T Cell Responses to Mycobacterial Catalase-Peroxidase Profile a Pathogenic Antigen in Systemic Sarcoidosis

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999

1999 • 1,976 citations

Statement on Sarcoidosis

1999 • 1,776 citations

Clinical Characteristics of Patients in a Case Control Study of Sarcoidosis

2001 • 1,647 citations

The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis

1992 • 1,287 citations

Induction and effector functions of TH17 cells

2008 • 1,197 citations

Pulmonary sarcoidosis

2018 • 894 citations

T CELL MEMORY

1998 • 863 citations

Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis.

1985 • 462 citations

Understanding the generation and function of memory T cell subsets

2005 • 459 citations

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

2000 • 448 citations

The immune paradox of sarcoidosis and regulatory T cells

2006 • 433 citations

Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells

2001 • 406 citations

Mycobacterial catalase–peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis

2005 • 371 citations

Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis-Infected Individuals: Associations with Clinical Disease State and Effect of Treatment

2001 • 355 citations

Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis.

1996 • 331 citations

The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis.

1987 • 318 citations

Restraining mycobacteria: Role of granulomas in mycobacterial infections

2000 • 303 citations

Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells

1987 • 287 citations

Targeted tuberculin testing and treatment of latent tuberculosis infection. American Thoracic Society.

2000 • 280 citations

Sarcoidosis: TNF- α Release from Alveolar Macrophages and Serum Level of sIL-2R Are Prognostic Markers

1997 • 231 citations

Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis

2007 • 222 citations

Temporal and Spatial Arrangement of Lymphocytes within Lung Granulomas Induced by Aerosol Infection withMycobacterium tuberculosis

2001 • 218 citations

Cytokine patterns in tuberculous and sarcoid granulomas: correlations with histopathologic features of the granulomatous response.

1997 • 200 citations

Superinfecting mycobacteria home to established tuberculous granulomas

2004 • 177 citations

ETIOLOGY OF SARCOIDOSIS

1997 • 175 citations

Sex-Specific Manifestations of Löfgren's Syndrome

2006 • 163 citations

Cell damage and autoimmunity: A critical appraisal

2008 • 160 citations

Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis

2006 • 157 citations

Bias toward use of a specific T cell receptor beta-chain variable region in a subgroup of individuals with sarcoidosis.

1988 • 156 citations

Overexpression, Purification, and Characterization of the Catalase-peroxidase KatG from Mycobacterium tuberculosis

1997 • 154 citations

In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis.

1983 • 151 citations

Restricted Vα2.3 gene usage by CD4+ T lymphocytes in bronchoalveolar lavage fluid from sarcoidosis patients correlates with HLA-DR3

1992 • 150 citations

Epidemiology of Sarcoidosis: Recent Advances and Future Prospects

2007 • 148 citations

Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo.

1999 • 140 citations

The role of infection in the pathogenesis of autoimmune disease

1998 • 134 citations

Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis.

1997 • 133 citations

Comparison of Antigen‐Specific T‐Cell Responses of Tuberculosis Patients using Complex or Single Antigens of Mycobacterium tuberculosis

1998 • 132 citations

Etiology of Sarcoidosis

2008 • 131 citations

T-cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients.

1994 • 129 citations

Protective Immunity againstMycobacterium tuberculosisInduced by Dendritic Cells Pulsed with both CD8⁺- and CD4⁺-T-Cell Epitopes from Antigen 85A

2002 • 124 citations

Relationship between changed alveolar-capillary permeability and angiotensin converting enzyme activity in serum in sarcoidosis.

1986 • 119 citations

Identification of HLA-DR–bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis

2007 • 119 citations

Antibodies to the IL-12 Receptor β2 Chain Mark Human Th1 But Not Th2 Cells In Vitro and In Vivo

1999 • 115 citations

Sarcoid-like Pulmonary Disorder in Human Immunodeficiency Virus–infected Patients Receiving Antiretroviral Therapy

1999 • 113 citations

Evolution of Epitope-Specific Memory CD4+ T Cells After Clearance of Hepatitis C Virus

2002 • 111 citations

Selective activation and accumulation of oligoclonal V beta-specific T cells in active pulmonary sarcoidosis.

1994 • 110 citations

T cell memory. Long-term persistence of virus-specific cytotoxic T cells.

