Role of the actin cytoskeleton in insulin action

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

The insulin signaling system.

1994 • 1,733 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.

1996 • 769 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

After Insulin Binds

1987 • 687 citations

Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein

1988 • 661 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts

1999 • 590 citations

Latrunculins—novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D

1989 • 566 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Signaling Mechanisms That Regulate Glucose Transport

1999 • 525 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Botulinum C2 toxin ADP-ribosylates actin

1986 • 503 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 358 citations

Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

1998 • 336 citations

Mechanism of insulin action on glucose transport in the isolated rat adipose cell. Enhancement of the number of functional transport systems.

1978 • 330 citations

Facilitative glucose transporters: an expanding family

1990 • 316 citations

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

1993 • 308 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites

1994 • 297 citations

Regulation of gene expression by insulin

1991 • 278 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1992 • 263 citations

Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles

1998 • 242 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes.

1990 • 236 citations

Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells

1997 • 230 citations

Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.

1996 • 227 citations

Intracellular signalling: PDK1 – a kinase at the hub of things

1999 • 221 citations

GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay

1998 • 220 citations

Evidence for Involvement of Protein Kinase C (PKC)-ζ and Noninvolvement of Diacylglycerol-Sensitive PKCs in Insulin-Stimulated Glucose Transport in L6 Myotubes*

1997 • 218 citations

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

1998 • 206 citations

Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.

1994 • 204 citations

Differential Effects of PAK1-activating Mutations Reveal Activity-dependent and -independent Effects on Cytoskeletal Regulation

1998 • 201 citations

The Localization of Myosin VI at the Golgi Complex and Leading Edge of Fibroblasts and Its Phosphorylation and Recruitment into Membrane Ruffles of A431 Cells after Growth Factor Stimulation

1998 • 198 citations

Membrane ruffling and signal transduction

1994 • 183 citations

Focal adhesion kinase: an integrin-linked protein tyrosine kinase

1993 • 177 citations

Intracellular Localization of Phosphatidylinositide 3-kinase and Insulin Receptor Substrate-1 in Adipocytes: Potential Involvement of a Membrane Skeleton

1998 • 169 citations

The Thrombospondin Receptor CD47 (IAP) Modulates and Associates with α2β1 Integrin in Vascular Smooth Muscle Cells

1998 • 165 citations

Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

1998 • 155 citations

Insulin and okadaic acid induce Rab4 redistribution in adipocytes.

1993 • 154 citations

Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells

1991 • 148 citations

Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.

1995 • 146 citations

Requirement for Phosphoinositide 3-Kinase in Insulin-Stimulated GLUT4 Translocation in 3T3-L1 Adipocytes

1995 • 143 citations

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

1995 • 132 citations

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

1994 • 130 citations

Insulin-mediated Targeting of Phosphatidylinositol 3-Kinase to GLUT4-containing Vesicles

1996 • 129 citations

Akt-2 Binds to Glut4-containing Vesicles and Phosphorylates Their Component Proteins in Response to Insulin

1999 • 128 citations

Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase

1996 • 127 citations

Stimulation of phosphatidylinositol 3'-kinase association with foca adhesion kinase by platelet-derived growth factor.

1994 • 126 citations

The Pleckstrin Homology Domain in Insulin Receptor Substrate-1 Sensitizes Insulin Signaling

1995 • 113 citations

Tyrosine phosphatase inhibitors, vanadate and pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of phosphatidylinositol 3-kinase and protein kinase C.

1998 • 105 citations

Potential Role of Rab4 in the Regulation of Subcellular Localization of Glut4 in Adipocytes

1996 • 103 citations

Phosphatidylinositol 3-kinase binds to α-actinin through the p85 subunit

1994 • 92 citations

Rapid stimulation of glucose transport by mitochondrial uncoupling depends in part on cytosolic Ca²⁺ and cPKC

1998 • 87 citations

Heterogeneity in lymphocyte spectrin distribution: ultrastructural identification of a new spectrin-rich cytoplasmic structure.

