limb development

1989 • 221 citations

Retinoic acid modifies mesodermal patterning in early Xenopus embryos.

1991 • 221 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein.

1990 • 212 citations

Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.

1991 • 212 citations

The effect of local application of retinoic acid to the anterior margin of the developing chick limb

1983 • 210 citations

Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium.

1982 • 202 citations

Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis

1992 • 201 citations

Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid.

1990 • 199 citations

Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine.

1988 • 188 citations

Position-dependent expression of two related homeobox genes in developing vertebrate limbs

1991 • 181 citations

Acyl-CoA-independent esterification of retinol bound to cellular retinol-binding protein (type II) by microsomes from rat small intestine.

1987 • 173 citations

Transfer of retinoic acid from its complex with cellular retinoic acid-binding protein to the nucleus

1986 • 171 citations

Isotretinoin embryopathy and the cranial neural crest: an in vivo and in vitro study.

1986 • 170 citations

Retinoids in Normal Development and Teratogenesis

1992 • 170 citations

A novel retinol-binding protein from rat. Purification and partial characterization.

1984 • 170 citations

Esterification of retinol in rat liver. Possible participation by cellular retinol-binding protein and cellular retinol-binding protein II.

1988 • 164 citations

Isolation of cDNA clones specific for collagen IV and laminin from mouse teratocarcinoma cells.

1983 • 163 citations

A member of the RXR nuclear receptor family is expressed in neural-crest-derived cells of the developing chick peripheral nervous system

1991 • 163 citations

Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo.

1990 • 162 citations

Limb Morphogenesis

1961 • 154 citations

The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element.

1991 • 152 citations

The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.

1991 • 152 citations

Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A.

1972 • 146 citations

Retinoic‐acid‐induced limb‐reduction defects: Perturbation of zones of programmed cell death as a pathogenetic mechanism

1989 • 135 citations

Temporal and regional differences in the expression pattern of distinct retinoic acid receptor-β transcripts in the chick embryo

1991 • 131 citations

Localization of specific retinoid-binding sites and expression of cellular retinoic-acid-binding protein (CRABP) in the early mouse embryo

1990 • 128 citations

Mouse cellular retinoic acid binding protein: cloning, complementary DNA sequence, and messenger RNA expression during the retinoic acid-induced differentiation of F9 wild type and RA-3-10 mutant teratocarcinoma cells.

1989 • 122 citations

Chicken homeobox gene Msx-1: structure, expression in limb buds and effect of retinoic acid

1991 • 120 citations

The expression of murine Hox-2 genes id dependent on the differenation pathway and displays a collinear sensitivity to retinoic acid in F9 cels andXenopusembroys

1991 • 119 citations

RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon.

1992 • 115 citations

Cellular retinol-binding protein allows specific interaction of retinol with the nucleus in vitro.

1979 • 115 citations

Modulation of chondrogenesis by the cytoskeleton and extracellular matrix

1991 • 113 citations

Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development

1991 • 108 citations

The primary structure of rat liver cellular retinol-binding protein.

1985 • 107 citations

Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue.

1990 • 106 citations

Purification and partial characterization of a novel binding protein for retinoic acid from neonatal rat.

1988 • 106 citations

A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos

1988 • 105 citations

Interaction between the proximo-distal and antero-posterior co-ordinates of positional value during the specification of positional information in the early development of the chick limb-bud

1974 • 99 citations

Interaction between limb bud ectoderm and mesoderm in the chick embryo. II. Experimental limb duplication

1956 • 96 citations

Isolation of cDNA clones for basal lamina components: type IV procollagen

1983 • 93 citations

Altered expression of the chicken homeobox-containing genes GHox-7 and GHox-8 in the limb buds of limbless mutant chick embryos

1991 • 91 citations

Antagonism between Retinoic Acid Receptors

1991 • 91 citations

Comparison of the tissue-specific expression and developmental regulation of two closely linked rodent genes encoding cytosolic retinol-binding proteins.

1987 • 86 citations

Regulation of the Cellular Retinoid-Binding Proteins and Their Messenger Ribonucleic Acids during P19 Embryonal Carcinoma Cell Differentiation Induced by Retinoic Acid

1989 • 81 citations

Interactions of ectoderm and mesoderm in the origin of axial relationships in the wing of the fowl

1958 • 78 citations

Molecular approaches to vertebrate limb morphogenesis

1989 • 75 citations

Cell death in the ‘opaque patch’ in the central mesenchyme of the developing chick limb: a cytological, cytochemical and electron microscopic analysis

1971 • 74 citations

Activity of the β-retinoic acid receptor promoter in transgenic mice

1991 • 74 citations

The development of the vertebrate limb : an approach through experiment, genetics, and evolution

1980 • 68 citations

Antagonism between retinoic acid receptors.

1991 • 55 citations

Retinoic acid promotes proliferation and chondrogenesis in the distal mesodermal cells of chick limb bud

1988 • 54 citations

Cellular retinoid binding proteins

1985 • 49 citations

Hereditary and induced modifications of the normal necrotic patterns in the developing limb buds of the rat and mouse: facts and hypotheses

1983 • 48 citations

Views of limb development and regeneration

1986 • 46 citations

Differential expression of two MSH-related homeobox genes Chox-7 and Chox-8 during chick limb development

1992 • 42 citations

Differentiation of cartilage and bone

1989 • 39 citations

Isolation of potential vertebrate limb-identity genes.

1989 • 36 citations

Limb Development and Deformity

1970 • 20 citations

Deleted Work

1955 • 0 citations