1989 • 109 citations

Sarcoidosis-Immunopathogenetic Concepts

2007 • 108 citations

Role of IL-18 in CD4+ T Lymphocyte Activation in Sarcoidosis

2000 • 103 citations

Target organ localization of memory CD4+ T cells in patients with chronic beryllium disease

2002 • 94 citations

Tuberculosis in patients with various HLA phenotypes

1990 • 91 citations

CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

2007 • 85 citations

Expression of Th1 markers by lung accumulated T cells in pulmonary sarcoidosis

2003 • 84 citations

Cytokine–Chemokine Networks in Experimental Mycobacterial and Schistosomal Pulmonary Granuloma Formation

2003 • 82 citations

Target organ localization of memory CD4+ T cells in patients with chronic beryllium disease

2002 • 81 citations

Lung T-Helper Cells Expressing T-cell Receptor AV2S3 Associate with Clinical Features of Pulmonary Sarcoidosis

2000 • 79 citations

Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis

2008 • 77 citations

GENETICS OF SARCOIDOSIS

1997 • 75 citations

Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis

2006 • 74 citations

TCR expression of activated T cell clones in the lungs of patients with pulmonary sarcoidosis.

1994 • 73 citations

Recurrence of Sarcoidosis Following Interferon Alpha Therapy for Chronic Hepatitis C.

1996 • 68 citations

Mycobacterium tuberculosis Antigen 85A Induces Th-1 Immune Responses in Systemic Sarcoidosis

2007 • 63 citations

Restricted Usage of T Cell Receptor Vα/Jα Gene Segments with Different Nucleotide but Identical Amino Acid Sequences in HLA-DR3+ Sarcoidosis Patients

1995 • 62 citations

Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response

2005 • 61 citations

Mycobacterial heat shock protein‐induced blood T lymphocytes subsets and cytokine pattern: Comparison of sarcoidosis with tuberculosis and healthy controls

2007 • 61 citations

Unique T Cell Effector Functions Elicited by Plasmodium falciparum Epitopes in Malaria-Exposed Africans Tested by Three T Cell Assays

2001 • 59 citations

Persistent Cytomegalovirus-Specific Memory Responses in the Lung Allograft and Blood following Primary Infection in Lung Transplant Recipients

2006 • 58 citations

Lymphocyte Recruitment and Protective Efficacy against Pulmonary Mycobacterial Infection Are Independent of the Route of PriorMycobacterium bovisBCG Immunization

2002 • 53 citations

The role of mycobacteria in the pathogenesis of sarcoidosis.

1998 • 53 citations

Genetics of Sarcoidosis

2007 • 47 citations

Limited heterogeneity of biased T‐cell receptor Vβ gene usage in lung but not blood T cells in active pulmonary sarcoidosis

1996 • 42 citations

Recruitment of Antigen-Specific Th1-Like Responses to the Human Lung following Bronchoscopic Segmental Challenge with Purified Protein Derivative of Mycobacterium tuberculosis

2003 • 37 citations

CD4 T–cell memory can persist in the absence of class II

2000 • 36 citations

Antigen-induced Proliferative Response of Lavage and Blood T Lymphocytes: Comparison of Cells from Normal Subjects and Patients with Sarcoidosis

1991 • 36 citations

Strain variation in the katG region of Mycobacterium tuberculosis

1994 • 36 citations

Flow Cytometry Analysis Using the Becton Dickinson <scp>FACS</scp> Calibur

2002 • 35 citations

Involvement of T cells and alterations in T cell receptors in sarcoidosis.

1998 • 34 citations

Expression of surface antigens distinguishing "naive" and previously activated lymphocytes in bronchoalveolar lavage fluid.

1990 • 31 citations

In Vitro Expansion of T-Cell-Receptor Vα2.3⁺CD4⁺T Lymphocytes in HLA-DR17(3), DQ2⁺Individuals upon Stimulation withMycobacterium tuberculosis

1999 • 19 citations

Increased CD45RO expression on T lymphocytes in mediastinal lymph node and pulmonary lesions of patients with pulmonary sarcoidosis

1994 • 17 citations

Expression and immune recognition of stress proteins in sarcoidosis and other chronic interstitial lung diseases

1995 • 15 citations

Consensus conference: activity of sarcoidosis. Third WASOG meeting, Los Angeles, USA, September 8-11, 1993.

1994 • 10 citations

Analysis of Responses of Peripheral Blood Lymphocytes From Sarcoidosis Patients to Purified Protein Derivative

2000 • 4 citations