1988 • 86 citations

Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction

1997 • 85 citations

Detection of the GLUT3 facilitative glucose transporter in rat L6 muscle cells: Regulation by cellular differentiation, insulin and insulin-like growth factor-I

1992 • 82 citations

Phosphoinositide 3-Kinase as an Upstream Regulator of the Small GTP-Binding Protein Rac in the Insulin Signaling of Membrane Ruffling

1995 • 78 citations

Insulin receptor internalization: molecular mechanisms and physiopathological implications

1994 • 76 citations

Insulin Stimulates the Tyrosine Dephosphorylation of pp125 Focal Adhesion Kinase

1995 • 74 citations

Divergent Insulin and Platelet-derived Growth Factor Regulation of Focal Adhesion Kinase (pp125FAK) Tyrosine Phosphorylation, and Rearrangement of Actin Stress Fibers

1995 • 74 citations

Actin Filaments Facilitate Insulin Activation of the Src and Collagen Homologous/Mitogen-activated Protein Kinase Pathway Leading to DNA Synthesis and c-fos Expression

1998 • 70 citations

Src Homologous and Collagen (Shc) Protein Binds to F-actin and Translocates to the Cytoskeleton upon Nerve Growth Factor Stimulation in PC12 Cells

1995 • 68 citations

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

1997 • 67 citations

Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with insulin action

1995 • 65 citations

A Synthetic Peptide Corresponding to the Rab4 Hypervariable Carboxyl-terminal Domain Inhibits Insulin Action on Glucose Transport in Rat Adipocytes

1996 • 63 citations

Insulin Receptor Substrate-1 as a Signaling Molecule for Focal Adhesion Kinase pp125FAK and pp60

1998 • 63 citations

Movement of axoplasmic organelles on actin filaments assembled on acrosomal processes: evidence for a barbed-end-directed organelle motor

1994 • 61 citations

Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor.

1996 • 60 citations

Involvement of phosphoinositide 3-kinase and Rac in membrane ruffling induced by IL-2 in T cells

1998 • 57 citations

Insulin Stimulates Guanine Nucleotide Exchange on Rab4 via a Wortmannin-sensitive Signaling Pathway in Rat Adipocytes

1997 • 56 citations

Synthesis and characterization of 19F NMR chelators for measurement of cytosolic free Ca

1987 • 55 citations

Insulin Stimulates the Phosphorylation of the 66- and 52-Kilodalton Shc Isoforms by Distinct Pathways¹

1997 • 55 citations

Insulin-induced egr-1 and c-fos Expression in 32D Cells Requires Insulin Receptor, Shc, and Mitogen-activated Protein Kinase, but Not Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Activation

1996 • 51 citations

Cytochalasin B: Effects on membrane ruffling, growth cone and microspike activity, and microfilament structure not due to altered glucose transport

1973 • 51 citations

The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes

1995 • 50 citations

Requirement for receptor-intrinsic tyrosine kinase activities during ligand-induced membrane ruffling of KB cells. Essential sites of src-related growth factor receptor kinases.

1988 • 48 citations

Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activation.

1996 • 34 citations

Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation.

1993 • 34 citations

Movement of axoplasmic organelles on actin filaments from skeletal muscle

1994 • 31 citations

Insulin‐responsive glucose transporters are concentrated in a cell surfacederived membrane fraction of 3T3‐L1 adipocytes

1990 • 30 citations

Interaction of Insulin Receptor Substrate-1 with the ς3A Subunit of the Adaptor Protein Complex-3 in Cultured Adipocytes

1998 • 25 citations

Opposite Effects of Insulin on Focal Adhesion Proteins in 3T3-L1 Adipocytes and in Cells Overexpressing the Insulin Receptor

1998 • 24 citations

Insulin receptor internalization and recycling: mechanism and significance

1985 • 24 citations

Heterologous expression of rab4 reduces glucose transport and GLUT4 abundance at the cell surface in oocytes

1997 • 21 citations

A three‐dimensional model of membrane ruffling from transmission and scanning electron microscopy of cultured monkey kidney cells (LLCMK₂)*

1972 • 21 citations

Insulin-Induced Circular Membrane Ruffling on Rat 1 Cells Expressing a High Number of Human Insulin Receptors: Circular Ruffles Caused by Rapid Actin Reorganization Exhibit High Density of Insulin Receptors and Phosphotyrosines

1993 • 20 citations

Restricted localization of the adipocyte/muscle glucose transporter species to a cell surface‐derived vesicle fraction of 3T3‐L1 adipocytes

1990 • 18 citations

Characterisation of spectrin isoforms associated with GLUT4

1997 • 5 citations

Intracellular localisation of βIΣ2 spectrin with GLUT4 vesicles

1998 • 2 citations