AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

Bone Marrow Transplant

1990 • 2,745 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 582 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 494 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 362 citations

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

1997 • 362 citations

Evidence for a multistep pathogenesis of chronic myelogenous leukemia

1981 • 331 citations

Clonal Development, Stem-Cell Differentiation, and Clinical Remissions in Acute Nonlymphocytic Leukemia

1987 • 319 citations

HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G ₀ /G ₁ human hematopoietic stem cells

1998 • 306 citations

Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission

1993 • 297 citations

Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation

1991 • 288 citations

The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

1998 • 280 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 280 citations

Acute nonlymphocytic leukemia: heterogeneity of stem cell origin

1981 • 259 citations

Acute nonlymphocytic leukemia: heterogeneity of stem cell origin

1981 • 215 citations

THE AML1‐ETO CHIMAERIC TRANSCRIPTION FACTOR IN ACUTE MYELOID LEUKAEMIA: BIOLOGY AND CLINICAL SIGNIFICANCE

1999 • 214 citations

Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia

1996 • 203 citations

The AML1/ETO fusion protein activates transcription of BCL-2

1996 • 191 citations

Measurement of Residual Leukemia during Remission in Childhood Acute Lymphoblastic Leukemia

1997 • 189 citations

Mice Defective in Two Apoptosis Pathways in the Myeloid Lineage Develop Acute Myeloblastic Leukemia

1998 • 173 citations

AML1/ETO fusion mRNA can be detected in remission blood samples of all patients with t(8;21) acute myeloid leukemia after chemotherapy or autologous bone marrow transplantation.

1994 • 156 citations

A simplified method for cryopreservation of peripheral blood stem cells at -80 degrees C without rate-controlled freezing.

1991 • 107 citations

Clonal remissions in acute nonlymphocytic leukemia: evidence for a multistep pathogenesis of the malignancy

1991 • 95 citations

Should Polymerase Chain Reaction Analysis to Detect Minimal Residual Disease in Patients With Chronic Myelogenous Leukemia Be Used in Clinical Decision Making?

1999 • 92 citations

Clonal Origin of Chronic Myelocytic Leukemia

1973 • 76 citations

Translocation (8;21)(q22;q22) in Acute Nonlymphocytic Leukemia

1984 • 75 citations

Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation.

1992 • 70 citations

Detection of minimal residual disease in acute myeloid leukaemia: methodologies, clinical and biological significance

1999 • 62 citations

Should Polymerase Chain Reaction Analysis to Detect Minimal Residual Disease in Patients With Chronic Myelogenous Leukemia Be Used in Clinical Decision Making?

1999 • 62 citations

The c-kit+ Maturation Pathway in Mouse Thymic T Cell Development: Lineages and Selection

1996 • 56 citations

Clonal analysis of bcr-abl rearrangement in T lymphocytes from patients with chronic myelogenous leukemia

1992 • 53 citations

Quantitative analysis of AML1/ET0 transcripts in peripheral blood stem cell harvests from patients with t(8;21) acute myelogenous leukaemia

1995 • 49 citations

Quantification of PML‐RARα transcripts in acute promyelocytic leukaemia: explanation for the lack of sensitivity of RT‐PCR for the detection of minimal residual disease and induction of the leukaemia‐specific mRNA by alpha interferon

1996 • 42 citations

Clonal analysis of bcr-abl rearrangement in T lymphocytes from patients with chronic myelogenous leukemia

1992 • 39 citations

Heterogeneity of B cell involvement in acute nonlymphocytic leukemia

1985 • 33 citations

T lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia.

1993 • 31 citations

Polyclonal haemopoieses associated with long‐term persistence of the AML1‐ETO transcript in patients with FAB M2 acute myeloid leukaemia in continous clinical remission

1995 • 26 citations

Granulocyte colony-stimulating factor-combined marrow-ablative chemotherapy and autologous blood cell transplantation for the treatment of patients with acute myelogenous leukemia in first remission. The Fukouka Bone Marrow Transplant Group.

1997 • 14 citations

Frequency of Clonal B Lymphocytes in Chronic Myelogenous Leukemia Evaluated by Fluorescence In Situ Hybridization

1998 • 12 citations

Production of human monoclonal antibodies against Epstein-Barr virus-specific antigens by the virus-immortalized lymphoblastoid cell lines

1986 • 9 citations

Treatment of acute non-lymphocytic leukemia with alternating non-cross resistant chemotherapy.

1988 • 7 citations