Skin‐derived fibroblasts from long‐lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone

Free radicals in biology and medicine

1991 • 17,840 citations

Phylogenies and the Comparative Method

1985 • 9,661 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Oxidative mechanisms in the toxicity of metal ions

1995 • 4,127 citations

TESTING FOR PHYLOGENETIC SIGNAL IN COMPARATIVE DATA: BEHAVIORAL TRAITS ARE MORE LABILE

2003 • 3,915 citations

Phylogenetic Analysis and Comparative Data: A Test and Review of Evidence

2002 • 2,474 citations

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

Procedures for the Analysis of Comparative Data Using Phylogenetically Independent Contrasts

1992 • 2,193 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Phylogenetic Analysis of Covariance by Computer Simulation

1993 • 1,225 citations

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

2003 • 1,056 citations

Using the Past to Predict the Present: Confidence Intervals for Regression Equations in Phylogenetic Comparative Methods

2000 • 819 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Phylogenetic approaches in comparative physiology

2005 • 688 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

2000 • 613 citations

An Introduction to Phylogenetically Based Statistical Methods, with a New Method for Confidence Intervals on Ancestral Values

1999 • 596 citations

Phylogeny and Divergence-Date Estimates of Rapid Radiations in Muroid Rodents Based on Multiple Nuclear Genes

2004 • 546 citations

The Biology of Senescence

1978 • 539 citations

Mammalian Aging, Metabolism, and Ecology: Evidence From the Bats and Marsupials

1991 • 450 citations

Handbook of the Biology of Aging

2005 • 413 citations

Life history, ecology and longevity in bats

2002 • 410 citations

A method for testing the assumption of phylogenetic independence in comparative data

1999 • 409 citations

Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.

1980 • 385 citations

The Biochemical and Cellular Basis of Cell Proliferation Assays That Use Tetrazolium Salts

1996 • 376 citations

Positive correlation between mammalian life span and cellular resistance to stress

1999 • 330 citations

Phylogeny of muroid rodents: relationships within and among major lineages as determined by IRBP gene sequences

2003 • 284 citations

A mechanism of paraquat toxicity in mice and rats

1976 • 253 citations

Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress

2005 • 248 citations

Longer Life Spans and Delayed Maturation in Wild-Derived Mice

2002 • 247 citations

The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation

1990 • 218 citations

Multiplex stress resistance in cells from long‐lived dwarf mice

2003 • 213 citations

Thermotolerance of a Long-lived Mutant of Caenorhabditis elegans

1994 • 208 citations

Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture

2003 • 202 citations

Nuclear DNA phylogeny of the squirrels (Mammalia: Rodentia) and the evolution of arboreality from c-myc and RAG1

2003 • 202 citations

A new phylogenetic marker, apolipoprotein B, provides compelling evidence for eutherian relationships

2003 • 198 citations

Genes That Prolong Life: Relationships of Growth Hormone and Growth to Aging and Life Span

2001 • 182 citations

Relationship between antioxidant defenses and longevity in different mammalian species

1990 • 175 citations

HAGR: the Human Ageing Genomic Resources

2004 • 168 citations

Higher-level systematics of rodents and divergence time estimates based on two congruent nuclear genes

2003 • 152 citations

Molecular Systematics of Sciurognathi (Rodentia): The Mitochondrial Cytochrome b and 12S rRNA Genes Support the Anomaluroidea (Pedetidae and Anomaluridae)

2002 • 148 citations

Multigene phylogeny of the Old World mice, Murinae, reveals distinct geographic lineages and the declining utility of mitochondrial genes compared to nuclear genes

2005 • 145 citations

Hypothesis: Interventions That Increase the Response to Stress Offer the Potential for Effective Life Prolongation and Increased Health

1996 • 132 citations

Correlations between physiology and lifespan – two widely ignored problems with comparative studies

2005 • 123 citations

There is substantial agreement among interspecies estimates of DNA repair activity

1996 • 120 citations

Phylogenetic Relationships in the Genus Mus, Based on Paternally, Maternally, and Biparentally Inherited Characters

2002 • 119 citations

Longevity Records: Life spans of Mammals, Birds, Reptiles, Amphibians and Fish

2000 • 118 citations

Exceptional Cellular Resistance to Oxidative Damage in Long-Lived Birds Requires Active Gene Expression

2001 • 110 citations

Cell surface oxygen consumption by mitochondrial gene knockout cells

2004 • 109 citations

The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals

1981 • 99 citations

Longevity Records: Life Spans of Mammals, Birds, Amphibians, Reptiles, and Fish

2008 • 97 citations

Cultured Renal Epithelial Cells From Birds and Mice: Enhanced Resistance of Avian Cells to Oxidative Stress and DNA Damage

1998 • 96 citations

Absence of correlation between DNA repair in ultraviolet irradiated mammalian cells and life span of the donor species.

1980 • 95 citations

Phylogeny of Rodentia (Mammalia) Inferred from the Nuclear-Encoded Gene IRBP

2001 • 88 citations

Diverse aging rates in metazoans: targets for functional genomics

2004 • 88 citations

Revisiting the rodent repairadox

2001 • 82 citations

Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span

1984 • 81 citations

Discussion

1999 • 72 citations

DNA repair and longevity in three species of cold-blooded vertebrates

1980 • 66 citations

Mouse (Mus musculus) stocks derived from tropical islands: new models for genetic analysis of life‐history traits

2000 • 52 citations

Fibroblasts from long‐lived Snell dwarf mice are resistant to oxygen‐induced in vitro growth arrest

2006 • 47 citations

Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice

2006 • 42 citations

NUCLEAR INTRON SEQUENCES FOR PHYLOGENETICS OF CLOSELY RELATED MAMMALS: AN EXAMPLE USING THE PHYLOGENY OFMUS

2001 • 39 citations

Growth and Aging

2005 • 30 citations

Biomarkers of aging.

1990 • 1 citations