The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

Identification of common molecular subsequences

1981 • 9,753 citations

Multiple sequence alignment with Clustal X

1998 • 2,667 citations

PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization

1999 • 2,159 citations

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

1999 • 1,661 citations

Clinical and Genetic Abnormalities in Patients with Friedreich's Ataxia

1996 • 1,038 citations

Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin

1997 • 914 citations

Frataxin is Reduced in Friedreich Ataxia Patients and is Associated with Mitochondrial Membranes

1997 • 716 citations

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

2001 • 714 citations

Genome phylogeny based on gene content

1999 • 714 citations

The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins

1999 • 686 citations

Assembly of Iron-Sulfur Clusters

1998 • 632 citations

Predicting Protein Function by Genomic Context: Quantitative Evaluation and Qualitative Inferences

2000 • 506 citations

Measuring genome evolution

1998 • 449 citations

IscU as a Scaffold for Iron−Sulfur Cluster Biosynthesis: Sequential Assembly of [2Fe-2S] and [4Fe-4S] Clusters in IscU

2000 • 420 citations

Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria

1997 • 384 citations

Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue

1997 • 344 citations

Maturation of cellular Fe-S proteins: an essential function of mitochondria

2000 • 308 citations

A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates.

1996 • 304 citations

Its substrate specificity characterizes the DnaJ co-chaperone as a scanning factor for the DnaK chaperone

2001 • 301 citations

The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli

2000 • 292 citations

Lineage-specific loss and divergence of functionally linked genes in eukaryotes

2000 • 291 citations

Evidence for a conserved system for iron metabolism in the mitochondria of Saccharomyces cerevisiae

1999 • 286 citations

A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins

2000 • 269 citations

Iron-Dependent Self-Assembly of Recombinant Yeast Frataxin: Implications for Friedreich Ataxia

2000 • 246 citations

Functional Assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-0RF3 Gene Cluster Involved in the Assembly of Fe-S Clusters in Escherichia coli

1999 • 238 citations

Interaction of the iron–sulfur cluster assembly protein IscU with the Hsc66/Hsc20 molecular chaperone system of Escherichia coli

2000 • 209 citations

Iron-Sulfur Cluster Assembly

2001 • 201 citations

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells

2000 • 191 citations

Role of Saccharomyces cerevisiae ISA1and ISA2 in Iron Homeostasis

2000 • 168 citations

Towards a structural understanding of Friedreich’s ataxia: the solution structure of frataxin

2000 • 162 citations

Friedreich's ataxia protein: phylogenetic evidence for mitochondrial dysfunction

1996 • 156 citations

Structure-Function Analysis of the Zinc Finger Region of the DnaJ Molecular Chaperone

1996 • 150 citations

Recent advances in the molecular pathogenesis of Friedreich ataxia

2000 • 148 citations

Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain

1999 • 147 citations

Jac1, a mitochondrial J-type chaperone, is involved in the biogenesis of Fe/S clusters in Saccharomyces cerevisiae

2001 • 127 citations

The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria11Edited by B. Holland

2001 • 126 citations

Isa1p Is a Component of the Mitochondrial Machinery for Maturation of Cellular Iron-Sulfur Proteins and Requires Conserved Cysteine Residues for Function

2000 • 122 citations

Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family

2000 • 119 citations

The Fe/S Assembly Protein IscU Behaves as a Substrate for the Molecular Chaperone Hsc66 from Escherichia coli

2001 • 113 citations

Role of the Mitochondrial Hsp70s, Ssc1 and Ssq1, in the Maturation of Yfh1

2000 • 81 citations

Gene and context: Integrative approaches to genome analysis

2000 • 75 citations

Crystal Structure of Hsc20, a J-type Co-chaperone from Escherichia coli

2000 • 60 citations

ARH1 ofSaccharomyces cerevisiae: A new essential gene that codes for a protein homologous to the human adrenodoxin reductase

1998 • 58 citations

Modularity in the gain and loss of genes: applications for function prediction

2001 • 49 citations